MICHIGAN TECHNOLOGICAL UNIVERSITY

NEW FOLLOW-ON CONTRACT EFFORT: THE WORK DIRECTIVES ISSUED HEREUNDER SHALL INVOLVE RESEARCH AND DEVELOPMENT EFFORTS ON VARIOUS ASPECTS RELATED TO SURVIVABILITY, ASSURED MOBILITY, AND MANEUVER SUPPORT MATERIAL SOLUTIONS.

TECHNICAL AND ENGINEERING SERVICES SUPPORT FOR ASSURED MOBILITY, SURVIVABILITY, AND MANEUVER SUPPORT MATERIAL SOLUTIONS FOR THE GROUND VEHICLE SYSTEMS CENTER GROUND VEHICLE SURVIVABILITY AND PROTECTION DIRECTORATE

ASSURED MOBILITY AND MANEUVER SUPPORT WORK DIRECTIVES.

IGF::OT::IGF

BIPARTISAN INFRASTRUCTURE LAW (BIL) SUPPLYING REFINED BATTERY MATERIALS INTO THE UNITED STATES ELECTRIC VEHICLE BATTERY SUPPLY CHAIN BY SYNERGIZING LITHIUM-ION BATTERY RECYCLING WITH MINE WASTE RECLAMATION. THE OBJECTIVE OF THIS PROJECT IS TO FURTHER DEVELOP, DEMONSTRATE, AND VALIDATE THE PROPOSED SYNERGIZED BATTERY RECYCLING AND METAL REFINING TECHNOLOGY THAT ENABLE AN EFFICIENT EXTRACTION AND RECOVERY OF BATTERY METALS FROM FLEXIBLE FEEDSTOCKS INCLUDING END-OF-LIFE LI-ION BATTERIES, SCRAPS FROM MANUFACTURING, AND ORE DERIVED FEEDSTOCK.

GRANT PROGRAM

MICHIGAN TECHNOLOGICAL UNIVERSITY: NEW AWARD. CONTROL NUMBER: 1564-1523 TITLE: ''NEXTCAR: CONNECTED AND AUTOMATED CONTROL FOR VEHICLE DYNAMICS AND POWERTRAIN OPERATION ON A LIGHT-DUTY MULTI-MODE HYBRID ELECTRIC VECHICLE''

200510!000827!5700!FA8750!AFRL/IFK !FA875005C0237 !A!N! !Y! ! !20050729!20070930!064184468!064184468!064184468!N!ALTARUM INSTITUTE !3520 GREEN CT, STE 300 !ANN ARBOR !MI!48105!03000!161!26!ANN ARBOR !WASHTENAW !MICHIGAN !+000000100407!N!N!000000649960!AD91!RDTE/OTHER DEFENSE-BASIC RESEARCH !A7 !ELECTRONICS AND COMMUNICATION EQUIP !000 !* !541710!E! !3! ! ! ! ! !20200930!B!A! !A! !A!N!U!2!002!E! !Z!Y!Z! ! !N!Z!N! ! ! ! ! !A!A!000!A!C!N! ! ! ! ! ! !0001! !

THE GOAL OF THE ADAPTIVE RADAR COUNTERMEASURES (ARC) PROGRAM IS TO DEVELOP THE CAPABILITY TO COUNTER ADAPTIVE RADAR THREATS IN TACTICALLY RELEVANT TIME FRAMES BASED ON OVER-THE-AIR OBSERVABLE SIGNALS. MTRI-MTU WILL BE PARTICIPATING IN TECHNICAL AREA 2.

COMPUTATIONALLY-DRIVEN NEXT GENERATION CARBON-CARBON COMPOSITE MATERIAL DEVELOPMENT

A COMMUNITY LABORATORY FACILITY FOR EXPLORING AND SENSING OF AEROSOL-CLOUD-DRIZZLE PROCESSES: THE AEROSOL-CLOUD-DRIZZLE CONVECTION CHAMBER

CYBERCORPS SCHOLARSHIP FOR SERVICE: CYBERSECURITY WORKFORCE PREPARATION

PROJECT TITLE ENABLING THE FUTURE OF GREAT LAKES BIOLOGICAL RESOURCE ASSESSMENTPROJECT PERIOD 9 1 2022 8 31 2023THE OVERARCHING GOAL OF THE PROPOSED USGS MTU MTRI COLLABORATION IS TO RESEARCH NEW AND EXPERIMENTAL BIOLOGICAL ASSESSMENT TOOLS THAT IMPROVE THE SPATIAL COVERAGE, ACCURACY, PRECISION, AND USEFULNESS OF USGS S GREAT LAKES SCIENCE PROGRAM THREE SPECIFIC TECHNOLOGICAL INNOVATIONS WILL BE INVESTIGATED TO ACHIEVE THIS GOAL UNDERWATER AND SURFACE AUTONOMY, UNDERWATER IMAGING, AND MACHINE LEARNING THESE INNOVATIONS COMBINED WILL GENERATE NEW KNOWLEDGE THAT IS USEFUL TO GREAT LAKES NATIONAL RESOURCE MANAGERS THESE INNOVATIONS WILL ENABLE USGS TO COLLECT AND PROCESS LAKE WIDE SURVEYS OF PREY FISH ABUNDANCES, ANSWERING DISCRETE RESEARCH QUESTIONS ABOUT THE FISH, LIMNOLOGY, AND ECOSYSTEMS MAP HABITATS AND DEVELOP MORE EFFICIENT TECHNOLOGICAL SOLUTIONS TO PERSISTENT SAMPLING PROBLEMS TO AID IN THE ACCOMPLISHMENT OF THIS GOAL, MICHIGAN TECH WILL WORK COLLABORATIVELY WITH USGS SCIENTISTS ON THE FOLLOWING ACTIVITIES ENGINEER, COORDINATE, AND DEPLOY ROBOTIC TECHNOLOGIES TO AUTONOMOUSLY COLLECT DATA ABOUT FISHERIES AND LAKE ECOSYSTEMS ASSIST WITH THE DELIVERY OF ANNUAL SURVEY RESULTS FOR BENTHIC FISHES FROM USGS S AUV IMAGERY DEVELOP AUTOMATED SOLUTIONS FOR INTERPRETATION AND PROCESSING OF BIOLOGICAL AND PHYSICAL FEATURES IN UNDERWATER IMAGERY, VIDEO, AND ACOUSTIC DATA ADVANCE TECHNIQUES FOR LARGE SCALE UNDERWATER MAPPING OF PHYSICAL HABITAT AND GEOMORPHOLOGY USING ACOUSTIC TECHNOLOGIES AUTOMATE THE INTERPRETATION OF SATELLITE AND AERIAL REMOTE SENSING DATA FOR PHYSICAL AND BIOLOGICAL FEATURES OF THE LAKE ENVIRONMENT DEVELOP COMPUTATIONAL TECHNOLOGIES, WORKFLOWS, AND SOFTWARE TO ACCELERATE DATA PROCESSING, ANALYSIS, AND DELIVERY TO PARTNERS ASSIST WITH PRODUCTION OF OPEN SOURCE TOOLS AND DATA THAT CAN BE EASILY ASSIMILATED BY THE PUBLIC AND USGS S PARTNERS THE DELIVERABLES AND OUTCOMES OF THIS PROJECT INCLUDE CUSTOM SOFTWARE FOR ROUND GOBY OBJECT IDENTIFICATION CUSTOM SOFTWARE FOR SUBMERGED AQUATIC VEGETATION PERCENT COVER ESTIMATION CUSTOM SOFTWARE FOR DREISSENID MUSSEL COVER AND COUNT PEER REVIEWED PUBLICATIONS ON RESEARCH RESULTS MULTIBEAM BATHYMETRY, BACKSCATTER, AND DERIVED PRODUCTS FOR GEOGRAPHIES OF INTEREST ANNOTATED IMAGE DATA SETS LABELLED FOR FISH, ALGAE, AND MUSSELS PUBLICLY RELEASED DATA SETS USED IN ANALYSES AND REPORTS ON RESEARCH OUTCOMES THE INTENDED BENEFICIARIES OF THIS WORK INCLUDE USGS STAKEHOLDERS, INCLUDING NATURAL RESOURCE AND LAND MANAGERS IN THE GREAT LAKES MICHIGAN TECHNOLOGICAL UNIVERSITY MTU AND MICHIGAN TECH RESEARCH INSTITUTE MTRI HAVE BEEN ASSISTING THE USGS IN THE PRIMARY RESPONSIBILITY OF ASSISTING NATURAL RESOURCE AND LAND MANAGERS BY PROVIDING THEM WITH SOUND BIOLOGICAL INFORMATION AND ASSISTANCE IN APPLYING THE INFORMATION TO THEIR NEEDS

