What is UNIVERSITY OF SOUTH CAROLINA's OSHA violation history?

UNIVERSITY OF SOUTH CAROLINA has 24 OSHA inspections on record with 34 violations and $18,103 in total penalties.

How does UNIVERSITY OF SOUTH CAROLINA's safety record compare to its industry?

UNIVERSITY OF SOUTH CAROLINA operates in the colleges, universities, and professional schools industry. The industry average Total Recordable Incident Rate (TRIR) is 1.3. UNIVERSITY OF SOUTH CAROLINA's self-reported DART rate is 1.07 compared to an industry average of 0.6.

Has UNIVERSITY OF SOUTH CAROLINA had any workplace fatalities?

Yes. Federal records show 1 fatality investigation involving UNIVERSITY OF SOUTH CAROLINA.

Establishment profile

UNIVERSITY OF SOUTH CAROLINA

301 MAIN STREET., COLUMBIA, SC, 29208
Operated by Aramark · 1 of 668 establishments
611310 — Colleges, Universities, and Professional Schools

Download as PDF →

OSHA inspections

over 39 years

Violations

$18,103 in penalties

SVEP

YES

Severe violator program

Violations across 2 federal agencies

Enforcement actions from multiple agencies may indicate systemic compliance issues across functions.

Accident investigations on record

1 fatality · 1 hospitalizations

Summary

UNIVERSITY OF SOUTH CAROLINA has accumulated 34 OSHA violations across 24 inspections over 39 years of recorded history, with $18,103 in total assessed penalties.

The establishment sits in the 100th percentile for violations within its industry-state peer group of 39 employers. Inspection frequency runs at the 100th percentile. The most recent enforcement activity was recorded 6 months ago.

Federal records were found in 2 of 15 sources. Sources without matching records returned empty for this establishment.

Agency coverage

UNIVERSITY OF SOUTH CAROLINA appears in OSHA workplace safety, WHD wage enforcement, and OFLC visa and labor certification (historical) records only. No matching records were found in MSHA mine safety, EPA environmental compliance, NLRB labor relations, FMCSA motor carrier registration, SAM.gov federal debarment, CMS nursing home enforcement, UVA Corporate Prosecution Registry, CPSC product recalls, or NHTSA vehicle recalls.

OSHA workplace safety

Inspections

0.6 / yr · last 39 yrs

Violations

0.9 / yr

Penalties

$18,103

$532 avg / violation

76% serious24% other

Inspection trigger · complaint

10 of 24

Inspection trigger · referral

4 of 24

29% of inspections at this establishment produced violations, with 6 inspections producing serious-or-greater violations.

Most-cited OSHA standards

Top OSHA standards cited at this employer, ranked by citation count. Standards (CFR sections) cluster citations into safety themes -- machine guarding, lockout-tagout, hazard communication, fall protection, process safety, etc. A concentration on one or two sections reveals a pattern that individual citations don’t. 20 distinct standards shown · 24 citations in this view · $18,103 in penalties.

CFR section	Citations	Inspections	Total penalty	First cited	Last cited
29 CFR 1926.1101 K02 II	2	2	$3,010	Jun 2002	May 2004
29 CFR 1910.0151 C	2	2	$770	Feb 1991	Oct 1992
29 CFR 1910.1450 E01	2	2	$763	Jul 1998	Jun 2002
29 CFR 1910.1200 H	2	2	$280	Feb 1991	Oct 1992
29 CFR 1926.1101 I01	1	1	$2,800	Jun 2002	Jun 2002
29 CFR 1926.1101 H01	1	1	$2,800	Jun 2002	Jun 2002
29 CFR 1926.1101 G08 I	1	1	$2,800	Jun 2002	Jun 2002
29 CFR 1910.0036 D01	1	1	$525	Apr 2002	Apr 2002
29 CFR 1910.0036 D02	1	1	$525	Apr 2002	Apr 2002
29 CFR 1910.1450 F03	1	1	$525	Jul 1998	Jul 1998
29 CFR 1910.1450 F04 I	1	1	$525	Jul 1998	Jul 1998
29 CFR 1910.0132 A	1	1	$525	Oct 1992	Oct 1992
29 CFR 1926.1101 D03	1	1	$400	Jun 2002	Jun 2002
29 CFR 1910.0134 B08	1	1	$375	Oct 1992	Oct 1992
29 CFR 1910.1200 G08	1	1	$375	Oct 1992	Oct 1992
29 CFR 1910.0305 D	1	1	$300	Apr 2002	Apr 2002
29 CFR 1910.1200 E01	1	1	$280	Feb 1991	Feb 1991
29 CFR 1910.1200 G01	1	1	$280	Feb 1991	Feb 1991
29 CFR 1910.0133 A01	1	1	$245	Feb 1991	Feb 1991
29 CFR 1910.0134 G01	1	1	—	May 2004	May 2004

Source: OSHA inspection citations (violation_detail). CFR section codes can be looked up at osha.gov/laws-regs for the formal standard text. Per-inspection detail and the specific violation descriptions are available by expanding individual inspections below.

Peer comparison

100th

Worse on violations than nearly every other employer in NAICS 6113 within SC. Peer group: 39 employers. This establishment has 34 OSHA violations; peer median is 0.

Fewer violationsMore violations

Penalty percentile

100th

peer median: $0

Inspection frequency

100th

peer median: 1

Safety self-report (OSHA 300A)

Recordable injury rates the employer filed with OSHA’s Injury Tracking Application. DART covers cases with days away, restricted, or transferred; TRIR is the total recordable case rate.

DART rate

1.1

vs industry

+0.5

TRIR

4.3

vs industry

+3.0

Reported for 295 average annual employees at this establishment.

Source: OSHA ITA Form 300A (employer self-reported). Rates are per 100 full-time equivalent workers. Establishments below the ~10-FTE threshold are not required to report.

Industry benchmark

Industry avg TRIR

1.3

BLS SOII 2024

Industry avg DART

0.6

BLS SOII 2024

Self-reported TRIR

4.3

OSHA ITA Form 300A (employer self-reported)

BLS rates reflect industry-wide averages. Self-reported figures come from OSHA’s Injury Tracking Application; absence of self-reported data does not necessarily indicate non-compliance — many establishments fall below the ITA reporting threshold.

Inspection breakdown

Planned

Complaint

Accident

Referral

Complaint- and accident-triggered inspections are stronger risk signals than routine planned inspections.

OSHA severe injury reports

No severe injury reports (hospitalization, amputation, or loss of an eye) on file under 29 CFR 1904.39 for UNIVERSITY OF SOUTH CAROLINA. Verify directly with Occupational Safety and Health Administration →

OSHA accident events

Accidents, fatalities, and catastrophes documented during OSHA inspections at this employer. Each entry links to the inspection that recorded it.

Date	Event	Injuries	Hospitalized	Fatalities
Jul 7, 1998	CAUSTIC,PPE,GLOVE,HYDROFLUORIC ACID,WORK RULES,CLEANING,SKIN,HAND,CHEMICAL	1	1	—
Mar 22, 1987	RESPIRATORY,INHALATION,SUICIDE,CARBON MONOXIDEFatality	1	—	1

Source: OSHA accident investigations. Narratives are recorded by the inspecting officer and may be truncated.

Activity timeline

Data refreshed

Weekly

First OSHA inspection

—

Most recent activity

6 months ago

Most recent federal enforcement activity recorded 6 months ago. Data on this page is refreshed weekly.

Wage & Hour Division (WHD)

Cases

Back wages owed

$2,585

Employees affected

Department of Labor Wage & Hour Division — minimum-wage, overtime, child-labor, FMLA, and prevailing-wage enforcement.

Wage and hour breakdown by law

Per-statute totals across all closed DOL Wage & Hour cases against this employer. Backwages reflect amounts the agency assessed; civil penalty is the separate fine where applicable. Some acts (Davis-Bacon, SCA, CWHSSA, H-2B, CCPA) don't carry a civil penalty field in DOL's data. 2 statutes · 3 violations · $2,585 in backwages

Statute	Period	Cases	Violations	Workers	Backwages	Civil penalty
H-1B visa wage protections	Sep 2017	1	2	1	$2,585	—
FMLA (family & medical leave)	Sep 2017	1	1	—	—	—

Source: DOL WHD enforcement database, aggregated per statute. Lifetime totals. A case can cite multiple statutes — so the total here may exceed the case count in the table above.

Wage and hour cases

Closed DOL Wage & Hour Division cases (FLSA, FMLA, H-2B, MSPA, and related statutes). Backwages reflect amounts the agency assessed; civil penalty (CMP) is a separate fine levied on top, where the statute provides for one (FLSA / H-1B / H-2A / MSPA / FMLA / EPPA / FLSA Child Labor; other acts have no CMP column in DOL’s data). The Statutes column lists which laws each case cited. 1 case · 3 violations · $2,585 in backwages · 1 worker affected

Case period	Industry	Statutes	Violations	Workers	Backwages	Civil penalty
Sep 2016 – Sep 2017	Colleges, Universities, and Professional Schools	FMLAH-1B	3	1	$2,585	—

Source: DOL WHD enforcement database. Cases shown reflect those the agency has closed and made public. A violation count is the agency’s tally of cited violations (one violation can affect many workers); the workers column counts distinct employees the agency found to be affected.

Mine safety (MSHA)

No MSHA mine safety violations on file for UNIVERSITY OF SOUTH CAROLINA. Verify directly with Mine Safety and Health Administration →

Labor relations (NLRB)

No NLRB unfair labor practice charges or union representation cases on file for UNIVERSITY OF SOUTH CAROLINA. Verify directly with National Labor Relations Board →

Visa & labor certification (OFLC) — historical

Total applications

Certified

Avg wage ratio

1.57x

H-1B

Office of Foreign Labor Certification — labor condition applications for H-1B, H-2A, H-2B visa programs. Wage ratio = offered / prevailing wage. Historical data only: DOL ended OFLC Performance Data Disclosure publication in 2026, so the figures above reflect filings through the last ingested cycle and are not being refreshed. Treat as a historical snapshot, not a current signal.

Environmental compliance (EPA)

No EPA inspections or formal enforcement actions on file for UNIVERSITY OF SOUTH CAROLINA. Verify directly with Environmental Protection Agency →

EPA-registered facilities

Every EPA ECHO facility associated with this employer, sorted most-significant first. Each row links to EPA’s Detailed Facility Report for the source-of-truth record. Permits column lists active programs (Air = Clean Air Act, Water = Clean Water Act, RCRA = hazardous waste, TRI = Toxics Release Inventory reporting). 2 facilities · 2 marked inactive.

Facility	Permits	Status	Inspections	Formal actions	Penalties	Last inspected	ECHO
UNIVERSITY OF SOUTH CAROLINA 306 BENSON SCHOOL · COLUMBIA, SC, 29208	—	—	0	0	—	—	View →
UNIVERSITY OF SOUTH CAROLINA BENSON SCHOOL ROOM 306 · COLUMBIA, SC, 29208	—	—	0	0	—	—	View →

Source: EPA ECHO (Enforcement and Compliance History Online). Compliance status follows EPA’s own labels (“Sig Violation” = significant noncompliance; QNCR = quarters of noncompliance over the recent reporting window). Inactive facilities (struck through) retain historical enforcement records even after operations ceased.

Federal criminal prosecution record

No federal criminal prosecutions, plea agreements, or deferred-prosecution agreements on file for UNIVERSITY OF SOUTH CAROLINA. Verify directly with UVA Corporate Prosecution Registry →

Federal contracts

This location

Obligated (5-yr)

$67.1M

Obligated (all-time)

$85.7M

Awards

171

Top agency

Department of Defense

$76.6M

Company-wide — UNIVERSITY OF SOUTH CAROLINA (across 8 entities)

Obligated (5-yr)

$55.5M

Obligated (all-time)

$85.1M

Awards (all-time)

216

Consolidated across all USAspending recipient entities under this corporate parent — not attributable to this single location.

Top agencies by obligation (this location)

Department of Defense$76.6M

Department of Transportation$4.0M

Department of Veterans Affairs$3.3M

Department of Health and Human Services$1.5M

Environmental Protection Agency$186K

Largest awards (top 50 of 171)