U435CFM BAA (DARPA BAA) POWER LINE SENSOR MATURATION

TRACK&SUSPENSION TECHNICAL SUPPORT WORK DIRECTIVE CONTRACT

A LOW GREENHOUSE GAS (GHG) ADVANCED SPARK IGNITION (SI) ENGINE THAT CAN OPERATE ON NATURAL GAS (NG) AND NATURAL GAS-HYDROGEN (NG/H2) BLENDS WITH DIESEL-EQUIVALENT PERFORMANCE FOR OFF-ROAD APPLICATIONS. THE OBJECTIVE OF THIS TOPIC AREA IS TO DEVELOP AND DEMONSTRATE A COMMERCIALLY VIABLE NATURAL GAS ENGINE THAT CAN SIGNIFICANTLY REDUCE GHG EMISSIONS IN THE NON-ROAD SECTOR, INCLUDING OFF-ROAD, RAIL, AND/OR MARINE.

SCHOLARSHIPS FOR SUCCESS: HUSKY PATHWAYS FOR ACADEMIC WELLNESS AND SUCCESS -THIS PROJECT WILL CONTRIBUTE TO THE NATIONAL NEED FOR WELL-EDUCATED SCIENTISTS, MATHEMATICIANS, ENGINEERS, AND TECHNICIANS BY SUPPORTING THE RETENTION AND GRADUATION OF HIGH-ACHIEVING, LOW-INCOME STUDENTS WITH DEMONSTRATED FINANCIAL NEED AT MICHIGAN TECHNOLOGICAL UNIVERSITY. MICHIGAN TECH IS A SCIENCE, TECHNOLOGY, ENGINEERING, AND MATH-FOCUSED HIGH-RESEARCH ACTIVITY INSTITUTION WITH APPROXIMATELY 7000 STUDENTS, LOCATED IN THE RURAL UPPER PENINSULA OF MICHIGAN. OVER ITS SIX-YEAR DURATION, THIS PROJECT WILL FUND SCHOLARSHIPS TO 46 UNIQUE FULL-TIME STUDENTS WHO ARE PURSUING BACHELOR?S DEGREES AND ACCELERATED MASTER?S DEGREES IN APPLIED PHYSICS, ENGINEERING AND COMPUTER SCIENCE. FIRST-YEAR STUDENTS WILL RECEIVE FOUR-YEAR SCHOLARSHIPS; ADDITIONAL FINISHING SCHOLARSHIPS WILL BE AWARDED TO FOURTH-YEAR STUDENTS PURSUING AN ACCELERATED MASTER?S DEGREE. THIS PROJECT AIMS TO FOSTER PROFESSIONAL AND PERSONAL GROWTH IN SIX DISTINCT TYPES OF SOCIAL CAPITAL IDENTIFIED IN YOSSO?S CULTURAL WEALTH MODEL WHILE ALSO SUPPORTING METACOGNITION SKILLS AND SCHOLARS? SENSE OF BELONGING IN STEM. SPECIFIC PROJECT ACTIVITIES WILL INCLUDE A SUMMER BRIDGE OPPORTUNITY, A FIRST-YEAR EXPERIENCE DESIGNED TO DEVELOP SELF-AWARENESS, CONTINUAL CAREER COUNSELING AND ALUMNI MENTOR CONNECTIONS, AN OPTION FOR IMMERSIVE STUDY ABROAD, AND OPPORTUNITIES TO PERFORM UNDERGRADUATE RESEARCH. ULTIMATELY, THE COUPLING OF STUDENT FINANCIAL SUPPORT WITH SOCIAL CAPITAL RESOURCES WILL PREPARE TALENTED LOW-SOCIOECONOMIC STUDENTS TO ENTER THE WORKFORCE AS SUCCESSFUL WORLD-CLASS SCIENTISTS AND ENGINEERS. THE OVERALL GOAL OF THIS PROJECT IS TO INCREASE STEM DEGREE COMPLETION OF LOW-INCOME, HIGH-ACHIEVING UNDERGRADUATES WITH DEMONSTRATED FINANCIAL NEED. WITHIN ENGINEERING, COMPUTING, AND PHYSICS AT MICHIGAN TECH, 60% OF PELL STUDENTS SUCCESSFULLY GRADUATED WITHIN SIX YEARS, COMPARED TO 71% OF THE NON-PELL STUDENTS. THIS PROJECT WILL ELEVATE STUDENT?S CULTURAL ASSETS TO INCREASE THEIR SENSE OF BELONGING AND RETENTION TO ACHIEVE PELL STUDENTS? GRADUATION RATES COMPARABLE TO NON-PELL STUDENT LEVELS. USING AN ASSET-BASED APPROACH AND LEVERAGING EXISTING CURRICULA IN SELF-AUTHORSHIP THAT PLACES STUDENTS IN THE DRIVER?S SEAT TO IDENTIFY AND MAP THEIR OWN DEVELOPMENT PATHWAY, STUDENTS WILL STRATEGIZE WAYS TO DEVELOP THE SOCIAL CAPITAL ESSENTIAL TO NAVIGATING AND SUCCEEDING IN ACADEMIC SYSTEMS. PROGRAM ACTIVITIES WILL BE ASSESSED AND REFINED THROUGH PARTICIPATORY ACTION RESEARCH INVOLVING STEM SCHOLARS AS CO-RESEARCHERS, RECOGNIZING THEIR EXPERTISE IN THEIR OWN LIVED EXPERIENCES. EVALUATION WILL GUIDE PROGRAM REVISION SO THAT FUTURE PRACTICES WILL BE INFORMED BY STUDENT SCHOLARS. THIS PROJECT IS FUNDED BY NSF?S SCHOLARSHIPS IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS PROGRAM, WHICH SEEKS TO INCREASE THE NUMBER OF LOW-INCOME ACADEMICALLY TALENTED STUDENTS WITH DEMONSTRATED FINANCIAL NEED WHO EARN DEGREES IN STEM FIELDS. IT ALSO AIMS TO IMPROVE THE EDUCATION OF FUTURE STEM WORKERS AND TO GENERATE KNOWLEDGE ABOUT ACADEMIC SUCCESS, RETENTION, TRANSFER, GRADUATION, AND ACADEMIC/CAREER PATHWAYS OF LOW-INCOME STUDENTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

MICHIGAN TECHNOLOGICAL UNIVERSITY, NEW COMPETITIVE AGREEMENT, UNDER FOA NUMBER DE-FOA-0002707 (MINER) WITH CONTROL NUMBER 2707-1510 WITH PROJECT TITLE 'ENERGY REDUCTION AND IMPROVED CRITICAL MINERAL RECOVERY FROM LOW-GRADE DISSEMINATED SULPHIDE DEPOSITS AND MINE TAILINGS' WHICH WILL WORK WITH EXTRACTION OF ENERGY-RELEVANT MINERALS ECONOMICALLY AND ENVIRONMENTALLY-FRIENDLY FROM PRIMARY NICKEL AND COBALT RESOURCES IS ESSENTIAL FOR THE CLEAN TECH INDUSTRY, AS THE DEMAND FOR ENERGY-RELEVANT MINERALS IN THE CLEAN TECH SECTORS IS EXPECTED TO INCREASE BY 5X-10X IN THE NEXT 5-10 YEARS. THE OBJECTIVE OF THIS PROJECT IS TO ACHIEVE -10 WT% CO2 EQUIVALENT PER TONNE OF ORE PROCESSED COMPARED WITH EXISTING STATE-OF-THE-ART BY STORING CO2 WITH CO2-REACTIVE MINERALS AND RECOVERING 80% OF ENERGY-RELEVANT MINERALS FROM BOTH SULFIDE AND NICKEL-BEARING SILICATE MINERALS IN MINE TAILINGS. THE AIMS OF THIS PROJECT INCLUDE 1) ACHIEVING AND DEMONSTRATING 20 WT% CO2 STORAGE PER TONNE OF MINE TAILING WITHIN 4 HOURS WITH 10% ENERGY REDUCTION COMPARED TO THE STATE-OF-THE-ART, AND 2) ACHIEVING AND DEMONSTRATING A RECOVERY OF 50-80% YIELD OF NICKEL FROM MINE TAILING GENERATED WITH DOMESTIC LOW-GRADE DISSEMINATED SULFIDE ORES.

NEW AWARD TO MICHIGAN TECHNOLOGICAL UNIVERSITY. AWARD NUMBER: DE-EE0008800. PROJECT ENTITLED: PROPULSION SYSTEM HYBRIDIZATION AND ELECTRIFICATION AND ENERGY RECOVERY OF THE HYDRAULIC SYSTEM FOR A DIESEL POWERED OFF-ROAD CARRY/LIFT MACHINE.

FROM SORTED MSW TO CLEAN SYNGAS VIA SOLVENT TARGETED RECOVERY AND PRECIPITATION (STRAP)

IGF::OT::IGF - ELECTRONIC SUPPORT CRITICAL EXPERIMENT (ESCE)

THIS COOPERATIVE AGREEMENT IS AWARDED TO MICHIGAN TECHNOLOGICAL UNIVERSITY FOR A PROJECT ENTITLED, “CHEMICALLY AND BIOLOGICALLY CATALYZED PHYTOMINING OF NICKEL FROM SERPENTINE BARREN SOILS”. THIS AWARD IS BEING MADE IN ACCORDANCE WITH FOA NUMBER DE-FOA-0002784 (PHYTOMINES) AND CONTROL NUMBER 2784-1840.

MICHIGAN MASTER TEACHER FELLOWS PROGRAM

MULTI-DOMAIN INTELLIGENCE

SOLVENT TARGETED RECOVERY AND PRECIPITATION (STRAP) FOR RECOVERY OF BIOGENIC MATERIALS AND PLASTICS FROM MUNICIPAL SOLID WASTE (MSW)

TALENT SEARCH PROGRAM

CONTRIBUTION OF OREXIN SYSTEM TO HYPERTENSION - SUMMARY HYPERTENSION IS A MAJOR RISK FACTOR FOR CARDIOVASCULAR DISEASE, WITH SALT SENSITIVE HYPERTENSION (SSH) ACCOUNTING FOR 51% OF ALL CASES. AS AUGMENTED SYMPATHETIC NERVE ACTIVITY (SNA) AND DYSREGULATED NEUROENDOCRINE SECRETION ARE KNOWN TO PLAY CRITICAL ROLES IN THE DEVELOPMENT OF SSH, W E PROPOSE A STUDY TO INVESTIGATE THE MECHANISMS WHEREBY HYPERACTIVITY OF THE BRAIN OREXIN SYSTEM, MAY CRITICALLY INFLUENCE SNA AND NEUROENDOCRINE DYSREGULATION, THUS CONTRIBUTING TO SSH DEVELOPMENT. OREXIN A (OXA) IS A MULTIFUNCTIONAL NEUROPEPTIDE PRODUCED BY HYPOTHALAMIC NEURONS THAT PLAYS VARIOUS PHYSIOLOGICAL ROLES, INCLUDING CARDIOVASCULAR FUNCTION, THROUGH BINDING WITH ITS RECEPTORS. RECENT STUDIES SHOW THAT UPREGULATION OF BRAIN OREXIN SIGNALING OCCURS IN SEVERAL ANIMAL MODELS OF HYPERTENSION SUGGESTING IMPLICATIONS FOR OVERACTIVE BRAIN OREXIN SIGNALING IN HYPERTENSION DEVELOPMENT. HOWEVER, THE IMPACT OF OREXIN SYSTEM IN THE DEVELOPMENT OF SSH AND DETAILED MOLECULAR MECHANISMS UNDERLYING OREXIN SYSTEM MEDIATED HYPERTENSION DEVELOPMENT ARE POORLY UNDERSTOOD. OUR PRELIMINARY DATA SHOWS THAT A HIGH SALT (HS) DIET RESULTS IN HYPERTENSION, AND SIGNIFICANTLY INCREASES EXPRESSION OF OXA AND OREXIN 1 RECEPTOR (OX1R) IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS (PVN) OF DAHL SALT SENSITIVE (DAHL S) RATS, AN ANIMAL MODEL FOR HUMAN SSH, BUT NOT IN SALT RESISTANT RATS. INTERESTINGLY, HS DIET INTAKE IN DAHL S RATS ALSO INCREASES OX1R EXPRESSION IN ADRENAL GLANDS, A COMPONENT OF HYPOTHALAMIC-PITUITARY- ADRENAL (HPA) AXIS WHICH IS A CENTRAL NEUROENDOCRINE RESPONSE SYSTEM TO COMBAT STRESS AND REGULATE MULTIPLE PHYSIOLOGICAL FUNCTIONS. THE PVN CONTROLS SNA OUTFLOW AND NEUROENDOCRINE HORMONE, SUCH AS VASOPRESSIN (AVP) AND CORTICOTROPIN-RELEASING HORMONE (CRH), PRODUCTION. CENTRAL ADMINISTRATION OF OXA INCREASES SNA OUTFLOW AND PVN AVP EXPRESSION AS WELL AS PLASMA CORTICOSTERONE LEVELS, A HALLMARK OF HPA AXIS ACTIVATION. HYPERACTIVITY OF HPA AXIS IS INVOLVED IN MULTIPLE DISEASES INCLUDING HYPERTENSION. LESIONS IN THE PVN PREVENT HIGH SALT INDUCED HYPERTENSION IN DAHL S RATS. THIS BODY OF EVIDENCE SUGGESTS THAT PVN OX1R ACTIVATION IS INVOLVED IN SNA AND HPA AXIS REGULATION, AND INCREASED PVN OXA-OX1R SIGNALING INDUCED BY HIGH SALT INTAKE MAY STIMULATE NEUROENDOCRINE SYSTEMIC SECRETION, TRIGGER LONG-TERM ADAPTIVE CHANGES THROUGH REGULATING DOWNSTREAM GENE EXPRESSION, PRODUCING EXCESSIVE EXCITATORY NEUROCHEMICALS, RESULTING IN AUGMENTED PVN SYMPATHETIC TONE, AND LEADING TO SSH. THE OBJECTIVES OF THIS PROJECT ARE: (I) INVESTIGATE WHETHER CHRONIC KNOCKDOWN OF PVN OX1R EXPRESSION DECREASES PLASMA CORTICOSTERONE LEVELS, ATTENUATE HS INDUCED INCREASE IN SNA, AND PREVENT SSH; (II) ELUCIDATE THE MOLECULAR MECHANISM UNDERLYING THE RELATIONSHIP BETWEEN OXA-OX1R AND ITS AUGMENTATION OF SNA AND DYSREGULATION OF HPA AXIS. A COMBINATION OF IN VIVO GENE TRANSDUCTION, ELECTROPHYSIOLOGICAL RECORDINGS, AND MOLECULAR AND BIOCHEMICAL APPROACHES WILL BE EMPLOYED TO ANSWER OUR QUESTIONS USING SALT SENSITIVE AND NORMOTENSIVE RAT MODELS. OUR STUDIES MAY IDENTIFY NEW TARGETS FOR THERAPEUTIC INTERVENTION IN HYPERTENSION.