Department of Education
GRANT PROGRAM
assistance · Last action 2026-05-15
$41,327,288
Department of Health and Human Services
RESEARCH CENTER FOR CHILD WELL-BEING
assistance · Last action 2026-03-02
$11,162,883
Department of Commerce
LED BY THE UNIVERSITY OF SOUTH CAROLINA (USC), THE CAROLINA INSTITUTE FOR BATTERY INNOVATION (CIBI) WILL BOLSTER GRID RESILIENCE BY CATALYZING SC NEXUS' BATTERY ENERGY STORAGE SYSTEM (BESS) ECOSYSTEM THROUGH INVESTMENTS IN PILOT MANUFACTURING INFRASTRUCTURE AND WORKFORCE PROGRAMMING. ACCELERATING TIME TO MARKET FOR BESS TECHNOLOGIES IS CRITICAL TO SECURING THE U.S. GRID BY ENABLING ENHANCED LOAD STABILITY AND OUTAGE RECOVERY. ACTIVITIES TO BE PERFORMED: 1. USC, FRAUNHOFER, AND SIEMENS WILL COLLABORATE TO DESIGN AND INSTALL A PILOT MANUFACTURING LINE AT THE USC COLUMBIA CAMPUS WHICH WILL ENABLE TESTING AND COMMERCIALIZATION OF BATTERY ENERGY STORAGE SYSTEMS (BESS) TECHNOLOGIES. 2. DESIGN AND CREATE A DIGITAL ANALOG OF THE PHYSICAL PILOT MANUFACTURING LINE TO AID WITH CONFIGURATION AND PERFORMANCE OPTIMIZATION OVER TIME. 3. PROVIDE SMALLER SCALE MANUFACTURERS (SSMS) ACCESS TO MANUFACTURING INFRASTRUCTURE TO INTEGRATE INTO PRODUCTION PROCESSES AND TEST PERFORMANCE OF BESS INNOVATIONS. 4. DEVELOP AND DELIVER A MS-LEVEL CURRICULUM THAT INTIMATELY INTEGRATES BATTERY DESIGN AND MANUFACTURING. 5. DEVELOP AND DELIVER A TWO-YEAR DEGREE IN BATTERY TECHNICIAN TRAINING. EXPECTED OUTCOMES: CIBI?S PROGRAMMING WILL SUPPORT ECONOMIC AND NATIONAL SECURITY BY ACCELERATING THE SUPPLY OF DOMESTICALLY PRODUCED GRID-SCALE BATTERY TECHNOLOGIES AND THE WORKFORCE NECESSARY TO DEPLOY THEM. WITH THE COMBINED SUPPORT OF KEY PLAYERS IN SOUTH CAROLINA?S BATTERY ECOSYSTEM, CIBI WILL ALSO FIRMLY POSITION THE STATE AS A GLOBAL HUB OF GRID-SCALE BATTERY TECHNOLOGIES WITHIN THE NEXT TEN YEARS.
assistance · Last action 2024-12-16
$10,218,140
Department of Defense
THE PURPOSE OF THIS EFFORT IS TO PERFORM RESEARCH INTO DIGITAL TWIN TECHNOLOGIES FOR NAVY POWER AND ENERGY SYSTEMS (NPES).
contract · Last action 2023-11-30
$10,019,055
Department of Education
GAINING EARLY AWARENESS AND READINESS FOR UNDERGRADUATE PROGRAMS (GEAR UP) SOUTH CAROLINA STATE GRANT
assistance · Last action 2025-09-19
$9,999,954
Department of Defense
THIS PROJECT WILL DEVELOP AND DEMONSTRATE THE APPLICATION OF DIGITAL TWIN TECHNOLOGIES FOR NAVY POWER AND ENERGY SYSTEMS, PRIMARILY BY PROVIDING ADVANCED CONTROLS AND USER DECISION AIDS APPLICABLE TO USE CASES PERTINENT TO THE NAVY.
contract · Last action 2023-11-13
$9,997,059
Department of Defense
DIGITAL TWINS FOR RESILIENT POWER AND ENERGY SYSTEMS
contract · Last action 2023-08-16
$9,964,825
Department of Health and Human Services
USC PRC CENTER AND CORE RESEARCH PROJECT: NATIONAL IMPLEMENTATION STUDY OF THE FAITH, ACTIVITY, AND NUTRITION (FAN) PROGRAM
assistance · Last action 2026-04-24
$7,787,424
Department of Defense
THIS EFFORT WILL ADVANCE THE STATE-OF-THE-ART IN COMPUTER PERCEPTION SYSTEMS THAT COMBINES PRIMARILY ELECTRO-OPTICAL (EO), INFRARED (IR), AND RADAR TO PROVIDE AN AUTOMATED, RELIABLE PERCEPTION CAPABILITY FOR UNMANNED SURFACE VESSELS OPERATING IN LITT
contract · Last action 2023-08-09
$7,140,000
Department of Defense
AUTONOMOUS MARITIME PERCEPTION
contract · Last action 2024-04-19
$7,040,000
Department of Education
GRANT PROGRAM
assistance · Last action 2025-09-04
$6,436,971
Department of Education
GRANT PROGRAM
assistance · Last action 2026-05-20
$5,545,232
Department of Health and Human Services
WHAT'S UP (UNDERMINING PREVENTION) WITH SUMMER? ETIOLOGY OF ACCELERATED WEIGHT GAIN DURING SUMMER VS. SCHOOL YEAR
assistance · Last action 2025-06-19
$5,176,748
Department of Health and Human Services
THE CENTER FOR CLINICAL AND TRANSLATIONAL RESEARCH AT THE UNIVERSITY OF SOUTH CAROLINA (CLINTRUSC) - SUMMARY THE INCIDENCE OF CHRONIC DISEASES SUCH AS METABOLIC DISEASE, CARDIOVASCULAR DISEASE, CANCER, NEURODEGENERATIVE DISEASE REMAIN PERSISTENTLY HIGH IN SOUTH CAROLINA AND ARE DISPROPORTIONALLY GREATER IN THE CENTRAL REGION OF THE STATE-CALLED THE MIDLANDS. THE OVERARCHING GOAL OF THIS CENTER FOR TRANSLATIONAL RESEARCH DEVELOPMENT (CTR-D) PROGRAM IS TO ADDRESS THIS UNMET NEED BY BUILDING A SUSTAINABLE FOUNDATION OF CLINICAL AND TRANSLATIONAL RESEARCH CAPACITY AT THE UNIVERSITY OF SOUTH CAROLINA (USC) WHICH IS GEOGRAPHICALLY POSITIONED IN THE MIDDLE OF THE STATE (MIDLANDS), NAMELY THE CENTER FOR CLINICAL AND TRANSLATIONAL RESEARCH AT USC- CLINTRUSC. WE WILL LEVERAGE EXISTING CLINICAL/TRANSLATIONAL RESEARCH EXPERTISE WITHIN THE USC SCHOOL OF MEDICINE, NATIONALLY RECOGNIZED HEALTH SCIENCE RESEARCH WITHIN THE USC SCHOOL OF PUBLIC HEALTH, THE SCHOOL OF PHARMACY, COLLEGE OF NURSING AND THE SCHOOL OF SOCIAL WORK, WHICH WILL ALLOW US TO TAP INTO AN IMPORTANT RESEARCH WORK FORCE THAT EXTENDS BEYOND THE USUAL CONFINES OF ACADEMIC MEDICINE-BASED CLINICAL TRIAL INFRASTRUCTURE. THIS ALSO WILL ALLOW US TO ENGAGE MEANINGFULLY WITH HIGH-RISK COMMUNITIES THAT MAY BE INACCESSIBLE OR RESISTANT TO MORE CONVENTIONAL APPROACHES. MOREOVER, WE WILL ENGAGE OUR HEALTH SYSTEMS PARTNERS; PRISMA HEALTH (THE LARGEST HEALTH CARE PROVIDER IN THE STATE) AND THE VETERANS ADMINISTRATION (VA) HEALTH SYSTEM TO DEVELOP A CENTRALIZED, COHESIVE APPROACH TO PERFORM CLINICAL AND TRANSLATIONAL RESEARCH THROUGHOUT THE MIDLANDS OF SOUTH CAROLINA. THE CLINTRUSC PROGRAM WILL DEVELOP THE 5 ESSENTIAL CORES REQUIRED FOR A CTR-D WHICH WILL RESULT FOR THE FIRST TIME AT USC, A COHESIVE INFRASTRUCTURE TO QUICKLY DEPLOY CLINICAL/TRANSLATIONAL RESEARCH PROJECTS WITHIN THE MIDLANDS WITH A PARTICULAR FOCUS ON ENGAGING VULNERABLE PATIENT POPULATIONS (UNDERSERVED, VETERANS).
assistance · Last action 2026-02-19
$5,108,462
Department of Education
PROVIDING RESOURCES TO INCREASE SCHOOL MENTAL HEALTH SUPPORTS
assistance · Last action 2025-12-08
$5,003,364
Department of Defense
RELIABLE PERCEPTION FOR UNMANNED MARITIME SYSTEMS
contract · Last action 2021-11-10
$4,750,000
Department of Health and Human Services
ASH1L MEDIATED TRANSCRIPTION NETWORKS IN AUTISM SPECTRUM DISORDERS - ABSTRACT GENETIC RESEARCH IN AUTISM SPECTRUM DISORDER (ASD) HAS LED TO THE DISCOVERY OF A GROWING LIST OF HIGHLY PENETRANT MUTATIONS IN CHROMATIN MODIFIERS AND TRANSCRIPTION FACTORS. THIS RECENT PROGRESS PROVIDES AN IMPORTANT OPPORTUNITY TO DEFINE THE MOLECULAR MECHANISMS IN ASD, AS WELL AS TO IDENTIFY TARGETS FOR NEW TREATMENT STRATEGIES. HOWEVER, GIVEN THE LARGE NUMBER OF SEEMINGLY INDEPENDENT ASD RISK FACTORS, A MAJOR CHALLENGE FOR ASD RESEARCH IS TO ESTABLISH CONVERGENT MECHANISMS THAT GROUP APPARENTLY DISTINCT GENETIC ETIOLOGIES. WE IDENTIFIED A NOVEL POINT OF CONVERGENCE BETWEEN THE HISTONE-METHYLTRANSFERASE ASH1L, A MAJOR ASD GENETIC RISK FACTOR, AND A CLUSTER OF ASD HIGH-RISK GENES (E.G. FOXP1, RIMS1, NRX1A). WE ALSO FIND THAT ASH1L COUNTERACTS THE ACTIVITY OF POLYCOMB REPRESSOR COMPLEX IN NEURAL DEVELOPMENT. HENCE, OUR DATA UNCOVER A TRANSCRIPTIONAL AND EPIGENETIC NODE LINKED TO CELL AND CIRCUIT DYSFUNCTION UNDERLYING ASD PHENOTYPES. HOWEVER, THE TRANSCRIPTIONAL PROGRAMS MODULATED BY ASH1L THAT LEAD TO NEURONAL DYSFUNCTION ARE UNDERSTUDIED. OUR CENTRAL HYPOTHESIS IS THAT ASH1L COUNTERACTS POLYCOMB ACTIVITY TO ORCHESTRATE NEURONAL DEVELOPMENT BY MODULATING TRANSCRIPTIONAL PROGRAMS THAT CONTROL SYNAPTIC FUNCTION AND NEURONAL MORPHOGENESIS. WE WILL DEFINE HOW ASH1L REGULATES NEURONAL DEVELOPMENT AND FUNCTION. WE WILL USE A MULTILEVEL, SYNERGISTIC AND TRANSLATIONAL APPROACH THAT LEVERAGES HUMAN AND MOUSE SYSTEMS TO DETERMINE HOW ASH1L MODULATES NEURONAL PROGRAMS RELEVANT TO ASD PATHOGENESIS. WE ARE POSITIONED TO UNDERTAKE THIS WORK, BASED ON OUR ROBUST PRELIMINARY DATA AND COMBINED EXPERTISE IN CELLULAR/MOLECULAR NEUROSCIENCE, BIOINFORMATIC, CHROMATIN BIOLOGY AND ELECTROPHYSIOLOGY. 1) DETERMINE HOW MUTATIONS IN ASH1L DISRUPT NEURONAL ARBORIZATION AND FUNCTION IN HUMAN STEM CELL EXPERIMENTAL SYSTEMS, 2) DEFINE FUNCTIONAL AND CIRCUIT PHENOTYPES ASSOCIATED WITH ASH1L IN RODENT SYSTEMS. 3) DEFINE BULK AND CELL TYPE SPECIFIC EPIGENETIC AND TRANSCRIPTIONAL SIGNATURES ASSOCIATED WITH ASH1L MUTATIONS THAT CAUSE DISEASE IN MOUSE AND HUMAN NEURONS. FINALLY, WE WILL DEFINE RESCUE STRATEGIES FOR THE CELLULAR, MOLECULAR, AND ELECTROPHYSIOLOGICAL PHENOTYPES OBSERVED IN BOTH MOUSE AND HUMAN EXPERIMENTAL SYSTEMS.
assistance · Last action 2025-12-19
$4,727,601
Department of Health and Human Services
COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION
assistance · Last action 2023-11-16
$4,500,000
Department of Health and Human Services
PATTERNS AND PREDICTORS OF VIRAL SUPPRESSION: A BIG DATA APPROACH - ABSTRACT VIRAL SUPPRESSION IS THE FINAL STAGE OF THE HIV TREATMENT CASCADE, WHICH SERVES AS THE FRAMEWORK FOR UNAIDS’ 90-90-90 GOALS. SUSTAINED VIRAL SUPPRESSION IS ONE OF FOUR STRATEGIC AREAS OF THE “ENDING THE HIV EPIDEMIC (ETHE): A PLAN FOR AMERICA” FEDERAL CAMPAIGN, LAUNCHED IN FEBRUARY 2019, WHICH AIMS FOR THE REDUCTION OF NEW HIV INFECTIONS IN THE UNITED STATES (US) BY 75% AND 90% BY 2025 AND 2030, RESPECTIVELY. THE ETHE CAMPAIGN FOCUSES ON 48 US COUNTIES AND 7 STATES, INCLUDING SOUTH CAROLINA (SC). GIVEN THE IMPORTANCE OF VIRAL SUPPRESSION IN ENDING THE US HIV EPIDEMIC, AN OPTIMAL PREDICTIVE MODEL OF VIRAL STATUS CAN HELP CLINICIANS IDENTIFY THOSE AT RISK OF POOR VIRAL CONTROL AND INFORM CLINICAL IMPROVEMENTS IN HIV TREATMENT AND CARE. VARIOUS INDICATORS TO CHARACTERIZE THE LONGITUDINAL VIROLOGIC OUTCOMES HAVE BEEN PROPOSED IN THE LITERATURE SUCH AS SUSTAINED VIRAL SUPPRESSION, VIRAL REBOUND, LOW-LEVEL VIRAEMIA (LLV), PERSISTENT LLV, AND VIROLOGIC BLIPS. HOWEVER, SOME CRITICAL GAPS STILL EXIST IN OUR EFFORTS TO DEVELOP AN OPTIMAL PREDICTIVE MODEL OF VIRAL SUPPRESSION. THESE GAPS INCLUDE THE USE OF LIMITED INDICATORS OF VIROLOGIC OUTCOMES, LIMITED DURATION OF FOLLOW-UP, LIMITED DATA SOURCES, LACK OF CONSIDERATION OF STRUCTURAL AND SOCIOENVIRONMENTAL DATA, SMALL OR UNREPRESENTATIVE SAMPLES OF PEOPLE LIVING WITH HIV (PLWH), AND LIMITED EFFORTS TO TRANSLATE RESEARCH FINDINGS INTO SERVICE-READY TOOLS FOR CLINICAL USE. WITH