INFORMING HUMAN RISK PERCEPTION OF AND RESPONSE TO WILDLAND FIRE SMOKE USING NEW SATELLITE DERIVED EXTREME SMOKE EVENT DATA

INTEGRATED AND CONTINUOUS MANUFACTURING OF AN INFLUENZA VACCINE - PROJECT SUMMARY INFLUENZA A AFFECTS 5-30% OF THE WORLD’S POPULATION ANNUALLY, RESULTING IN 3 TO 5 MILLION CASES OF SERIOUS ILLNESS AND 250,000 TO 500,000 DEATHS EACH YEAR. VACCINATION IS THE BEST WAY TO PREVENT DISEASE. >80% OF THE INFLUENZA VACCINES ARE MADE IN EGGS, AND THIS MAKES THE PROCESS SLOW AND NOT ABLE TO QUICKLY CHANGE AS THE INFLUENZA VIRUS MUTATES. THE VACCINE IS OPTIMIZED TO GROW IN EGGS, WHICH MAKES IT A LESS LIKE THE CIRCULATING VIRUS, AND THUS REDUCES THE EFFECTIVENESS OF THE VACCINE. ONE WAY TO IMPROVE THE VACCINE IS TO USE CELL-BASED VACCINES. HOWEVER, CELLS-BASED VACCINES ARE EXPENSIVE TO PRODUCE AND THE MANUFACTURING FACILITIES ARE EXPENSIVE. AFTER 10 YEARS ON THE MARKET, CELL-BASED VACCINES ARE NOT THE DOMINATE VACCINE USED IN THE US. WE PROPOSE TO DEVELOP A NOVEL MANUFACTURING PROCESS OF A CELL-BASED INFLUENZA VIRUS LIKE PARTICLE (VLP). THE PROCESS WILL CONTINUOUSLY PRODUCE THE VLP, WHICH WILL ALLOW FOR SMALLER EQUIPMENT AND THUS REDUCE THE COST OF BUILDING A NEW MANUFACTURING PLANT. CONTINUOUS PROCESSING ALSO REDUCES OPERATING COSTS, ALLOWING FOR THE VACCINE TO BE SOLD AT A LOWER COST AND LIKELY COMPETING IN PRICE WITH EGG-PRODUCED VACCINES. THE VLP WILL ELICIT A STRONGER IMMUNE RESPONSE THAN EGG-BASED VACCINES AND THE MODULAR DESIGN WILL ALLOW FOR QUICK ADAPTION OF THE VACCINE TO THE CIRCULATING INFLUENZA STRAINS. OUR TEAM HAS DESIGNED A NOVEL, END TO END, CONTINUOUS PROCESS TO MANUFACTURE AN INFLUENZA VLP. FIRST, WE WILL CONTINUOUS PRODUCE THE VLP IN A UNIQUE, THREE-REACTOR BIOREACTOR CASCADE THAT WILL ALLOW FOR CONTINUOUS PROCESSING USING A BACULOVIRUS PRODUCTION SYSTEM IN SF9 INSECT CELLS. THERE IS NOT CURRENTLY A CONTINUOUS BACULOVIRUS PRODUCTION SYSTEM IN USE. THE CONTINUOUS DOWNSTREAM WILL USE AQUEOUS TWO-PHASE EXTRACTION AND OTHER POLISHING STEPS TO PURIFY THE VLP. CHROMATOGRAPHY AND OTHER PERIODIC OPERATIONS WILL BE AVOIDED. THE VLP WILL PRODUCE HA PROTEIN ANTIGENICALLY IDENTICAL TO THE CHOSEN CIRCULATING STRAIN WITH NO POTENTIAL FOR SELECTION OF HA MUTATIONS AND THE HA PROTEIN CAN EASILY BE CHANGED TO ANOTHER CIRCULATING INFLUENZA STRAIN, AS NEEDED. PROCESS ANALYTICS WILL BE CONDUCTED TO CONFIRM THE PURITY AND ANTIGENICITY OF THE PRODUCED INFLUENZA VLP. AT THE COMPLETION OF THIS PROJECT, THE TEAM WILL RUN THE FIRST END TO END CONTINUOUS PROCESS FOR ONE MONTH TO PRODUCE AN INFLUENZA VLP AND THE PROCESS ECONOMICS WILL BE EVALUATED TO DETERMINE THE ECONOMIC FEASIBILITY OF THE PROCESS. THE VLP WILL HAVE SUPERIOR IMMUNOGENICITY TO EGG-DERIVED VACCINES AND SUBUNIT VACCINES. THIS WILL BE THE FIRST EVER DEMONSTRATION OF A TRULY END-TO-END CONTINUOUS VLP PRODUCTION PROCESS THAT WILL REVOLUTIONIZE BIOLOGICS MANUFACTURING FOR MULTIPLE PRODUCTS, INCLUDING OTHER VACCINES AND GENE THERAPY VECTORS.

IGF::OT::IGF RESEARCH IAW SOW ENTITLED SSPARC MIMO TOWER OF BABEL

NRT-HDR: INTEGRATIVE TRAINING IN DATA SCIENCE-ENABLED SENSING OF THE ENVIRONMENT FOR CLIMATE ADAPTATION (DATASENSE) -CLIMATE CHANGE IS ONE OF THE MOST COMPLEX ISSUES FACING HUMANKIND TODAY, AND IT IS HAVING PROFOUND IMPACTS ON THE ENVIRONMENT AND THE QUALITY OF LAND, WATER, AND AIR WE ALL DEPEND ON. DEVELOPMENT OF NEW SENSOR TECHNOLOGIES, GROWTH IN THE AMOUNT AND AVAILABILITY OF SENSOR DATA, ADVANCES IN COMPUTATIONAL METHODS, AND EXPANSION OF COMPUTATIONAL POWER WILL ENABLE NEW APPROACHES TO BETTER UNDERSTAND CHANGES TO THE ENVIRONMENT. THESE EMERGING TECHNOLOGIES AND TOOLS CAN CONTRIBUTE TO SOLUTIONS FOR MULTIPLE CHALLENGING ENVIRONMENTAL PROBLEMS. HOWEVER, TO REALIZE THIS POTENTIAL, THERE IS AN URGENT NEED TO EQUIP NEXT-GENERATION SCIENTISTS AND ENGINEERS WITH THE ABILITY TO UNDERSTAND AND APPLY DATA SCIENCE ACROSS DIVERSE FIELDS AND IN CULTURALLY RESPONSIVE AND EQUITY MINDED WAYS. THIS NATIONAL SCIENCE FOUNDATION RESEARCH TRAINEESHIP (NRT) AWARD TO MICHIGAN TECHNOLOGICAL UNIVERSITY WILL ADDRESS THIS NEED BY TRAINING PHD STUDENTS IN DATA-SCIENCE-ENABLED SENSING OF THE ENVIRONMENT. THE PROJECT WILL PREPARE 28 PHD STUDENTS, INCLUDING 15 FUNDED TRAINEES, FROM MULTIPLE DISCIPLINES INCLUDING COMPUTATIONAL AND DATA SCIENCES, FORESTRY, GEOLOGICAL ENGINEERING, AND ENVIRONMENTAL ENGINEERING. THE INTEGRATIVE RESEARCH AND TRAINING EXPERIENCES ARE FRAMED AROUND THE DATA SCIENCE LIFECYCLE AND THREE KNOWLEDGE PILLARS: SENSORS AND SENSING TECHNOLOGIES, COMPUTATIONAL ANALYSIS, AND APPLICATION DOMAIN KNOWLEDGE. ALONG WITH THE KNOWLEDGE GENERATION IN SCIENTIFIC RESEARCH, THE DATA SCIENCE LIFECYCLE ALSO CALLS FOR THE PROFESSIONAL DEVELOPMENT AND CUTTING-EDGE SKILLS AND COMPETENCIES, REQUIRED BY INDUSTRY, GOVERNMENT, AND ACADEMIC EMPLOYERS OF THESE GRADUATES. THE GOAL OF THIS PROJECT IS TO PROVIDE INTEGRATIVE, CULTURALLY-RESPONSIVE, AND EQUITY MINDED TRAINING, RESEARCH, AND MENTORING EXPERIENCES FOR GRADUATE STUDENTS THAT PRODUCE COMB-SHAPED PROFESSIONALS TO ADDRESS THESE COMPLEX, CLIMATE-ADAPTATION-RELATED PROBLEMS. INTEGRATED TRAINING ELEMENTS INCLUDE: INTERDISCIPLINARY CURRICULA (COURSE AND GRADUATE CERTIFICATE), INTERDISCIPLINARY RESEARCH, SUMMER EXPERIENCES, RESEARCH SEMINARS, RESEARCH SYMPOSIA, CAREER DEVELOPMENT TRAINING, OUTREACH, AND NEAR-PEER MENTORING. TRAINEES WILL HAVE OPPORTUNITIES FOR LEADERSHIP POSITIONS IN ORGANIZING ASPECTS OF THE TRAINING ACTIVITIES; ADVANCING PROFESSIONAL SKILLS IN SCIENTIFIC COMMUNICATION (READING, WRITING, AND PRESENTATIONS); AND CAREER DEVELOPMENT TRAINING TO GROW SKILLS IN LEADERSHIP, NEGOTIATION, TEAM BUILDING, NETWORKING AND PROJECT MANAGEMENT. THE PROJECT WILL CREATE A NEW GRADUATE CERTIFICATE IN DATA SCIENCE-ENABLED ENVIRONMENTAL REMOTE SENSING. SUCCESSFUL AND EFFECTIVE TRAINING ELEMENTS WILL BE DISSEMINATED AS BEST PRACTICES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