NIH SUPPORT (R01AI127203) SINCE 2017, WE HAVE UTILIZED A BIG DATA APPROACH TO EXAMINE TREATMENT GAPS (E.G., MISSED OPPORTUNITIES FOR DIAGNOSIS AND LINKAGE TO CARE) AMONG A STATEWIDE COHORT OF PLWH IN SC. THIS ONGOING RESEARCH EXTRACTED LONGITUDINAL ELECTRONIC HEALTH RECORDS DATA FROM SIX STATE AGENCIES AND THEN LINKED THE PATIENT-LEVEL DATA WITH COUNTY-LEVEL DATA (E.G., SOCIOECONOMIC INDICATORS, NUMBER OF HEALTH CARE PROFESSIONALS, HOSPITALS, AND HEALTH CARE FACILITIES) FROM MULTIPLE PUBLICLY AVAILABLE DATA SOURCES. THE RESULTANT INTEGRATED DATABASE HAS ENABLED US TO SUCCESSFULLY “TRACK” 11,470 PATIENTS WHO WERE DIAGNOSED WITH HIV FROM 2005 TO 2016 IN SC AND IDENTIFY THE GAPS IN HIV TREATMENT LINKAGE AND RETENTION. BASED ON THE EXPERIENCE AND ACCOMPLISHMENT OF THE R01AI127203, WE SUBMIT THIS APPLICATION TO EXAMINE THE LONGITUDINAL DYNAMIC PATTERN OF VIRAL SUPPRESSION, DEVELOP OPTIMAL PREDICTIVE MODELS OF VARIOUS VIRAL SUPPRESSION INDICATORS, AND TRANSLATE THE MODELS TO SERVICE-READY TOOLS FOR CLINICAL USE. IN THE PROPOSED RESEARCH, WE WILL: 1) CONTINUE TO “FOLLOW” OUR COHORT FOR ANOTHER FIVE YEARS (AND ALSO EXPAND THE COHORT BY ADDING PLWH DIAGNOSED BETWEEN 2016-2020); 2) EXPAND OUR DATABASE TO INCLUDE ADDITIONAL DATA ON CRITICAL PREDICTORS OF VIRAL SUPPRESSION (E.G., TREATMENT AND LABORATORY DATA, ALCOHOL AND SUBSTANCE USE DATA) FROM TWO NEWLY PARTICIPATING STATEWIDE DATA SOURCES; 3) EMPLOY ARTIFICIAL INTELLIGENCE (AI)-BASED MODELING TO UNDERSTAND THE DYNAMIC VIRAL LOAD PATTERNS AND THEIR PREDICTORS; AND 4) DEVELOP AND PILOT-TEST A MULTIFACTORIAL DECISION SYSTEM FOR CLINICAL USE. THE RESULTS WILL ENABLE THE IDENTIFICATION OF PLWH WITH POOR VIRAL CONTROL AND SUGGEST “WHEN” AND “HOW” TO HELP THOSE PLWH ACHIEVE AND MAINTAIN VIRAL SUPPRESSION. THE PROPOSED RESEARCH WILL IMPROVE OUR UNDERSTANDING OF THE LONGITUDINAL DYNAMICS OF VIRAL SUPPRESSION AND INFORM TAILORED HIV CARE MANAGEMENT AMONG PLWH IN SC AND BEYOND.
assistance · Last action 2026-03-24
$4,380,945
Department of Health and Human Services
ADVANCED NURSING EDUCATION WORKFORCE
assistance · Last action 2026-03-12
$4,332,212
Department of Health and Human Services
RURAL HEALTH RESEARCH GRANT PROGRAM COOPERATIVE AGREEMENT
assistance · Last action 2025-12-16
$4,324,340
Department of the Interior
15.904 HISTORIC PRESERVATION FUND GRANTS-IN-AID AACR PRESERVATION SAM.GOV HISTORIC PRESERVATION FUND GRANTS-IN-AID ASSIST IN THE IDENTIFICATION, EVALUATION, AND PROTECTION OF HISTORIC PROPERTIES BY SUCH MEANS AS EDUCATION, SURVEY, PLANNING, TECHNICAL ASSISTANCE, PRESERVATION, DOCUMENTATION, AND FINANCIAL INCENTIVES LIKE GRANTS AND TAX CREDITS AVAILABLE FOR HISTORIC PROPERTIES. OPPORTUNITY P23AS00472 AFRICAN AMERICAN CIVIL RIGHTS (AACR) IS A COMPETITIVE PHYSICAL PRESERVATION GRANT PROGRAM TO DOCUMENT, INTERPRET, AND PRESERVE THE SITES AND STORIES OF THE FULL HISTORY OF THE AFRICAN AMERICAN STRUGGLE TO GAIN EQUAL RIGHTS AS CITIZENS FROM THE TRANSATLANTIC SLAVE TRADE FORWARD. PROJECTS ARE FOR HISTORIC SITES LISTED IN, OR ELIGIBLE FOR LISTING IN THE NATIONAL REGISTER, AND INCLUDE ARCHITECTURAL SERVICES, HISTORIC STRUCTURE REPORTS, PRESERVATION PLANS, AND PHYSICAL PRESERVATION TO STRUCTURES. BENEFICIARIES INCLUDE STATES, TRIBES, LOCAL GOVERNMENTS, AND NONPROFITS. THIS PROJECT IS AWARDED TO THE UNIVERSITY OF SOUTH CAROLINA TO REHABILITATE THE FLORENCE C. BENSON ELEMENTARY SCHOOL.
assistance · Last action 2024-08-09
$4,250,000
Department of Defense
BAA 20-0114 - YEAR 1, THE USE OF BIOPOLYMERS TO STRENGTHEN EARTHEN INFRASTRUTURE
contract · Last action 2024-08-21
$4,000,000
Department of Health and Human Services
THE TOGETHER EVERYONE ACHIEVES MORE PHYSICAL ACTIVITY TRIAL (TEAM-PA) - PROJECT SUMMARY/ABSTRACT AFRICAN AMERICAN (AA) WOMEN EXPERIENCE DISPROPORTIONATELY HIGHER RATES OF CHRONIC DISEASES COMPARED TO WHITE WOMEN, INCLUDING BEING TWICE AS LIKELY TO DIE FROM CARDIOVASCULAR DISEASE. PHYSICAL ACTIVITY (PA) IS A KEY PROTECTIVE FACTOR FOR REDUCING RISK FOR CHRONIC DISEASES, YET ONLY 35% OF AA WOMEN MEET NATIONAL PA GUIDELINES. PERSISTENT DISPARITIES IN CHRONIC DISEASE AND PRE-MATURE DEATH AMONG AFRICAN AMERICAN WOMEN ACROSS THE ADULT LIFESPAN HIGHLIGHT THE NEED FOR DEVELOPING EFFECTIVE INTERVENTIONS FOR INCREASING PA AMONG AA WOMEN. WE PROPOSE THAT COMMUNITY SETTINGS HOLD TREMENDOUS PROMISE AS AN IMPORTANT CONTEXT FOR REACHING AA WOMEN, BUT THE ROLE OF SOCIAL AFFILIATION HAS BEEN UNDERSTUDIED IN PAST COMMUNITY-BASED INTERVENTIONS AS A KEY MECHANISM FOR ENGAGING AA WOMEN IN LONG-TERM PA. A VARIETY OF THEORIES HAVE HIGHLIGHTED THE IMPORTANCE OF SOCIAL AFFILIATION FOR HEALTH PROMOTION AND HAVE DEFINED SOCIAL AFFILIATION THROUGH SEVERAL DISTINCT BUT RELATED CONSTRUCTS. SOCIAL COGNITIVE THEORY (SCT) PROPOSES THAT THE GROUP CONTEXT PROMOTES SOCIAL LEARNING AND COLLECTIVE EFFICACY, WHILE SELF-DETERMINATION THEORY (SDT) AND GROUP DYNAMICS THEORY (GDT) HAVE EMPHASIZED THE IMPORTANCE OF POSITIVE INTERACTIONS BETWEEN GROUP MEMBERS IN ORDER TO PROMOTE RELATEDNESS, RECIPROCAL SUPPORT, AND GROUP COHESION. SOCIAL AFFILIATION WITHIN GROUP-BASED PROGRAMS MAY BE ESPECIALLY IMPORTANT TO AA WOMEN, GIVEN THAT COLLECTIVISM (BELIEF IN THE IMPORTANCE OF ADVANCING THE GROUP OVER THE INDIVIDUAL) IS A PROMINENT CULTURAL VALUE FOR MANY AAS. DESPITE CONVERGING EVIDENCE HIGHLIGHTING THE IMPORTANCE OF SOCIAL AFFILIATION FROM A MOTIVATIONAL AND CULTURAL PERSPECTIVE, THIS FACTOR HAS BEEN MINIMALLY INTEGRATED WITHIN INTERVENTION DESIGNS AND RARELY TARGETED AS A CENTRAL MECHANISM FOR INCREASING PA. OUR INVESTIGATIVE TEAM PROVIDES STRONG PRELIMINARY DATA FOR EXPANDING ON PREVIOUS COMMUNITY-BASED PA INTERVENTIONS FOR INACTIVE AA WOMEN BY TARGETING SOCIAL AFFILIATION THROUGH A COMBINATION OF COLLABORATIVE AND COMPETITIVE STRATEGIES. DRAWING FROM SDT, SCT, GDT, AND A CULTURAL VALUES FRAMEWORK, THE TOGETHER EVERYONE ACHIEVE MORE PHYSICAL ACTIVITY (TEAM-PA) TRIAL EVALUATES THE EFFICACY OF A GROUP-BASED SOCIAL AFFILIATION INTERVENTION (VS. A STANDARD GROUP-DELIVERED PA COMPARISON PROGRAM) FOR INCREASING PA AMONG INACTIVE AA WOMEN. USING A GROUP COHORT RANDOMIZED DESIGN IMPLEMENTED AT COMMUNITY CENTERS ACROSS FIVE YEARS, THE PRIMARY AIM OF THIS STUDY IS TO EVALUATE THE EFFICACY OF THE 10-WEEK TEAM-PA GROUP-BASED INTERVENTION (VS. COMPARISON PROGRAM) ON INCREASING ACCELEROMETRY-ASSESSED MINUTES PER DAY OF TOTAL PA (LIGHT TO VIGOROUS ACTIVITIES) FROM BASELINE TO POST-INTERVENTION AND MAINTENANCE AT A 6-MONTH FOLLOW-UP [PRIMARY AIM 1]. ADDITIONALLY, WE WILL EVALUATE THE IMPACT OF THE TEAM-PA INTERVENTION ON SECONDARY OUTCOMES (PERCENTAGE MEETING NATIONAL RECOMMENDATIONS FOR PA, LIGHT PA, SEDENTARY BEHAVIOR, BODY MASS INDEX, BLOOD PRESSURE) [SECONDARY AIMS 1-2] AND POTENTIAL MEDIATORS OF THE INTERVENTION EFFECT ON CHANGES IN PA [SECONDARY AIM 3].
assistance · Last action 2026-05-12
$3,943,723
Department of Health and Human Services
NEXT GENERATION MOSQUITO CONTROL THROUGH TECHNOLOGY-DRIVEN TRAP DEVELOPMENT AND ARTIFICIAL INTELLIGENCE GUIDED DETECTION OF MOSQUITO BREEDING HABITATS - PROJECT SUMMARY EACH YEAR, APPROXIMATELY 400 MILLION PEOPLE ARE INFECTED WITH AN ARBOVIRAL DISEASE FROM THE BITE OF AN AEDES SPP MOSQUITO. AEDES SPP. MOSQUITOES ARE A LEADING PUBLIC HEALTH THREAT DUE TO THEIR HIGH COMPETENCY TO VECTOR MULTIPLE PATHOGENS, THEIR PREFERENCE TO BITE HUMANS, AND THEIR ABILITY TO ADAPT TO NEW DOMESTIC ENVIRONMENTS. IN THE US, REINTRODUCTION AND ESTABLISHMENT OF AEDES AEGYPTI AND AEDES ALBOPICTUS MOSQUITO POPULATIONS HAS RESULTED IN LOCAL EPIDEMICS OF ZIKA, DENGUE AND CHIKUNGUNYA IN THE PAST DECADE. UNFORTUNATELY, MOSQUITO CONTROL PROGRAMS IN THE US GENERALLY OPERATE WITH LIMITED BUDGETS, FORCING THE MAJORITY OF INSECTICIDE SPRAYING TO BE CONDUCTED IN REACTION TO POPULATION EXPOSURE INSTEAD OF TARGETED PREVENTION, WHICH HAS ALSO CONTRIBUTED TO CONSIDERABLE GROWTH OF INSECTICIDE RESISTANT POPULATIONS, YIELDING A WIDENING GAP OF INFRASTRUCTURE VULNERABILITY. OUR CURRENT PROPOSAL AIMS TO LEVERAGE EXISTING TECHNOLOGIES FROM NON-HEALTH DISCIPLINES TO ADVANCE MOSQUITO DETECTION AND ABATEMENT. WE PROPOSE TO VALIDATE THE USE OF TECHNOLOGY-DRIVEN MOSQUITO TRAPS THAT ALLOW FOR HIGH- THROUGHPUT IDENTIFICATION AND COUNTING OF AEDES MOSQUITOS AT VARIOUS LIFE STAGES TO INFORM DECISION MAKING WHEN SELECTING AREAS FOR INSECTICIDE SPRAYING AND ABATEMENT. ADDITIONALLY, WE PROPOSE TO DEVELOP RIGOROUS REMOTE SENSING WORKFLOWS FOR IDENTIFICATION OF NEIGHBORHOOD-LEVEL AEDES ABUNDANCE RISK AND RAPID DETECTION OF INDIVIDUAL AEDES MOSQUITO BREEDING HABITATS ON A HOUSEHOLD-LEVEL. THIS INNOVATIVE PROPOSAL USES MULTI-YEAR AND REAL-WORLD MOSQUITO DATA FROM TWO DIFFERENT METROPOLITAN AREAS TO STATISTICALLY ADJUST FOR VARIANCES IN GEOGRAPHIC ECOLOGIES, URBAN MICROCLIMATES, SEASONAL CLIMATE PATTERNS, AND ANNUAL WEATHER EVENTS. OUR STUDY WILL RESULT IN LOW-COST TOOLS IMMEDIATELY READY FOR BROAD DISTRIBUTION AND INTEGRATION BY VECTOR CONTROL AGENCIES NATIONALLY. THE OUTCOMES OF OUR STUDY HAVE PROMISE TO DIRECTLY IMPACT VECTOR CONTROL AGENCY’S DECISION-MAKING PROCESSES FOR MOSQUITO TRAPPING SITE SELECTION, INFORM PREVENTATIVE ABETMENT PROTOCOLS, AND SHORTEN THE TIME REQUIRED FOR MOSQUITO COLLECTION AND IDENTIFICATION. FURTHER, INTEGRATION OF OUR PROPOSED TECHNOLOGY TRAPS AND INFORMED SITE SELECTION MAPS WILL INCREASE OVERALL COLLECTION VOLUMES WHILE PRESERVING SCARCE RESOURCES FOR LOCAL VECTOR CONTROL AGENCIES. THIS PROPOSAL HAS THE POTENTIAL TO CREATE A PARADIGM SHIFT IN HOW WE APPROACH VECTOR CONTROL GLOBALLY, WITH A TARGETED INTERVENTION RESULTING IN SIGNIFICANT ECONOMIC, ENVIRONMENTAL, AND CLINICAL BENEFITS.
assistance · Last action 2025-08-22
$3,914,766
Department of Health and Human Services