PARTNERING TO PREPARE STEM MASTER TEACHERS FOR MICHIGAN?S MIDDLE SCHOOLS -THE PROJECT AIMS TO SERVE THE NATIONAL NEED OF DEVELOPING AND RETAINING HIGHLY EFFECTIVE STEM MASTER TEACHERS. THE PROJECT INVOLVES A STEM-DOMINANT TECHNOLOGICAL UNIVERSITY, A PRIMARILY UNDERGRADUATE INSTITUTION KNOWN FOR EXPERTISE IN TEACHER EDUCATION, AND HIGH-NEED SCHOOL DISTRICTS IN MICHIGAN. THROUGH THIS COLLABORATION THE PROJECT WILL RECRUIT, TRAIN, AND RETAIN HIGH-QUALITY STEM TEACHER LEADERS THAT CAN SERVE AS EFFECTIVE MENTORS AND ADDRESS A SYSTEMIC SHORTAGE OF SCIENCE TEACHERS. DUE TO CHRONIC UNDERSTAFFING AND LOW RETENTION RATES, INCREASING PROPORTIONS OF STEM TEACHERS ARE INEXPERIENCED AND/OR UNDERPREPARED; A PROBLEM THAT MOST AFFECTS HIGH-NEED SCHOOL DISTRICTS. THIS PROBLEM IS IMPORTANT BECAUSE STUDENTS' LEARNING IS NEGATIVELY IMPACTED WHEN EFFECTIVE TEACHERS ARE NOT AVAILABLE. THIS PROJECT PROVIDES A PROVEN, EFFECTIVE PATHWAY TO TRAIN PRACTICING TEACHERS TO SERVE AS EFFECTIVE MENTORS AND LEADERS IN THEIR SCHOOLS THROUGH COLLABORATION WITH OTHER TEACHER LEADERS AROUND THE STATE. THE EXPECTED OUTCOMES OF THIS PROJECT ARE: DEVELOPMENT OF 30 PRACTICING SCIENCE TEACHER LEADERS IN DIVERSE, HIGH-NEED SCHOOLS IN GRADES 5-9; AND DEVELOPMENT OF AN ONLINE MASTER'S DEGREE DESIGNED FOR STEM TEACHERS OFFERED BY TWO PARTNERING UNIVERSITIES. THE ROLE OF TEACHER LEADERS IS CRITICAL FOR IMPROVING THE PERFORMANCE OF STUDENTS IN STEM COURSES AND INCREASING STUDENTS? INTEREST IN PURSUING FUTURE STEM COURSES AND CAREERS. THIS PROJECT AT MICHIGAN TECHNOLOGICAL UNIVERSITY INCLUDES PARTNERSHIPS WITH NORTHERN MICHIGAN UNIVERSITY, COPPER COUNTRY INTERMEDIATE SCHOOL DISTRICT, KALAMAZOO PUBLIC SCHOOLS, KENTWOOD PUBLIC SCHOOLS, MARQUETTE-ALGER REGIONAL EDUCATION SERVICE AGENCY, MENOMINEE COUNTY INTERMEDIATE SCHOOL DISTRICT, MIDLAND PUBLIC SCHOOLS, AND THE UPPER PENINSULA CENTER FOR EDUCATIONAL DEVELOPMENT. PROJECT GOALS INCLUDE THE RECRUITMENT AND PREPARATION OF 30 NEW STEM TEACHER LEADERS OVER SIX YEARS FOR SERVICE IN GRADES 5-9 IN DIVERSE, HIGH-NEED SCHOOLS WITHIN MICHIGAN, AND PROVIDE AN ACCESSIBLE TRACK TO EARN THEIR MASTER'S DEGREE. DESPITE A NEED FOR TEACHER LEADERS, MOST HIGH-NEED SCHOOLS LACK THE RESOURCES NEEDED TO TRANSFORM PRACTICING TEACHERS INTO TEACHER LEADERS. THIS PROJECT ADDRESSES THAT NEED BY PREPARING TEACHER LEADERS TO EMPLOY EVIDENCE-BASED METHODS TO CONTINUALLY ENHANCE THEIR OWN EFFECTIVENESS AND HELP LESS EXPERIENCED AND NOVICE TEACHERS DO THE SAME. TEACHERS WILL RECEIVE THE TRAINING NECESSARY TO DELIVER LONG-TERM BENEFITS TO THEIR SCHOOLS BY PROVIDING MENTORING AND PROFESSIONAL LEARNING TO THEIR COLLEAGUES. THIS PROJECT INTENDS TO ULTIMATELY IMPROVE THE PERFORMANCE OF STUDENTS IN STEM COURSES, INCREASE STUDENTS' INTEREST IN PURSUING FUTURE STEM COURSES AND CAREERS, AND SERVE AS A MODEL FOR PARTNERING EFFORTS IN OTHER STATES. WESTERN MICHIGAN UNIVERSITY WILL PERFORM EXTERNAL EVALUATION. THE EVALUATORS WILL COLLECT AND REVIEW QUANTITATIVE AND QUALITATIVE DATA RELATED TO PROGRAM IMPLEMENTATION AND THE EFFECT OF PROJECT PROGRAMMING ON INSTRUCTIONAL PRACTICES AND LEADERSHIP SKILLS. PROJECT FINDINGS AND MATERIALS WILL BE DISSEMINATED THROUGH PUBLICATIONS, PRESENTATIONS, AND WORKSHOPS. THIS TRACK 3: MASTER TEACHING FELLOWSHIPS PROJECT IS SUPPORTED THROUGH THE ROBERT NOYCE TEACHER SCHOLARSHIP PROGRAM (NOYCE). THE NOYCE PROGRAM SUPPORTS TALENTED STEM UNDERGRADUATE MAJORS AND PROFESSIONALS TO BECOME EFFECTIVE K-12 STEM TEACHERS AND EXPERIENCED, EXEMPLARY K-12 TEACHERS TO BECOME STEM MASTER TEACHERS IN HIGH-NEED SCHOOL DISTRICTS. IT ALSO SUPPORTS RESEARCH ON THE EFFECTIVENESS AND RETENTION OF K-12 STEM TEACHERS IN HIGH-NEED SCHOOL DISTRICTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

RESEARCH AND DEVELOPMENT COST

PERSONALIZED MANAGEMENT OF INTRACRANIAL ANEURYSMS USING COMPUTER-AIDED ANALYTICS - ABSTRACT THE PRIMARY OBJECTIVE IS TO DEVELOP AN ARTIFICIAL INTELLIGENCE-CENTRIC, QUANTITATIVE AND NONINVASIVE SOFTWARE PLATFORM THAT CAN BE INTEGRATED INTO 3D ANGIOGRAPHIC SCANNERS (DSA, CTA OR MRA) TO PROVIDE GUIDANCE REGARDING THE DIAGNOSIS AND MANAGEMENT OF INTRACRANIAL ANEURYSMS (IA). HEMORRHAGIC STROKE SECONDARY TO RUPTURED IAS LEADS TO SIGNIFICANT MORBIDITY AND MORTALITY AND AFFECTS OVER 35,000 PATIENTS ON A YEARLY BASIS IN THE UNITED STATES. THE DIAGNOSIS OF ASYMPTOMATIC IAS IS ON THE RISE WITH THE INCREASING USE OF CEREBRAL IMAGING. HOWEVER, GUIDANCE REGARDING WHICH ANEURYSMS SHOULD BE TREATED HAS NOT ADVANCED. LEVERAGING RECENT ADVANCES IN COMPUTATIONAL SCIENCE AND TECHNOLOGY, PARTICULARLY ARTIFICIAL INTELLIGENCE, THE PROPOSED SOFTWARE PLATFORM BUILT ON TWO ENABLING TECHNOLOGIES CAN (1) PROPEL AUTOMATED “PATIENT-SPECIFIC” HEMODYNAMIC EVALUATIONS INTO THE CLINICAL WORKFLOW AND (2) CONDUCT “DATA-DRIVEN” RISK ASSESSMENTS OF IA RUPTURE ON AN INDIVIDUAL BASIS. SPECIFIC RESEARCH AIMS ARE TO (1) DEVELOP A CLINICALLY-ORIENTED CFD PLATFORM THAT ENABLES AUTOMATED “PATIENT-SPECIFIC” HEMODYNAMIC EVALUATIONS OF IAS, (2) INVESTIGATE DATA-DRIVEN ANALYTICS TOWARD PREDICTION OF RUPTURE RISK FOR IAS AND (3) EVALUATE THE DATA-DRIVEN ANALYTICS IN A BLIND STUDY. ONCE VALIDATED, A FOLLOW-UP R01 PROJECT IS PLANNED TO EXAMINE THE CLINICAL UTILITY OF THE PROPOSED SOFTWARE PLATFORM IN A PROSPECTIVE CLINICAL STUDY AS A SINGLE GATEWAY FOR COMPUTER-AIDED EVALUATION OF CEREBRAL ANEURYSMS.