EXPANDING THE REACH OF THE NUTRITIOUS EATING WITH SOUL (NEW SOUL) PROGRAM: A TYPE 2 HYBRID EFFECTIVENESS-IMPLEMENTATION TRIAL - PROJECT SUMMARY/ABSTRACT AFRICAN AMERICANS (AAS) ARE DISPROPORTIONATELY AFFECTED BY CARDIOVASCULAR DISEASE (CVD) AND OBESITY. AA VEGETARIANS/VEGANS HAVE SIGNIFICANTLY LOWER RISKS OF HYPERTENSION AND DIABETES AS COMPARED TO AA OMNIVORES. VEGAN SOUL FOOD RESTAURANTS HAVE EMERGED AS A POTENTIAL COMMUNITY PARTNER FOR INTRODUCING PATRONS TO HEALTHY VERSIONS OF FAMILIAR SOUL FOOD CUISINE. TO EXPLORE THE POTENTIAL IMPACT OF THIS INTERVENTION ON AAS WITH OVERWEIGHT OR OBESITY WHO WERE NOT ALREADY FOLLOWING VEGAN DIETS, WE CONDUCTED THE NUTRITIOUS EATING WITH SOUL INTERVENTION (NEW SOUL; R01HL135220), DELIVERED IN A UNIVERSITY SETTING IN COLUMBIA, SC (N=159 AAS; VEGAN VS. LOW-FAT OMNIVOROUS DIET, BOTH FOCUSED ON SOUL FOOD). WE COMPLETED 3-MONTH ASSESSMENTS WITH HIGH RETENTION RATES (88%) AND SIGNIFICANT WEIGHT LOSS (VEGAN -2.2±2.8 KGS; OMNIVOROUS -1.2±2.7 KGS; P=0.03). WE PROPOSE TO EXAMINE THE EFFECTIVENESS AND IMPLEMENTATION OF A REMOTELY-DELIVERED, 3-MONTH NEW SOUL PROGRAM. WE WILL WORK WITH TWO VEGAN SOUL FOOD RESTAURANTS (SEE LETTERS OF SUPPORT). WE HAVE THE FOLLOWING AIMS: AIM 1: EVALUATE THE EFFECTIVENESS OF THE 3-MONTH NEW SOUL RESTAURANT-DELIVERED PROGRAM ON TWO IMPORTANT FACTORS IN THE DEVELOPMENT OF CVD (BODY WEIGHT AND DIET QUALITY) AMONG AAS WITH OVERWEIGHT OR OBESITY. PARTICIPANTS (N=228) WILL BE RANDOMIZED TO ONE OF TWO CONDITIONS: 1. REMOTELY DELIVERED LIVE WEEKLY CLASSES WITH RESTAURANT VOUCHERS (INTERVENTION) OR 2. RESTAURANT VOUCHER-ONLY (ACTIVE CONTROL). AIM 2: CONDUCT A COST-EFFECTIVENESS ANALYSIS OF DELIVERING THE ONLINE INTERVENTION PLUS VOUCHER VS. VOUCHER- ONLY WITH THE OUTCOME OF COST/CHANGE IN WEIGHT, HEI AND QUALITY ADJUSTED LIFE YEAR (QALY). THIS INCLUDES ESTIMATING COSTS OF THE INTERVENTION ITSELF (E.G., TRAINING, DELIVERY, INFRASTRUCTURE). AIM 3A: EXAMINE THE IMPLEMENTATION OF THE NEW SOUL STUDY. GUIDED BY THE IMPLEMENTATION OUTCOME FRAMEWORK BY PROCTOR, ET. AL., AND THE IMPLEMENTATION STRATEGIES DESCRIBED BY WALTZ, ET. AL., WE WILL EXAMINE THE FEASIBILITY AND UTILITY OF THE NEW SOUL IMPLEMENTATION STRATEGIES (E.G., PROVIDE ITERATIVE ASSISTANCE, PROVIDE ONGOING TRAINING AND CONSULTATION, CENTRALIZE TECHNICAL ASSISTANCE) IN RESTAURANT SETTINGS. WE WILL EMPLOY QUALITATIVE (SEMI-STRUCTURED INTERVIEWS WITH INTERVENTION STAFF AND FOCUS GROUPS WITH PARTICIPANTS), AND QUANTITATIVE (SURVEYS WITH PARTICIPANTS) RESEARCH METHODS, WHICH WILL BE GUIDED BY CFIR DOMAINS (INTERVENTION CHARACTERISTICS, INNER SETTING, OUTER SETTING, CHARACTERISTICS OF INDIVIDUALS, AND PROCESS). AIM 3B: BUILDING ON THE FINDINGS FROM AIMS 1-3A, WE WILL CONDUCT KEY INFORMANT INTERVIEWS WITH INTERVENTION AND RESTAURANT STAFF TO IDENTIFY AREAS TO PREPARE THE INTERVENTION FOR WIDESPREAD ADOPTION BY VEGAN SOUL FOOD RESTAURANTS ACROSS THE SOUTHEAST. WE WILL FOCUS ON THE DESIGN QUALITY AND PACKAGING, PART OF THE CFIR “INTERVENTION CHARACTERISTICS” DOMAIN.
assistance · Last action 2026-02-20
$3,593,644
Department of Health and Human Services
A TRANSDISCIPLINARY APPROACH TO INVESTIGATING METABOLIC DYSREGULATION IN OBESE PARENT AND CHILD DYADS AND RISK OF COLORECTAL CANCER - THIS U01 PROJECT LEVERAGES OUR EXPERTISE IN THE EPIDEMIOLOGY OF COLORECTAL CANCER (CRC); DISPARITIES; OBESITY; METABOLIC DYSREGULATION, AN IMPORTANT MANIFESTATION OF INFLAMMATION; THE MICROBIOME; ANIMAL CRC MODELS; AND LIFESTYLE INTERVENTION TRIALS TO ADDRESS THE GROWING PROBLEM OF EARLY-ONSET CRC (EOCRC) (I.E., <50 YEARS). ADIPOSITY AND DIET DRIVE METABOLIC DYSREGULATION. SO, UNDERSTANDING THE INTERACTION BETWEEN DIET AND ADIPOSITY ARE KEY TO UNDERSTANDING THE GENESIS OF EOCRC – AND AN ARRAY OF OTHER OBESITY-RELATED CANCERS). THIS PROJECT WILL ADDRESS THE ABSENCE OF CRITICAL CLINICAL TRIALS AND MECHANISTIC STUDIES INVOLVING LIFESTYLE INTERVENTIONS FOR EOCRC. WE INTEND TO ADDRESS THIS GAP; AND HAVE THE TRANSDISCIPLINARY TEAM REPRESENTING COMPLEMENTARY BACKGROUNDS TO DO SO. WE FOCUS ON DIETARY MODULATION OF GUT MICROBES TO REDUCE METAFLAMMATION AND SUBSEQUENT METABOLIC DYSFUNCTION IN OBESITY, WITH A GOAL OF PREVENTING EOCRC. WE WILL PERFORM 1) AN ANTI- INFLAMMATORY DIETARY INTERVENTION TRIAL IN DYADS OF ADULTS AND CHILDREN AT ELEVATED RISK FOR CRC. WE ALSO WILL CONDUCT A COMPLEMENTARY MECHANISTIC ANIMAL STUDY THAT BUILDS ON AND LEVERAGES OUR EXPERTISE IN MECHANISTIC STUDIES ON OBESITY AND CRC. THIS WORK IS SUPPORTED BY INFRASTRUCTURE THAT WE HAVE BUILT OVER THE PAST DECADES IN TWO KEY CENTERS AT THE UNIVERSITY OF SOUTH CAROLINA (UOFSC): (1) CENTER FOR COLON CANCER RESEARCH (CCCR, 2002 - PRESENT – WHICH SPECIALIZES IN MOUSE MODELS OF CRC); AND (2) THE CANCER PREVENTION AND CONTROL PROGRAM (CPCP, 2000 - PRESENT – WHICH SPECIALIZES IN THE EPIDEMIOLOGY OF CANCER AND LIFESTYLE INTERVENTION TRIALS FOR CANCER, WITH A FOCUS ON CANCER DISPARITIES. THE TWO PROJECTS THAT COMPRISE THE PROPOSED GRANT ADDRESS TWO SPECIFIC AIMS THAT ARE REPRESENTED BY THE HUMAN STUDY AND LABORATORY ANIMAL EXPERIMENT: I.E. ,1: TO ESTABLISH THE METABOLIC PROTECTIVE EFFECTS OF AN ANTI-INFLAMMATORY DIET IN OBESE, HIGH-RISK AFRICAN- AMERICAN (AA) AND EUROPEAN-AMERICAN (EA) ADULTS AND CHILDREN IN REDUCING INFLAMMATION AS INDICATED BY HOMEOSTATIC MODEL ASSESSMENT FOR INSULIN RESISTANCE (HOMA-IR), IGF-1, TUMOR NECROSIS FACTOR ALPHA (TNFA), INTERLEUKIN 6 (IL-6), AND C-REACTIVE PROTEIN (CRP), AND A CREATING MORE FAVORABLE MICROBIOME SIGNATURE; 2: TO ESTABLISH GUT MICROBES AS MEDIATORS BETWEEN ANTI-INFLAMMATORY DIETARY INPUT AND REVERSAL OF METABOLIC DYSFUNCTION AND ASSOCIATED CRC RISK. THIS COMPLEMENTS THE HUMAN STUDY BY CARRYING OUT PRE-CLINICAL MURINE MODEL STUDIES WITH SIMILAR INPUTS (DIET), INTERMEDIATE ENDPOINTS (INFLAMMATION, MICROBIOME), AND OUTCOMES (CRC-RELATED). WE HYPOTHESIZE THAT AN ANTI-INFLAMMATORY DIETARY INTERVENTION WILL REDUCE METABOLIC DYSFUNCTION AND METAINFLAMMATION THROUGH REGULATORY EFFECTS ON GUT MICROBIOTA. RESULTS FROM THIS WORK WILL ADDRESS THE ROLE OF METABOLIC DYSREGULATION IN RELATION TO FACTORS THAT ARE KNOWN TO BE IMPORTANT IN CARCINOGENESIS, THAT THEREFORE COULD HAVE PROFOUND EFFECTS ON EOCRC, HAVE IMPLICATIONS FOR OTHER OBESITY-RELATED CANCERS, AND HAVE GREAT PROMISE FOR MOVING THE FIELD FORWARD BY ADDRESSING MECHANISMS THAT DRIVE LARGE HEALTH-RELATED DISPARITIES THAT CONSISTENTLY DISFAVOR AFRICAN AMERICANS.
assistance · Last action 2026-01-22
$3,558,479
Department of Health and Human Services
HOMEOSTATIC RESET AS A NEW THERAPEUTIC PARADIGM FOR SLOW PROGRESSION DISEASES - PROJECT SUMMARY THIS PROJECT RESPONDS TO NIH DIRECTORS TRA RFA-RM-20-013 AND WILL TEST THE HYPOTHESIS THAT HOMEOSTATIC RESTORATION OF SMALL GTPASE SIGNALING TO MODIFY ALZHEIMER’S DISEASE (AD) AND AMYOTROPHIC LATERAL SCLEROSIS (ALS) PATHOGENESIS IS A GAME-CHANGING THERAPEUTIC APPROACH COMPARED TO UNIDIRECTIONAL TARGETING. IF PROVEN, THIS NEW AND INNOVATIVE PARADIGM WILL HAVE FAR-REACHING AND TRANSFORMATIVE IMPACT FOR TARGETING OTHER CHRONIC DISEASES AND DISORDERS SUCH AS AUTISM SPECTRUM DISORDER, SCHIZOPHRENIA, AND DRUG ADDICTION. THE PREDOMINANT AND CONVENTIONAL THERAPEUTIC STRATEGIES IN TREATING HUMAN DISEASES ARE UNIDIRECTIONALLY INHIBITING OR STIMULATING AFFECTED BIOLOGICAL PROCESSES. HOWEVER, IN MANY CHRONIC DISEASES SUCH AS AD AND ALS, COMPLETE INHIBITION OR ACTIVATION OF THE AFFECTED SIGNALING EVENTS MAY THEMSELVES PROMOTE DISEASES. DISEASE PROGRESSION CAN ALSO BE SPATIOTEMPORAL, WITH INITIAL ACTIVATION FOLLOWED BY INHIBITION OR VICE VERSA, AS WELL AS ACTIVATION VERSUS INHIBITION AT DIFFERENT BRAIN REGIONS. THUS, SIMPLE UNIDIRECTIONAL TARGETING MAY ITSELF BE A MAJOR REASON THAT NO DRUGS HAVE SUCCESSFULLY PREVENTED, REVERSED OR EVEN MODIFIED THE DISEASE COURSE FOR SUCH NEURODEGENERATIVE DISORDERS. TO OVERCOME THIS FORMIDABLE CHALLENGE, NEW THERAPEUTIC PARADIGMS MUST BE INVESTIGATED. ONE APPROACH IS TO RESTORE HOMEOSTATIC BALANCE INSTEAD OF COMPLETELY INHIBITING OR ACTIVATING THE AFFECTED SIGNALING PATHWAYS. THIS APPROACH IS LARGELY UNTESTED FOR AD AND ALS BUT IS BROADLY SIGNIFICANT BECAUSE MANY OTHER COMPLEX DISEASES ALSO EXHIBIT HOMEOSTATIC IMBALANCE AND SPATIOTEMPORAL DYSREGULATION OF SIGNALING PATHWAYS, MAKING THE USE OF INHIBITORS OR ACTIVATORS INEFFECTIVE IF USED INAPPROPRIATELY. THIS TRA PROJECT PROPOSES TO RESTORE THE HOMEOSTATIC BALANCE OF RHO AND RAB FAMILY SMALL GTPASE SIGNALING, WHICH IS SPATIOTEMPORALLY DYSREGULATED IN AD AND ALS. THE CLASSICAL RHO GTPASES INCLUDE RHOA, RAC1, AND CDC42, IN WHICH RHOA OFTEN ACTS IN OPPOSITION TO RAC1 AND CDC42 TO CONTROL PROTEIN PROCESSING AND TRAFFICKING AS WELL AS SYNAPTIC REMODELING. RAB GTPASES ADDITIONALLY CONTROL ER STRESS AND PROTEIN AGGREGATION. OUR PROJECT WILL APPLY INNOVATIVE DUAL FUNCTION SMALL MOLECULES TO INVESTIGATE THIS ANTAGONISM FOR RESTORING THEIR HOMEOSTATIC BALANCE. WE WILL DETERMINE THE EFFECTS OF THEIR MODULATION ON AD AND ALS HALLMARK PROTEINS AND PATHOGENESIS IN MOUSE MODELS. IF SUCCESSFUL, THIS PROJECT WILL DELIVER NOVEL FIRST-IN-CLASS DRUG LEADS, AND THE NEW THERAPEUTIC PARADIGM WILL TRANSFORM THE ENTIRE AD AND ALS DRUG DEVELOPMENT LANDSCAPE AND BEYOND. IN SUMMARY, OUR PROPOSAL PROVIDES A STRONG RATIONALE FOR THE TRANSFORMATIVE IMPACT OF ESTABLISHING HOMEOSTATIC TARGETING AT DEFECTIVE SIGNALING PROCESSES IN AD AND ALS. WITH A MULTI-INSTITUTION AND MULTI- DISCIPLINARY APPROACH, THIS PROJECT WILL LEAD TO NOVEL AND SIGNIFICANT INSIGHTS INTO WHETHER TARGETING HOMEOSTATIC BALANCES OF DEFECTIVE SIGNALING CAN MODIFY AD AND ALS DISEASE COURSE, PROVIDING A PIONEERING EXAMPLE OF APPLYING THE SAME APPROACH FOR FUTURE TARGETING OF OTHER CHRONIC AND SLOW PROGRESSION DISEASES.
assistance · Last action 2025-08-12
$3,421,894
Department of Health and Human Services