RESEARCH AND DEVELOPMENT COST

PURPOSE: WHILE ACIDIFICATION OF THE OCEANS DUE TO INCREASED ATMOSPHERIC CO2 IS A WELL-KNOWN PHENOMENON, IT REMAINS AN OPEN QUESTION AS TO WHETHER A SIMILAR ACIDIFICATION IS OR WILL HAPPEN IN THE LAURENTIAN GREAT LAKES OR OTHER LARGE LAKES OF THE WORLD. EXISTING MEASUREMENTS SHOW NO EVIDENCE OF ACIDIFICATION OVER THE PAST 30-40 YEARS, BUT THE DATA ARE SPARSE, OF POOR QUALITY, AND INADEQUATE TO PROVE WHETHER OR NOT ACIDIFICATION IS HAPPENING OR WILL IN THE FUTURE. THIS PROJECT WILL DEMONSTRATE HOW A HIGH-QUALITY SET OF DATA CAN BE COLLECTED AND MODELLED TO DETERMINE WHAT FACTORS ARE REGULATING PH ON A DAILY SCALE. INSTRUMENTED MOORINGS WILL BE INSTALLED IN LAKES SUPERIOR AND ERIE IN CENTRAL LOCATIONS TO AVOID INFLUENCE OF CATCHMENT INPUTS. ATMOSPHERIC AND DISSOLVED CO2 AND PH WILL BE MEASURED BY HIGH PRECISION INSTRUMENTS FOR TWO YEARS. ANCILLARY CHEMICAL AND BIOLOGICAL PROCESS DATA WILL BE COLLECTED TO GAIN A FULLER UNDERSTANDING OF FACTORS AFFECTING PH. A COUPLED HYDRODYNAMIC-BIOGEOCHEMICAL MODEL WILL BE IMPLEMENTED AND VALIDATED WITH THE MEASURED DATA. MODEL EXPERIMENTS AND STATISTICAL ANALYSIS OF THE MEASUREMENT DATA WILL BE USED TO DETERMINE WHETHER TEMPERATURE CHANGE, VERTICAL MIXING OF THE WATER COLUMN, BIOLOGICAL PROCESSES, AIR-WATER EXCHANGE, OR CHANGES IN POOLS OF DISSOLVED ORGANIC AND INORGANIC CARBON ARE MORE IMPORTANT IN CONTROLLING PH. THE NOAA GREAT LAKE ENVIRONMENTAL RESEARCH LAB (GLERL) WILL PARTNER WITH MICHIGAN TECHNOLOGICAL UNIVERSITY ON THIS PROJECT. EXPERIENCE FROM THIS PROJECT WILL ENABLE GLERL TO IMPLEMENT SIMILAR STUDIES IN THE OTHER GREAT LAKES AS WELL AS HOW TO DEVELOP MODELS TO PREDICT LAKE PH UNDER AN ALTERED CLIMATE.

OLIGODEOXYNUCLEOTIDE SYNTHESIS USING PROTECTING GROUPS AND A LINKER CLEAVABLE UND

UPWARD BOUND PROGRAM

DDARPA TRIAGE CHALLENGE (DTC) UNDER THE SIGNATURES OF TRAUMA FOR ALGORITHM-ASSISTED CLINICAL ASSESSMENT, TRIAGE, AND OBSERVATION (STACATO) PROGRAM

PURPOSE: THE PURPOSE OF THIS COOPERATIVE AGREEMENT TO PROVIDE UNDERGRADUATE/GRADUATE RESEARCHERS, INDIVIDUALS WITH BACHELORS OR MASTER'S DEGREES, POST-DOCTORAL ASSOCIATES, SENIOR RESEARCH FELLOWS AND ACADEMIC AFFILIATES WITH FELLOWSHIP OPPORTUNITIES AND FINANCIAL ASSISTANCE TO OBTAIN LABORATORY EXPERIENCES AND AID IN DEVELOPING COLLABORATIVE RESEARCH RELATIONSHIPS WITH NIST STAFF WITHIN THE NIST BOULDER LABORATORY.ACTIVITIES TO BE PERFORMED: PREP SEEKS TO ENCOURAGE THE GROWTH AND PROGRESS OF SCIENCE AND ENGINEERING IN THE UNITED STATES, INCLUDING THE ENCOURAGEMENT OF WOMEN AND MINORITY RESEARCHERS SEEKING TO FURTHER THEIR PROFESSIONAL DEVELOPMENT, AND TO NURTURE RESEARCHERS AND POST-DOCTORAL ASSOCIATES CONSIDERED TO BE POTENTIAL FUTURE NIST EMPLOYEES.EXPECTED OUTCOMES: THE OBJECTIVES OF THE PREP PROGRAM ARE TO: 1) ENCOURAGE THE GROWTH AND PROGRESS OF SCIENCE AND ENGINEERING IN THE UNITED STATES BY PROVIDING RESEARCH OPPORTUNITIES FOR PREP RESEARCHERS WITH NIST SCIENTISTS AND ENGINEERS AND EXPOSING THEM TO CUTTING-EDGE RESEARCH AND DEVELOPMENT (R&D); 2) PROMOTE THE PURSUIT OF DEGREES OR PROFESSIONAL DEVELOPMENT, AS APPLICABLE, FOR PREP RESEARCHERS; AND 3) PROMOTE DIVERSITY AND EQUITY IN STEM.INTENDED BENEFICIARIES: NIST AND NIST RESEARCHERS, AND UNDERGRADUATE/GRADUATE RESEARCHERS, INDIVIDUALS WITH BACHELORS OR MASTER'S DEGREES, POST-DOCTORAL ASSOCIATES, SENIOR RESEARCH FELLOWS AND ACADEMIC AFFILIATES, EMPLOYED BY OR AFFILIATED WITH THE UNIVERSITIES.SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

CAREER: CAN MATERIAL COSTS CONTRIBUTE TO THE STRUCTURING OF BIODIVERSITY PATTERNS FROM GENOMES AND TRANSCRIPTOMES TO MULTISPECIES COMMUNITIES?

CONCEIVED AS A SIMPLY PRESENTED INSPIRATION FOR PEOPLE WITH AN INTEREST IN ASTRONOMY AND RELATED TOPICS THE ASTRONOMY PICTURE OF THE DAY (APOD) HAS BECOME A SUCCESSFUL PROJECT THAT RETAINS ITS PREMISE OF ELEGANT SIMPLICITY AND ACCESSIBILITY WHILE SERVING A WIDE RANGE OF AUDIENCES ACROSS THE U.S. AND BEYOND. EACH DAY APOD SHOWCASES A SINGLE IMAGE CAPTURED BY A NASA MISSION SUBMITTED BY AN ENTHUSIASTIC CONTRIBUTOR OR OTHERWISE MADE AVAILABLE. USING THE IMAGE AS A HOOK APOD THEN OFFERS AN INSIGHTFUL AND EDUCATIONAL DESCRIPTION WITH HYPERLINKED TEXT WRITTEN BY ONE OF ITS TWO PROFESSIONAL ASTRONOMER CURATORS. APOD'S DIVERSE AND EDUCATIONALLY ORIENTED LINKS ENCOURAGE INQUISITIVE READERS TO EXPLORE OTHER SITES FREQUENTLY NASA AND SMD SITES THAT CONTAIN A WIDE RANGE OF RELATED NASA AND SCIENCE-ORIENTED INFORMATION. THIS PRIMARY PURPOSE OF THIS PROPOSAL IS TO CONTINUE SUPPORT FOR THE ALREADY SUCCESSFUL APOD WEBSITE.