AGING SYMPTOM TRAJECTORIES IN MOTHER CARRIERS OF THE FMR1 PREMUTATION - PROJECT SUMMARY/ABSTRACT ABOUT 1 IN 151 WOMEN IN THE US ARE CARRIERS OF A GENETIC ABNORMALITY CALLED THE FMR1 PREMUTATION (FXPM). MOTHERS WHO CARRY THE FXPM ARE AT RISK FOR PASSING THE MUTATED GENE TO THEIR CHILDREN, WHICH MAY RESULT IN FRAGILE X SYNDROME. THE FXPM IS ALSO ASSOCIATED WITH SUBSTANTIALLY INCREASED RISK FOR DISEASE, INCLUDING NEURODEGENERATIVE DISEASE, PREMATURE MENOPAUSE, PSYCHIATRIC INVOLVEMENT, AND EXECUTIVE AND SOCIAL DEFICITS. NEW EVIDENCE SUGGESTS THAT FXPM CARRIER MOTHERS MAY EXPERIENCE PREMATURE AGE-RELATED DECLINE ACROSS MULTIPLE SYMPTOM DOMAINS. THE AGING EXPRESSION OF FXPM PHENOTYPE IS PARTICULARLY CONCERNING WHEN APPLIED WITHIN THE CONTEXT OF FRAGILE X FAMILIES BECAUSE THESE SYMPTOMS IMPACT NOT ONLY THE CARRIER MOTHER, BUT ALSO HER ABILITY TO CARE AND ADVOCATE FOR HER CHILDREN WITH FRAGILE X SYNDROME. HOWEVER, ALMOST ALL EVIDENCE OF AGE- RELATED DECLINE IN THIS GROUP HAS BEEN GLEANED FROM CROSS-SECTIONAL DATA THAT ARE INSUFFICIENT FOR DRAWING ROBUST LONGITUDINAL TRAJECTORIES. THIS REPRESENTS A SUBSTANTIAL BARRIER TO EFFECTIVE CLINICAL MANAGEMENT, AS WE LACK THE DATA NEEDED TO UNDERSTAND THE LONG-TERM EFFECTS OF THE FXPM GENOTYPE AND ITS IMPLICATIONS FOR FAMILIES. THIS PROPOSAL SEEKS TO DETERMINE THE STABILITY OF KEY FXPM PHENOTYPES (MENTAL HEALTH, EXECUTIVE, SOCIAL) ACROSS MIDLIFE AND EARLY OLD AGE IN FXPM CARRIER MOTHERS COMPARED TO HEALTHY CONTROLS (AIM 1); INVESTIGATE AUTONOMIC AND MOLECULAR-GENETIC FACTORS ASSOCIATED WITH AGE-RELATED SYMPTOM EXPRESSION AND THEIR INTERFACE WITH PARENTING STRESS (AIM 2); AND EVALUATE FUNCTIONAL LIMITATIONS ASSOCIATED WITH FXPM SYMPTOMS ACROSS AGE (AIM 3). WE WILL ACCOMPLISH THESE AIMS BY ADOPTING AN ACCELERATED LONGITUDINAL DESIGN TO TRACK AGE-RELATED CHANGE OCCURRING ACROSS 45-80 YEARS IN 75 FXPM CARRIER MOTHERS COMPARED TO 75 CONTROL MOTHERS. THE OVER- ARCHING GOAL IS TO INFORM THE CRITICAL AGE PERIODS AND RISK FACTORS IN AGE-RELATED DECLINE, AS WELL AS TO LAY THE GROUNDWORK FOR FUTURE MECHANISTIC STUDIES. THIS WORK IS NECESSARY TO DEVELOP STRATEGIES TO AMELIORATE FXPM SYMPTOMS, WHICH WILL IMPROVE OUTCOMES FOR BOTH FXPM CARRIER MOTHERS AND THEIR CHILDREN WITH FRAGILE X SYNDROME.
assistance · Last action 2026-03-06
$3,410,401
Department of Health and Human Services
ENSURING THE CULTURAL RELEVANCE OF DIETARY GUIDELINES DIET PATTERNS AMONG AFRICAN AMERICANS: INCREASING DIETARY QUALITY AND REDUCING TYPE 2 DIABETES RISK - PROJECT SUMMARY/ABSTRACT THE U.S. DIETARY GUIDELINES (USDG) FORM THE BASIS OF FEDERAL NUTRITION PROGRAMS AND POLICY AND PROVIDE VALUABLE GUIDANCE TO HEALTH INITIATIVES AND INDUSTRIES. THE UPDATED 2015 USDG MOVED AWAY FROM A FOCUS ON INDIVIDUAL NUTRIENTS TO A GREATER FOCUS ON DIETARY PATTERNS. THE USDG STATE THAT HEALTHY EATING GOALS CAN BE MET THROUGH A VARIETY OF DIETARY PATTERNS, BUT PRESENT HEALTHY DIET IN THREE MAIN WAYS: 1) HEALTHY U.S.- STYLE EATING PATTERN, 2) HEALTHY MEDITERRANEAN-STYLE EATING PATTERN, AND 3) HEALTHY VEGETARIAN EATING PATTERN. CURRENTLY, US ADULTS ARE FALLING SHORT OF THE NUTRITION RECOMMENDATIONS (FRUIT/VEGETABLE INTAKE, GREENS/BEANS, WHOLE GRAINS, ETC.) SET FORTH BY THE USDG AND MEASURED BY THE HEALTHY EATING INDEX (HEI). WHILE THE USDG ARE THE BASIS OF NUTRITION GUIDELINES, THE RESEARCH INFORMING THESE DIETARY PATTERN RECOMMENDATIONS HAS LARGELY BEEN DRAWN FROM OBSERVATIONAL STUDIES AMONG MOSTLY WHITE POPULATIONS. IN ADDITION, THERE HAS BEEN VERY LIMITED CULTURAL-TAILORING OF THESE DIETARY PATTERNS THAT WOULD ENSURE THAT THESE DIETS ARE ACCEPTABLE TO DIVERSE POPULATIONS, IN PARTICULAR, AFRICAN AMERICANS (AAS) LIVING IN THE SOUTH, WHO EXPERIENCE A DISPROPORTIONATE BURDEN OF CHRONIC DISEASE, ESPECIALLY TYPE 2 DIABETES (T2DM). CURRENTLY, US ADULTS ARE NOT MEETING NUTRITION RECOMMENDATIONS (FRUIT/VEGETABLE, WHOLE GRAINS, ETC.) SET FORTH BY THE USDG AND MEASURED BY THE HEALTHY EATING INDEX (HEI). FOR THIS STUDY, AA ADULT PARTICIPANTS WITH OVERWEIGHT/OBESITY AND =THREE T2DM RISK FACTORS WILL BE RECRUITED TO PARTICIPATE IN THE FOLLOWING AIMS: AIM 1: CONDUCT A 3-MONTH RANDOMIZED TRIAL AMONG AAS COMPARING ADOPTION OF THE 3 DIETARY PATTERNS [1) US, 2) MED, OR 3) VEG] USING EXISTING MATERIALS FROM THE USDG AND EXAMINE DIFFERENCES IN DIET QUALITY (HEI) AND T2DM RISK FACTORS (WEIGHT, HGBA1C). AIM 2: DRAWING ON PARTICIPANTS’ EXPERIENCES IN AIM 1, CONDUCT QUALITATIVE WORK TO REFINE AND CULTURALLY TAILOR THE DIETARY PATTERN INTERVENTION FOR AN AA AUDIENCE. AIM 3: BASED ON THE FINDINGS OF AIM 2, CONDUCT A ONE-YEAR INTERVENTION USING REVISED CULTURALLY TAILORED MATERIALS TO EXAMINE DIFFERENCES IN HEI AND T2DM RISK FACTORS AMONG PARTICIPANTS (N=198) RANDOMIZED TO ONE OF THE 3 DIETARY PATTERNS. THIS WILL RESULT IN COMMUNITY-BASED STRATEGIES AROUND PRESENTING DIETARY GUIDELINES IN A WAY TO EFFECTIVELY MEET NUTRITION RECOMMENDATIONS LEADING TO SIGNIFICANT IMPACTS ON HEALTH AMONG AA ADULTS.
assistance · Last action 2026-01-05
$3,398,571
Department of Health and Human Services
AUTONOMIC AND SENSORY DYSFUNCTIONS IN FMR1 CONDITIONS: DEVELOPMENT, MECHANISMS AND CONSEQUENCES - PROJECT SUMMARY/ABSTRACT DESPITE THE IMPAIRMENT IN FRAGILE X SYNDROME (FXS) AND THE FRAGILE X PREMUTATION (FXPM), SURPRISINGLY LITTLE RESEARCH HAS EXAMINED THE UNDERPINNINGS OF THESE IMPAIRMENTS. ONE POTENTIAL FACTOR THAT CONTRIBUTES TO IMPAIRMENT IS AUTONOMIC NERVOUS SYSTEM (ANS) DYSFUNCTION. ELEVATED PHYSIOLOGICAL AROUSAL, REFLECTING ANS DYSFUNCTION, HAS LONG BEEN IMPLICATED AS CONTRIBUTING TO LEARNING IMPAIRMENTS AND ATYPICAL BEHAVIOR IN FXS. WHILE ANS DYSFUNCTION HAS BEEN LINKED TO IMPAIRMENT IN BOTH FXS AND FXPM, RESEARCH HAS NOT EXAMINED THE PRESENCE, ONSET, DEVELOPMENTAL TRAJECTORY, OR DEVELOPMENTAL CONSEQUENCES OF ANS DYSFUNCTION OR HOW MOLECULAR-GENETIC FACTORS ARE ASSOCIATED. THIS PROJECT ADDRESSES THESE CRITICAL GAPS WITH THE FOLLOWING SPECIFIC AIMS: (1) IDENTIFY THE ONSET AND DEVELOPMENTAL TRAJECTORY OF BASELINE ANS DYSFUNCTION THROUGH PROSPECTIVE LONGITUDINAL ASSESSMENT AT 6, 9, 12, AND 24 MONTHS IN FXS (N=30 MALES) AND FXPM (N=30; 15 MALES AND 15 FEMALES) CONTRASTED TO TYPICAL CONTROLS (N=45; 30 MALES AND 15 FEMALES); (2) DETERMINE HOW MOLECULAR-GENETIC VARIATION RELATES TO THE ONSET AND/OR DEVELOPMENTAL TRAJECTORY OF ANS DYSFUNCTION IN FXS AND FXPM; (3) CHARACTERIZE BEHAVIORAL AND ANS REACTIVITY TO SENSORY STIMULI THROUGH PROSPECTIVE LONGITUDINAL ASSESSMENT AT 6, 9, 12, AND 24 MONTHS IN FXS AND FXPM; AND (4) DOCUMENT THE CONSEQUENCES OF ANS DYSFUNCTION ACROSS INFANCY ON SENSORY PROCESSING IMPAIRMENTS, ADAPTIVE SKILLS, ASD SYMPTOMS, AND SOCIAL COMMUNICATION, CONCURRENTLY AND AT 24 MONTHS IN FXS AND FXPM. THIS WORK WILL HAVE TREMENDOUS IMPACT BY GREATLY EXPANDING INFORMATION ON THE MECHANISTIC UNDERPINNINGS, BIOLOGICAL PATHWAYS, AND TIMING OF SYMPTOM PROGRESSION, WHICH IS ESSENTIAL TO IDENTIFY TARGETS AND TIMING OF TREATMENT TO REDUCE SYMPTOM SEVERITY IN FXS AND FXPM. OUR FOCUS ON INFANCY IS CRITICAL, AS EVIDENCE HAS DOCUMENTED THAT INTERVENTION PROVIDED EARLY IN LIFE HAS THE POTENTIAL TO ACCELERATE DEVELOPMENT AND IMPROVE DEVELOPMENTAL TRAJECTORIES OVER TIME IN A MULTI-DIMENSIONAL MANNER.
assistance · Last action 2026-05-11
$3,368,871
Department of the Interior
MOSTLY AT A PARK LEVEL, PROJECTS ENCOMPASS A BROAD RANGE OF RESEARCH, OPERATIONAL, ANDEDUCATIONAL ACTIVITIES ACROSS ALL ASPECTS OF CULTURAL RESOURCE STEWARDSHIP ACTIVITIES, INCLUDING BUT NOTLIMITED TO INVENTORY, MONITORING, RESEARCH, REHABILITATION, RECONSTRUCTION, RESTORATION, PRESERVATION,DOCUMENTATION, DATA RECOVERY, EDUCATION, AND CLIMATE CHANGE MITIGATION AND ADAPTATION. IN ACCORDANCE WITH THE AFRICAN AMERICAN CIVIL RIGHTS NETWORK ACT OF 20174 (PL 115-104),THE PUBLIC PURPOSE FOR THIS COOPERATIVE AGREEMENT IS TO FACILITATE FEDERAL AND NON-FEDERAL ACTIVITIES TO COMMEMORATE AND INTERPRET THE HISTORY OF THE AFRICAN AMERICAN CIVIL RIGHTS MOVEMENT THE SIGNIFICANCE OF THE CIVIL RIGHTS MOVEMENT AS A CRUCIAL ELEMENT IN THE EVOLUTION OF THE CIVIL RIGHTS ACT OF 1946 AND THE RELEVANCE OF THE AFRICAN AMERICAN CIVIL RIGHTS MOVEMENT IN FOSTERING THE SPIRIT OF SOCIAL JUSTICE AND NATIONAL RECONCILIATION FOR THE EDUCATION OF THE GENERAL PUBLIC. THE PROJECT SEEKS TO ADVANCE SCHOLARSHIP AND SERVE AS A NATIONAL MODEL FOR STIMULATING INTERDISCIPLINARY WORK IN CIVIL RIGHTS RESEARCH, EDUCATION, PROGRAMMING AND ADVOCACY THROUGH VALUABLE CIVIL RIGHTS-ERA COLLECTIONS, PUBLIC OPPORTUNITIES FOR ENGAGEMENT AND INFORMATION PERTINENT TO PUBLIC-POLICY DISCUSSIONS AROUND SOCIAL JUSTICE ISSUES. BENEFICIARIES INCLUDE STATE AND LOCAL GOVERNMENTS, FEDERALLY RECOGNIZED INDIAN TRIBAL GOVERNMENTS, NONPROFIT ORGANIZATIONS, EDUCATIONAL OR SCIENTIFIC INSTITUTIONS, ASSOCIATIONS, INDIVIDUALS.
assistance · Last action 2024-09-19
$3,362,100
Department of the Interior
MOSTLY AT A PARK LEVEL, PROJECTS ENCOMPASS A BROAD RANGE OF RESEARCH, OPERATIONAL, AND EDUCATIONAL ACTIVITIES ACROSS ALL ASPECTS OF CULTURAL RESOURCE STEWARDSHIP ACTIVITIES, INCLUDING BUT NOT LIMITED TO INVENTORY, MONITORING, RESEARCH, REHABILITATION, RECONSTRUCTION, RESTORATION, PRESERVATION, DOCUMENTATION, DATA RECOVERY, EDUCATION, AND CLIMATE CHANGE MITIGATION AND ADAPTATION. THIS PROJECT WILL DEVELOP A STRATEGIC PLANNING AND IMPLEMENTATION PROCESS FOR THE CENTER FOR CIVIL RIGHTS HISTORY AND RESEARCH (CRC) AT THE UNIVERSITY OF SOUTH CAROLINA. THIS CONSULTATION WILL GUIDE THE CENTER IN THE EXPANSION OF ITS STAFF CAPACITY AND PROGRAMMATIC INITIATIVES TO RESEARCH, PRESERVE CULTURAL RESOURCES, INTERPRET, AND ENGAGE THE PUBLIC IN AFRICAN AMERICAN CIVIL RIGHTS HISTORY. BENEFICIARIES INCLUDE STATE AND LOCAL GOVERNMENTS, FEDERALLY RECOGNIZED INDIAN TRIBAL GOVERNMENTS, NONPROFIT ORGANIZATIONS, EDUCATIONAL OR SCIENTIFIC INSTITUTIONS, ASSOCIATIONS, INDIVIDUALS.
assistance · Last action 2023-08-23
$3,362,100
Department of the Interior
PROJECT FUNDING WILL SUPPORT THE EXHIBIT - JUSTICE FOR ALL- SOUTH CAROLINA AND THE AMERICAN CIVIL RIGHTS MOVEMENT, COORDINATION AND ASSISTANCE WITH SOUTH CAROLINA AFRICAN AMERICAN CIVIL RIGHTS NETWORK AND PROVIDE RESOURCES FOR OTHER NETWORK SITES AND INSTITUTIONS, CIVIL RIGHTS RESEARCH EFFORTS, ESTABLISH A LECTURE SERIES ON WOMEN IN THE MOVEMENT, AND ESTABLISH A RECURRING CIVIL RIGHTS HISTORY CONFERENCE.TRANSFER OF KNOWLEDGE ELEMENTS FOR THE PROJECT WILL INCLUDE THE ESTABLISHMENT OF A LECTURE SERIES ON WOMEN IN THE MOVEMENT AND A RECURRING INTERDISCIPLINARY, CIVIL RIGHTS HISTORY CONFERENCE IN COLLABORATION WITH THE NPS. A SCHOLARLY PRESENTATION WILL BE CONDUCTED IN CONJUNCTION WITH NPS TO SHARE WITH ALL INTERESTED NPS UNITS AND STAFF THE RESULTS OF THIS PROJECT YEARLY.
assistance · Last action 2022-06-23
$3,362,100
Department of Education
CAROLINA FAMILY ENGAGEMENT CENTER (CFEC)
assistance · Last action 2025-09-23
$3,323,289
Department of Energy
DESIGN OF NEW CATALYSTS FOR THE GENERATION OF CLEAN H2 FROM LIQUID ORGANIC HYDROGEN CARRIERS: DEHYDROGENATION OF METHYLCYCLOHEXANE ON BIMETALLIC CATALYSTS
assistance · Last action 2025-08-18
$3,181,725
Department of Health and Human Services
HOSPITAL QUALITY, MEDICAID EXPANSION, AND RACIAL/ETHNIC DISPARITIES IN MATERNAL MORTALITY AND MORBIDITY
assistance · Last action 2024-06-23
$3,165,509
Department of Health and Human Services
LINKING EXERCISE FOR ADVANCING DAILY STRESS (LEADS) MANAGEMENT AND RESILIENCE IN BLACK FAMILIES - PROJECT SUMMARY/ABSTRACT CHRONIC STRESSORS, SUCH AS RACIAL DISCRIMINATION, HAVE WIDE-REACHING HARMFUL EFFECTS ON THE PHYSICAL, SOCIAL, AND PSYCHOLOGICAL WELL-BEING OF MANY AFRICAN AMERICAN (AA) FAMILIES. THESE STRESSORS PLACE SOME AA ADOLESCENTS, WHO ALREADY EXPERIENCE LOW RATES OF PHYSICAL ACTIVITY (PA) AND HIGH RATES OF OBESITY, AT EVEN GREATER RISK FOR DEVELOPING CHRONIC DISEASES. PREVIOUS FAMILY-BASED INTERVENTIONS HAVE TARGETED PA, DIET, AND SEDENTARY BEHAVIORS TO PREVENT AND MANAGE OVERWEIGHT AND OBESITY, BUT FEW HAVE BEEN SUCCESSFUL FOR AA ADOLESCENTS. WE PROPOSE THAT THIS MAY BE BECAUSE RACIAL STRESSORS, SUCH AS RACIAL DISCRIMINATION, ARE A MAJOR BARRIER TO ENGAGEMENT IN HEALTH PROMOTION EFFORTS, WHICH HAS BEEN SIGNIFICANTLY OVERLOOKED IN PREVIOUS INTERVENTIONS FOR AA FAMILIES. RESILIENCE-BASED INTERVENTIONS THAT EMPOWER YOUTH AGAINST THE DELETERIOUS EFFECTS OF RACIAL DISCRIMINATION HAVE SHOWN IMPROVEMENTS ACROSS A BROAD RANGE OF OUTCOMES INCLUDING MENTAL HEALTH, ACADEMIC ACHIEVEMENT, AND RISK-TAKING BEHAVIORS. HOWEVER, NO PREVIOUS STUDY HAS EVALUATED A FAMILY RESILIENCE AND CULTURAL ASSETS APPROACH FOR INCREASING ENGAGEMENT IN PA IN AA FAMILIES. THE LINKING EXERCISE FOR ADVANCING DAILY STRESS (LEADS) MANAGEMENT AND RESILIENCE INTERVENTION INTEGRATES A CULTURAL STRENGTH-BASED INTERVENTION TO ADDRESS RACIAL DISCRIMINATION AND RELATED STRESSORS TO PROMOTE BEHAVIORAL SKILLS FOR INCREASING PA IN OVERWEIGHT AA ADOLESCENTS AND THEIR PARENTS. BASED ON MURRY’S MODEL, FAMILY SYSTEMS, AND SOCIAL COGNITIVE THEORIES, THE PROPOSED INTERVENTION INTEGRATES COMPONENTS THAT FOSTER ETHNIC-RACIAL IDENTITY (MEANING AND VALUE OF RACIAL GROUP IDENTITY), ETHNIC-RACIAL SOCIALIZATION (COMMUNICATION ABOUT POSITIVE AND NEGATIVE RACIALIZED EXPERIENCES), CULTURAL ASSETS (SPIRITUALITY, CULTURAL TRADITIONS), AND FAMILY RESILIENCE (PARENT SUPPORT, POSITIVE PARENTING, FAMILY ROUTINES). WE PROPOSE THAT THESE PROTECTIVE FACTORS AS INTEGRATED INTO THE LEADS INTERVENTION WILL BUFFER THE NEGATIVE EFFECTS OF RACIAL STRESSORS, ESPECIALLY FOR THOSE WHO HAVE GREATER (VS. LOWER) PERCEIVED RACIAL DISCRIMINATION AT BASELINE, WHICH WILL LEAD TO GREATER IMPROVEMENTS IN PA. THIS APPROACH RECOGNIZES THE CONSIDERABLE HETEROGENEITY THAT EXISTS AMONG AA FAMILIES IN TERMS OF EXPERIENCES WITH RACIAL DISCRIMINATION AS A MODERATE VARIABLE. OUR PILOT RESEARCH INDICATES THAT THE LEADS FAMILY-BASED RESILIENCE INTERVENTION WAS FEASIBLE AND ACCEPTABLE AND LED TO INCREASED MODERATE-TO-VIGOROUS PA (MVPA) FOR ADOLESCENTS. THUS, THE PRIMARY AIM OF THIS STUDY IS 1) TO EVALUATE THE EFFICACY OF THE LEADS INTERVENTION AND MODERATION EFFECTS OF PERCEIVED RACIAL DISCRIMINATION ON INCREASING MVPA FROM BASELINE TO POST-INTERVENTION, AND MAINTENANCE AT A 6-MONTH FOLLOW-UP IN OVERWEIGHT AA ADOLESCENTS. SECONDARY AIMS WILL EXAMINE 2) THE EFFECT OF THE LEADS INTERVENTION AND MODERATING EFFECTS OF RACIAL DISCRIMINATION ON LIGHT PA, DIETARY INTAKE, FAMILY MEALTIME, BODY MASS INDEX, WAIST CIRCUMFERENCE, AND BLOOD PRESSURE OUTCOMES, 3) THE EFFECTS OF THE INTERVENTION AND MODERATING EFFECTS ON PARENT OUTCOMES, AS WELL AS EXAMINING 4) MEDIATORS OF THE INTERVENTION EFFECT ON CHANGES IN PA.
assistance · Last action 2025-08-15
$3,160,277
Department of Health and Human Services
PHYSICAL ACTIVITY AND WEIGHT LOSS TO IMPROVE FUNCTION AND PAIN AFTER TOTAL KNEE REPLACEMENT - TOTAL KNEE REPLACEMENT (TKR) UTILIZATION CONTINUES TO INCREASE, PLACING SUBSTANTIAL BURDEN ON THE ECONOMY. AS PATIENTS LIVE LONGER WITH TKR, IT IS ESSENTIAL TO IDENTIFY STRATEGIES THAT WILL MAXIMIZE LONG-TERM FUNCTIONAL OUTCOMES AND PROMOTE HEALTH-RELATED QUALITY OF LIFE AND INDEPENDENCE AS ADULTS AGE AFTER SURGERY. THE MAJORITY OF TKR PATIENTS MEET CRITERIA FOR OVERWEIGHT/OBESITY AND REMAIN PHYSICALLY INACTIVE AFTER SURGERY, BOTH OF WHICH HEIGHTEN THE RISK OF POOR FUNCTIONAL OUTCOMES AND DISABILITY. FURTHER, MOST PATIENTS WILL ACTUALLY GAIN WEIGHT WITHIN TWO YEARS AFTER SURGERY. PATIENTS AFTER TKR ARE ALSO AT AN INCREASED RISK OF DEATH FROM CARDIOVASCULAR AND MENTAL DISEASES. PROMOTING WEIGHT MANAGEMENT MAY BE AN EFFECTIVE STRATEGY TO IMPROVE LONG-TERM FUNCTIONAL AND PHYSICAL ACTIVITY OUTCOMES AFTER TKR, REDUCE THE RISK OF DISABILITY AND DEATH FROM CARDIOVASCULAR AND MENTAL DISEASES, AND IMPROVE THE VALUE OF THE COSTLY SURGERY. WE PROPOSE TO EXAMINE THE EFFECTIVENESS OF A PATIENT-CENTERED (PACE) WEIGHT LOSS PROGRAM IN ADULTS AFTER TKR IN A FULLY-POWERED, TWO-ARM RANDOMIZED CONTROLLED TRIAL. PATIENTS (N=250) WILL BE RANDOMIZED TO RECEIVE EITHER (1) PACE WEIGHT LOSS PROGRAM OR (2) CHRONIC DISEASE SELF-MANAGEMENT (CDSM) CONTROL GROUP. PACE PARTICIPANTS WILL START THE PATIENT-CENTERED PROGRAM 12 WEEKS AFTER TKR AND CONTINUE FOR 12 MONTHS. PACE IS TAILORED TO THE PATIENTS’ NEEDS AND UNIQUE BARRIERS TO DIET AND PHYSICAL ACTIVITY. PACE FOCUSES ON REDUCING CALORIC INTAKE AND INCREASING PHYSICAL ACTIVITY (AEROBIC AND RESISTANCE) TO FACILITATE A WEIGHT LOSS OF AT LEAST 7% OF INITIAL BODY WEIGHT. COACHING CALLS WITH A TRAINED BEHAVIORAL INTERVENTIONIST WILL OCCUR WEEKLY DURING MONTHS 1-4, BIWEEKLY DURING MONTHS 5-6, AND MONTHLY DURING MONTHS 7-12. NO COACHING WILL OCCUR DURING THE MAINTENANCE PHASE (MONTHS 13-18). CDSM WILL RECEIVE A SELF-DIRECTED VERSION OF THE PROGRAM AND MONTHLY CALLS ON TOPICS NOT RELATED TO STUDY OUTCOMES. DATA COLLECTION WILL OCCUR AT BASELINE (12 WEEKS AFTER SURGERY), 6 MONTHS (END OF INTENSIVE INTERVENTION), 12 MONTHS (END OF TREATMENT), AND 18 MONTHS (MAINTENANCE). ASSESSMENTS WILL INCLUDE MEASURES OF WEIGHT, SECONDARY OUTCOMES (E.G., PHYSICAL ACTIVITY, PAIN, FUNCTION), AND POTENTIAL MEDIATORS FROM OUR CONCEPTUAL MODEL (E.G., ADHERENCE, SELF-EFFICACY, AUTONOMY, COMPETENCE). DATA RELATED TO THE COST OF IMPLEMENTING THE PACE WEIGHT LOSS INTERVENTION RELATIVE TO CONTROL WILL ALSO BE COLLECTED TO EXAMINE THE COST-EFFECTIVENESS OF REDUCING WEIGHT ON PATIENT OUTCOMES. THE PRIMARY OUTCOME IS WEIGHT CHANGE AT 6 MONTHS. THE EXPECTED OUTCOME FROM THIS STUDY IS TO DETERMINE THE EFFECTIVENESS AND LONG-TERM MAINTENANCE OF A REFINED PATIENT-CENTERED WEIGHT LOSS PROGRAM TAILORED SPECIFICALLY FOR ADULTS AFTER TKR. IF PACE IS EFFECTIVE AT IMPROVING SHORT- AND LONG-TERM OUTCOMES, AND IS FOUND TO BE COST-EFFECTIVE, ORTHOPEDIC CENTERS AND/OR INSURANCE COMPANIES COULD CONSIDER OFFERING THIS PROGRAM TO TKR PATIENTS, OFFERING SIGNIFICANT BENEFITS TO THE RISING NUMBER OF ADULTS UNDERDOING TKR.
assistance · Last action 2026-04-28
$3,144,626
Department of Commerce
THE CENTRALIZED DATA MANAGEMENT OFFICE (CDMO) IS MAINTAINED IN SUPPORT OF THE SYSTEM-WIDE MONITORING PROGRAM AND RELATED NERRS ACTIVITIES. THE PURPOSE OF THE CDMO, HOUSED AT THE UNIVERSITY OF SOUTH CAROLINA, IS TO MANAGE THE BASIC INFRASTRUCTURE AND DATA PROTOCOL TO SUPPORT THE COLLECTION, ASSIMILATION AND EXCHANGE OF HIGH QUALITY DATA, METADATA, AND INFORMATION WITHIN THE FRAMEWORK OF NERRS SITES, STATE COASTAL ZONE MANAGEMENT (CZM) PROGRAMS AND NOAA OCM, AS WELL AS OTHER STATE AND FEDERALLY-FUNDED EDUCATION, MONITORING AND RESEARCH PROGRAMS. THIS PROPOSAL REQUESTS: CONTINUED FUNDING TO SUPPORT THE CDMO IN PROMOTING AND PROVIDING LONG-TERM DATABASE AND INFORMATION MANAGEMENT, AS WELL AS FACILITATING INTERACTION WITHIN AND AMONG NERRS SITES, ASSOCIATED PROJECTS AND PROGRAMS, CZM PROGRAMS, AND OTHER USERS OF THE DATA AND DERIVED INFORMATION. PRIMARY FOCI WILL BE DATA AND INFORMATION MANAGEMENT AND TECHNICAL SUPPORT FOR SWMP TO INCREASE THE AWARENESS OF NERRS' GOALS AND ACTIVITIE
assistance · Last action 2024-09-17
$3,076,550
National Aeronautics and Space Administration
SINGLE SOURCE PARTICIPATION IN THE NASA HIGH-RATE COMPOSITES AIRCRAFT MANUFACTURING (HICAM) PROJECT PHASE 1 PERFORMING WORK APPROVED BY NASA AND THE ADVANCED COMPOSITES CONSORTIUM. P1.TPC.IMP THERMOPLASTIC -INTEGRATED MASTER SCHEDULE & PLAN DEVEL
assistance · Last action 2026-03-26
$3,012,620
Department of Health and Human Services
COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION
assistance · Last action 2024-12-19
$3,010,000
Department of Health and Human Services
ECO-EVOLUTIONARY DYNAMICS OF ESCHERICHIA COLI IN AN ISLAND SYSTEM: ENVIRONMENTAL DRIVERS OF WATERBORNE URINARY TRACT INFECTIONS - PROJECT SUMMARY: WATER MAY BE AN UNDERRECOGNIZED BUT IMPORTANT ROUTE OF UROPATHOGEN TRANSMISSION CAUSING URINARY TRACT INFECTIONS (UTLS). THIS REALIZATION IS SUPPORTED BY RECENT REPORTS OF THE PRESENCE OF UROPATHOGENS IN WATER SUPPLIES FROM MULTIPLE COUNTRIES, AND OUR REPORT OF A DECREASE IN UTLS FOLLOWING INSTALLATION OF A NEW WATER TREATMENT PLANT ON SAN CRISTOBAL ISLAND IN GALAPAGOS, ECUADOR. DRINKING OR BATHING IN CONTAMINATED WATER MAY EXPOSE PEOPLE TO EXTRAINTESTINAL INFECTIONS CAUSED BY ESCHERICHIA COLI, THE MOST COMMON PATHOGEN ASSOCIATED WITH UTLS. STUDIES ARE NEEDED TO INVESTIGATE UROPATHOGENIC E. COLI IN DRINKING WATER SYSTEMS AND LINKS TO INFECTIOUS DISEASE. THE HYPOTHESIS FOR THIS WORK IS THAT WATERBORNE EXPOSURES TO E. COLI ARE A CAUSATIVE AGENT OF COMMUNITY-ACQUIRED UTLS, DRIVEN BY ENVIRONMENTAL FACTORS AND HOUSEHOLD WATER USE. THIS HYPOTHESIS WILL BE TESTED IN THREE SPECIFIC AIMS: (1) MODEL THE DRIVERS AND DYNAMICS OF WATER SYSTEM E.COLI CONTAMINATION, (2) IDENTIFY SOCIO-BEHAVIORAL, EPIDEMIOLOGICAL, GENOMIC, AND ECOLOGICAL FACTORS ASSOCIATED WITH E. COLI UTLS AND EVALUATE WATER AS A TRANSMISSION SOURCE, AND (3) ESTIMATE THE IMPACT OF MODELED WATERBORNE E. COLI EXPOSURES AT POINTS OF USE ON UTI RISK. RESULTS FROM THIS WORK HAVE THE POTENTIAL TO REVOLUTIONIZE OUR UNDERSTANDING OF THE ETIOLOGY OF UTLS AND THE ECOLOGY OF UROPATHOGENIC E. COLI. MODELS WILL ALSO INFORM INTERVENTIONS TO IMPROVE WATER QUALITY AND PREVENT DISEASE.