WOU-MMA: RESEARCH & DEVELOPMENT FOR THE SOUTHERN WIDE-FIELD GAMMA-RAY OBSERVATORY (SWGO) -EARTHBOUND OBSERVATORIES COLLECT DATA TO INVESTIGATE SOME OF THE MOST CHALLENGING AND FUNDAMENTAL QUESTIONS IN PHYSICS AND ASTRONOMY TODAY. THEY IDENTIFY COSMIC PARTICLE ACCELERATORS, STUDY THE INTERSTELLAR MEDIUM, SEARCH FOR SIGNS OF DARK MATTER IN DISTANT GALAXIES, AND TEST THE LIMITS OF EINSTEIN'S THEORY OF SPECIAL RELATIVITY. WIDE FIELD-OF-VIEW, HIGH-DUTY-CYCLE INSTRUMENTS LIKE THE NSF-FUNDED HIGH-ALTITUDE WATER CHERENKOV (HAWC) OBSERVATORY IN MEXICO AND THE LARGE HIGH-ALTITUDE AIR SHOWER OBSERVATORY (LHAASO) IN CHINA HAVE RECENTLY HAD TREMENDOUS SUCCESSES IN SURVEYING THE SKY FOR GAMMA-RAYS - HIGH ENERGY RAYS OF LIGHT BEYOND THE VISIBLE SPECTRUM. THEIR OBSERVATIONS HAVE LED TO DISCOVERIES IN ALL THE AREAS JUST MENTIONED. THESE BREAKTHROUGHS UNDERSCORE THE CRUCIAL ROLE THAT GROUND-BASED FACILITIES PLAY IN PHYSICS AND ASTRONOMY. THIS PROJECT GATHERS SCIENTISTS FROM EIGHT US INSTITUTIONS TO PERFORM RESEARCH AND DEVELOPMENT (R&D) FOR A NEXT-GENERATION GROUND-BASED SURVEY INSTRUMENT FOR ASTROPHYSICS RESEARCH: THE SOUTHERN WIDE-FIELD GAMMA-RAY OBSERVATORY (SWGO). THE SWGO WILL BE LOCATED IN THE SOUTHERN HEMISPHERE, WHERE IT WILL HAVE AN UNPRECEDENTED WIDE-FIELD VIEW OF THE CENTER REGION OF OUR GALAXY FOR GAMMA RAYS. THE U.S. INSTITUTIONS ARE PART OF A GLOBAL COLLABORATION INVOLVING MORE THAN 70 INSTITUTIONS IN 14 COUNTRIES THAT ARE WORKING TO MAKE THE SWGO A REALITY. THE PROJECT WILL ENSURE U.S. LEADERSHIP IN THIS FIELD OF GROUND-BASED ASTROPHYSICS. THE PROJECT TEAM IS COMMITTED TO INCREASING INCLUSIVE EXCELLENCE IN PHYSICS AND ASTRONOMY AND WILL LEVERAGE THE FACT THAT THE SWGO WILL BE BUILT IN A SPANISH SPEAKING COUNTRY IN SOUTH AMERICA, TO ENHANCE OUTREACH TO HISPANIC COMMUNITIES IN THE U.S. THE SWGO WILL ALMOST CONTINUOUSLY SURVEY THE GAMMA-RAY SKY IN THE SPACE AND TIME DOMAIN AND PROVIDE SYNERGIES WITH OBSERVATORIES LIKE THE ICECUBE NEUTRINO OBSERVATORY, THE LASER INTERFEROMETER GRAVITATIONAL-WAVE OBSERVATORY (LIGO), THE VIRGO INTERFEROMETER, THE FERMI SPACE TELESCOPE AND THE CHERENKOV TELESCOPE ARRAY (CTA). THE FACILITY WILL PROVIDE DAILY UNBIASED MONITORING FOR VARIABLE SOURCES AND NEAR-REAL-TIME ALERTS TO OTHER INSTRUMENTS. ITS ARCHIVAL DATA SET WILL ENABLE REGIONS OF THE SKY TO BE STUDIED BOTH BEFORE AND AFTER ALERTS FROM OTHER EXPERIMENTS ARE REPORTED. EXCELLENT SENSITIVITY TO THE MOST POWERFUL PARTICLE ACCELERATORS IN THE LOCAL GALACTIC NEIGHBORHOOD IS ONE OF THE GREATEST STRENGTHS OF SWGO AND WILL ENABLE AN UNPRECEDENTED STUDY OF PEVATRONS TOWARD THE GALACTIC CENTER REGION. TO ACHIEVE THIS, THE OPTIMAL OBSERVATORY SITE AND DETECTOR DESIGN NEED TO BE IDENTIFIED. SUPPORTED BY THIS SWGO R&D AWARD THE TEAM WILL INVESTIGATE SOUTHERN HEMISPHERE SITES AND PERFORM END-TO-END PROTOTYPE TESTS OF WATER CHERENKOV DETECTORS INCLUDING ELECTRONICS AND DAQ SYSTEMS AT THE EXISTING HAWC OBSERVATORY AND THE ULTIMATELY SELECTED SWGO SITE. THE PRODUCTION OF HIGH-LEVEL SIMULATION OUTPUTS THAT ARE INFORMED BY REALISTIC BENCHMARK TESTS WILL ALLOW OPTIMIZATION OF THE SCIENCE OUTPUT OF THE FUTURE SWGO. THE AWARD IS ALIGNED WITH THE NSF BIG IDEA OF WINDOWS ON THE UNIVERSE: THE ERA OF MULTI-MESSENGER ASTROPHYSICS AS IT COORDINATES THE USE OF MULTI-MESSENGER OBSERVATIONS OF VERY HIGH ENERGY GAMMA RAYS USING A WIDE-FIELD DETECTION APPROACH. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

CIF: MAKING THE PI CONVECTION-CLOUD CHAMBER AVAILABLE TO THE COMMUNITY FOR AEROSOL-CLOUD-TURBULENCE RESEARCH

THE OVERARCHING GOAL OF THIS PROJECT IS TO IMPROVE NASA S ABILITY TO MODEL AND RESPOND TO THE NEXT MAJOR VOLCANIC ERUPTION.

IGF::OT::IGF EXPERIMENTS, SCENARIOS, CONOPS&PROTOTYPE ENGINEERING (ESCAPE)

RONALD E. MCNAIR POSTBACCALAUREATE ACHIEVEMENT PROGRAM

SUDOKU

CONTROL NO. 2784-1653 MICHIGAN TECHNOLOGICAL UNIVERSITY NEW AWARD UNDER E.T. TOPIC B. INTERMODAL PROJECT TITLE: A DECARBONIZED AND RESILIENT INTERMODAL FREIGHT TRANSPORTATION (DRIFT) MODELING PLATFORM FOR INTERMODAL LOGISTICAL DECISIONS UNDER UNCERTAINTY

NEW COOPERATIVE AGREEMENT