assistance · Last action 2025-09-16
$3,000,004
Department of Education
UPWARD BOUND UNIVERSITY OF SOUTH CAROLINA COLUMBIA CAMPUS
assistance · Last action 2026-05-19
$2,999,935
Department of Health and Human Services
VALIDITY AND UTILITY OF CONSUMER-BASED WEARABLE FITNESS TRACKERS TO MONITOR FREE-LIVING PHYSICAL ACTIVITY ENERGY EXPENDITURE AND SLEEP IN CHILDREN 5-12 YEARS OLD - ACCURATE MEASUREMENT OF FREE-LIVING PHYSICAL ACTIVITY (PA), ENERGY EXPENDITURE (EE), AND SLEEP OF CHILDREN (5-12YRS) IS COMPLEX, WITH NO SINGLE METHOD FREE OF LIMITATIONS. VALIDATION STUDIES OF PA, EE, AND SLEEP HAVE DEMONSTRATED THAT COMBINING HR AND ACCELEROMETRY DATA (E.G., STEPS, COUNTS, RAW SIGNAL) PROVIDES THE MOST ACCURATE ESTIMATE OF PA, EE, AND SLEEP. UNFORTUNATELY, THE SIMULTANEOUS COLLECTION OF HR AND ACCELEROMETRY OVER ROUTINE MONITORING TIMEFRAMES (E.G., 7 DAYS) HAS BEEN LIMITED BECAUSE HISTORICALLY MEASURING HR HAS RELIED ON UNCOMFORTABLE CHEST STRAP TELEMETRY. ADVANCEMENTS IN WEARABLE TECHNOLOGY HAVE ELIMINATED THIS ISSUE BY INCORPORATING THE NONINVASIVE ASSESSMENT OF HR VIA PHOTOPLETHYSMOGRAPHY IN WIDELY-AVAILABLE CONSUMER WEARABLE DEVICES (E.G., FITBITS, GARMIN) THAT ALSO INCLUDE ACCELEROMETRY. STUDIES HAVE SHOWN THAT HR ESTIMATES FROM CONSUMER WEARABLES ARE COMPARABLE TO THOSE COLLECTED VIA ECG OR CHEST STRAP TELEMETRY. HOWEVER, VALIDATION STUDIES OF CONSUMER WEARABLES HAVE FOCUSED ALMOST EXCLUSIVELY ON PROPRIETARY ACTIVITY OUTPUT (E.G., STEPS) AND HAVE MOSTLY BEEN CONDUCTED ON HEALTHY ADULTS, OLDER ADULTS, OR CLINICAL POPULATIONS (E.G., PEOPLE WITH NEUROMUSCULAR OR GAIT ABNORMALITIES). CONSUMER WEARABLES HOLD PROMISE FOR COLLECTING PA, EE, AND SLEEP DATA WITH CHILDREN 5 TO 12YRS, YET NO STUDIES HAVE BEEN CONDUCTED TO ESTABLISH THEIR VALIDITY AND UTILITY/FEASIBILITY IN THIS POPULATION. THE OBJECTIVES OF THE PROPOSED PROJECT ARE TO CONDUCT A SERIES OF STUDIES THAT INCLUDE BOTH LABORATORY AND FIELD-BASED PROTOCOLS TO EVALUATE THE RELIABILITY, VALIDITY AND UTILITY/FEASIBILITY OF CONSUMER WEARABLES FOR MEASURING CHILDREN’S PA, EE, AND SLEEP IN FREE-LIVING CONDITIONS. WE WILL EVALUATE THE DIFFERENT FEATURES OF THE DEVICES (E.G., PA, HR) IN THE LAB AND IN REAL-WORLD CONDITIONS. IN ADDITION, WE WILL EVALUATE THE UTILITY/FEASIBILITY OF CONSUMER WEARABLES FOR MULTI-DAY WEAR COMPLIANCE. WE WILL ACCOMPLISH THE FOLLOWING AIMS. AIM 1. DEVELOP AND VALIDATE OPEN- SOURCE EQUATIONS TO ESTIMATE PAEE AND TIME SPENT PHYSICALLY ACTIVE USING THE ACTIVITY AND HR DATA FROM CONSUMER WEARABLES COMPARED TO THE PAEE OUTPUT FROM THE CONSUMER WEARABLES’ PROPRIETARY PROCESSING ALGORITHMS AND A CRITERION MEASURE OF PAEE (I.E., INDIRECT CALORIMETRY). AIM 2. DEVELOP AND VALIDATE OPEN-SOURCE EQUATIONS TO ESTIMATE TOTAL SLEEP TIME, SLEEP EFFICIENCY, AND TIMING FROM CONSUMER WEARABLES USING THEIR ACTIVITY AND HR DATA COMPARED TO THE SLEEP OUTPUT FROM THE CONSUMER WEARABLES’ PROPRIETARY PROCESSING ALGORITHMS AND A CRITERION MEASURE OF SLEEP (I.E., PSG AND ACTIGRAPHY). AIM 3. EVALUATE THE VALIDITY OF THE PAEE AND SLEEP EQUATION ESTIMATES FROM THE ALGORITHMS CREATED IN AIM 1 & 2 AGAINST A CRITERION (I.E., ACTIHEART) UNDER FREE-LIVING CONDITIONS. THIS PROJECT IS SIGNIFICANT BECAUSE IT WILL BE AMONG THE FIRST TO ESTABLISH THE VALIDITY OF CONSUMER WEARABLES FOR PAEE AND SLEEP MONITORING OF CHILDREN. THIS PROJECT IS INNOVATIVE AS IT WILL USE ADVANCED STATISTICAL MODELING TECHNIQUES, INCLUDING MACHINE LEARNING, TO SYSTEMATICALLY TEST THE VALIDITY AND UTILITY/FEASIBILITY OF CONSUMER WEARABLES FOR CHILDREN. OUR VISION IS TO LEVERAGE THE BIOMETRIC DATA COLLECTED ACROSS CONSUMER WEARABLES TO PRODUCE ESTIMATES OF PAEE AND SLEEP IN CHILDREN. THIS WILL ALLOW PRACTITIONERS AND RESEARCHERS ALIKE TO MORE ACCURATELY MEASURE 24-HOUR MOVEMENT BEHAVIORS IN CHILDREN.
assistance · Last action 2025-12-30
$2,994,657
Department of Defense
AUTOMATED INTERVIEW DEVELOPMENT
contract · Last action 2025-05-20
$2,990,853
Department of Health and Human Services
EVALUATION OF CIGARETTE PACKAGE INSERTS FOR ENHANCED COMMUNICATION WITH SMOKERS
assistance · Last action 2026-04-30
$2,901,312
Department of Energy
IN SUPPORT OF THE CULTURAL RESOURCE MANAGEMENT WHICH INCLUDES IDENTIFICATION, EVALUATION AND PROTECTIONS OF ARCHAEOLOGICAL AND HISTORICAL SITES AND THE COLLECTION, ANALYSIS, AND PRESERVATION OF ARTIFACTS AND MAINTENANCE OF THE CURATION FACILITY.
assistance · Last action 2026-03-30
$2,889,476
Department of Health and Human Services
ONSET, DEVELOPMENT, AND CONSEQUENCES OF AUTONOMIC AND SENSORY DYSFUNCTION IN AUTISM SPECTRUM DISORDER - PROJECT SUMMARY/ABSTRACT ATYPICAL SENSORY REACTIVITY IS PERVASIVE AND HIGHLY IMPAIRING IN AUTISM SPECTRUM DISORDER (ASD). SENSORY REACTIVITY CONTRIBUTES TO CORE AND ASSOCIATED ASD FEATURES, SUCH AS IMPAIRED SOCIAL COMMUNICATION AND ELEVATED SOCIAL FEAR, WHICH ARE EVIDENT IN INFANCY AND PREDICTIVE OF LATER ANXIETY. INCREASING THEORETICAL AND EMPIRICAL DATA SUGGEST THAT INDIVIDUALS WITH ASD MAY EXHIBIT AUTONOMIC NERVOUS SYSTEM (ANS) HYPERAROUSAL AT BASELINE (I.E., AT REST), IMPLYING AN ELEVATED BIOLOGICAL STATE PRIMED FOR THREAT EVEN DURING NON-THREATENING SITUATIONS. WHILE ANS DYSFUNCTION HAS BEEN POSITED AS AN UNDERLYING NEUROBIOLOGICAL MECHANISM CONTRIBUTING TO SPECIFIC FEATURES OF THE ASD PHENOTYPE, RESEARCH HAS NOT EXAMINED THE PRESENCE, ONSET, DEVELOPMENTAL TRAJECTORY, OR DEVELOPMENTAL CONSEQUENCES OF ANS FUNCTION IN INFANTS AT AN ELEVATED LIKELIHOOD OF ASD. THUS, THIS STUDY PROPOSES A LONGITUDINAL STUDY OF ANS FUNCTION WITH DATA COLLECTED AT 6, 9, 12, 24, AND 36 MONTHS IN INFANTS AT ELEVATED LIKELIHOOD FOR ASD GIVEN AN OLDER SIBLING DIAGNOSED WITH ASD (EL-ASIBS) IN COMPARISON TO LOW-LIKELIHOOD INFANTS TO INVESTIGATE ANS DYSFUNCTION AS A POTENTIAL MECHANISM OF HETEROGENEITY IN CORE AND ASSOCIATED FEATURES OF ASD, INCLUDING SENSORY PROCESSING, SOCIAL COMMUNICATION, AND SOCIAL FEAR. THE SPECIFIC AIMS ARE TO (1) IDENTIFY THE PRESENCE, ONSET, AND DEVELOPMENTAL TRAJECTORY OF BASELINE ANS DYSFUNCTION; (2) DETERMINE THE DEVELOPMENTAL TRAJECTORY OF ANS RESPONSIVITY TO SENSORY INPUT AND ITS RELATIONSHIP TO BASELINE ANS (DYS)FUNCTION; AND (3) IDENTIFY HOW BASELINE ANS DYSFUNCTION AND RESPONSIVITY TO SENSORY INPUT PREDICT SOCIAL COMMUNICATION AND SOCIAL FEAR ACROSS INFANCY. THIS WORK WILL HAVE TREMENDOUS IMPACT BY INCREASING OUR UNDERSTANDING OF THE NEUROBIOLOGICAL MECHANISTIC UNDERPINNINGS AND BIOLOGICAL PATHWAYS LEADING TO ASD SYMPTOM PROGRESSION THAT IS ESSENTIAL TO IDENTIFY TARGETS AND TIMING OF TREATMENT FOR ASD.
assistance · Last action 2026-05-14
$2,831,480
National Science Foundation
SUPPORTING RURAL STEM MIDDLE SCHOOL TEACHERS AND CAREER COUNSELORS IN THE DEVELOPMENT OF EFFECTIVE STEM CONTENT AND CAREER DEVELOPMENT EXPERIENCES -RURAL YOUTH, IN PARTICULAR, HAVE LIMITED OPPORTUNITIES TO GAIN EXPOSURE, DEVELOP INTERESTS, AND BROADEN PARTICIPATION IN THE STEM WORKFORCE. WHILE SCHOOL COUNSELORS MAY HAVE EXTENSIVE TRAINING IN CAREER DEVELOPMENT, STEM TEACHERS FACE MANY CHALLENGES EFFECTIVELY INFUSING CAREER DEVELOPMENT INTO THEIR INSTRUCTION. THIS PROJECT WILL PROVIDE RURAL STEM MIDDLE SCHOOL TEACHERS AND CAREER COUNSELORS PROFESSIONAL DEVELOPMENT AND THE SUPPORT NEEDED TO COLLABORATE WITH EACH OTHER AND LOCAL COMMUNITY ASSETS IN DESIGNING, INTEGRATING, AND IMPLEMENTING EFFECTIVE STEM CONTENT AND CAREER DEVELOPMENT ACTIVITIES. LOCAL TEAMS WILL CO-DEVELOP PROJECT-BASED LEARNING UNITS THAT INCORPORATE A PLACE-BASED EDUCATION PERSPECTIVE INVOLVING STEM ASSETS, CAREERS, AND STAKEHOLDERS FROM THE LOCAL COMMUNITIES FOR MIDDLE SCHOOL RURAL YOUTH THAT INTENTIONALLY INFUSE STEM CAREERS IN THEIR AREA WITH STEM CONTENT. RESEARCH AIMS OF THE STUDY SEEK TO EXPLORE THE SENSE OF JOB SATISFACTION, ISOLATION, AND IMPACT TO STEM PRACTICE EXPERIENCED BY RURAL TEACHERS AND COUNSELORS AS A RESULT OF THEIR COLLABORATION IN THIS PROFESSIONAL DEVELOPMENT MODEL AS WELL AS STUDENT STEM-RELEVANT MOTIVATION, SELF-EFFICACY, AND LEARNING AFTER PARTICIPATING IN THE UNITS. THIS PROJECT WILL EXAMINE THE FEASIBILITY, ACCEPTABILITY, AND APPROPRIATENESS OF A COLLABORATIVE TEACHER DEVELOPMENT MODEL ON BOTH TEACHER AND CAREER COUNSELOR CAREER DEVELOPMENT, AS WELL AS STUDENT OUTCOMES. SIXTY MIDDLE SCHOOL TEACHERS AND 30 SCHOOL COUNSELORS FROM 16 RURAL SCHOOLS THAT SERVE OVER 6,000 STUDENTS WILL PARTICIPATE IN AN INTENSIVE, MULTI-FACETED, PROFESSIONAL DEVELOPMENT EXPERIENCE INVOLVING COLLABORATION AND CURRICULAR DEVELOPMENT. RESEARCHERS WILL USE SURVEYS, INTERVIEWS, AND FOCUS GROUPS TO EXAMINE THE IMPACT OF THEIR COLLABORATION EXPERIENCES ON TEACHER AND CAREER COUNSELOR PROFESSIONAL DEVELOPMENT AND PRACTICE. STUDENT OUTCOMES WILL INCLUDE TEACHER ASSESSMENTS OF STUDENTS' DEEPER LEARNING (I.E., CREATIVITY, INNOVATION, CRITICAL THINKING), THE IMPACT OF COLLABORATION, AND STUDENTS' SELF-REPORTS OF THEIR STEM MOTIVATION, STEM CAREER INTERESTS, AND SELF-EFFICACY. IN ADDITION TO IMPACTS ON MIDDLE SCHOOL STUDENT INTEREST IN STEM CAREERS, THE FORMAL EVALUATION OF THE CORE MODEL WILL ALLOW THE RESEARCH TEAM TO DEVELOP INFORMATION ON PROMISING PROCESSES FOR INCLUSIVE DESIGN. EXAMPLES OF THE LEARNING EXPERIENCES DEEMED TO BE OF HIGH IMPACT IN THE CONTEXTS IN WHICH THE PROJECTS ARE TO BE CARRIED OUT, ENABLING OTHERS TO SUCCESSFULLY IMPLEMENT PLACE-BASED CAREER INFUSED AUTHENTIC STEM PROBLEM-BASED LEARNING ACROSS DIVERSE CONTEXTS. THE DISCOVERY RESEARCH PREK-12 PROGRAM (DRK-12) SEEKS TO SIGNIFICANTLY ENHANCE THE LEARNING AND TEACHING OF SCIENCE, TECHNOLOGY, ENGINEERING AND MATHEMATICS (STEM) BY PREK-12 STUDENTS AND TEACHERS, THROUGH RESEARCH AND DEVELOPMENT OF INNOVATIVE RESOURCES, MODELS AND TOOLS. PROJECTS IN THE DRK-12 PROGRAM BUILD ON FUNDAMENTAL RESEARCH IN STEM EDUCATION AND PRIOR RESEARCH AND DEVELOPMENT EFFORTS THAT PROVIDE THEORETICAL AND EMPIRICAL JUSTIFICATION FOR PROPOSED PROJECTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
assistance · Last action 2025-08-29
$2,817,700

Federal contract dollars to this establishment. Primary NAICS: 541715 - RESEARCH AND DEVELOPMENT IN THE PHYSICAL, ENGINEERING, AND LIFE SCIENCES (EXCEPT NANOTECHNOLOGY AND BIOTECHNOLOGY). Last action: 2026-07-01. Source: USAspending.gov, net obligations. Recipient address is the SAM registration / HQ address, not necessarily the worksite.

Inspection history

Date	Trigger	Violations	Serious	Penalty
2026-01-05	Fatality/Catastrophe	0	—	$0
2018-09-18	Complaint	0	—	$0
2014-06-17	Planned	0	—	$0
2014-03-06	Unprogrammed Related	0	—	$0
2014-01-02	Unprogrammed Related	0	—	$0
2012-05-03	Planned	0	—	$0
2010-07-07	Unprogrammed Related	0	—	$0
2010-05-27	Unprogrammed Related	0	—	$0
2010-03-23	Complaint	0	—	$0
2008-09-03	Complaint	0	—	$0
2005-05-26	Complaint	0	—	$0
2004-03-25	Referral	2	1	$210
2003-07-24	Referral	0	—	$0
2003-07-15	Complaint	0	—	$0
2003-07-15	Complaint	0	—	$0
2002-05-15	Referral	0	—	$0
2002-04-01	Complaint	3	3	$1,350
2002-04-01	Complaint	14	9	$11,838
1999-08-20	Planned	1	—	$0
1998-07-09	Accident	3	3	$1,575
1995-01-10	Referral	0	—	$0
1992-08-17	Complaint	6	5	$1,800
1990-11-29	Complaint	5	5	$1,330
1987-03-25	Accident	0	—	$0

Source: OSHA IMIS. Citation amounts reflect initially assessed penalties; final amounts after appeal may differ.

In the news

Part of a larger organization

UNIVERSITY OF SOUTH CAROLINA is one of 668 establishments rolled up under the parent organization Aramark.

Federal enforcement records on this page represent activity at this specific establishment only. The full enforcement footprint of Aramark across all 668 of its tracked locations is viewable on the parent profile.

Other employers in this industry and state

Other employers in colleges, universities, and professional schools within SC, ordered by federal enforcement volume:

VOORHEES COLLEGEDENMARK — 2 federal enforcement records
MEDICAL UNIVERSITY OF SOUTH CAROLINA - MUSCCHARLESTON — 2 federal enforcement records
BOB JONES UNIVERSITYGREENVILLE — 2 federal enforcement records
CLEMSON UNIVERSITYCLEMSON — 1 federal enforcement record
COLLEGE OF CHARLESTONCHARLESTON — 1 federal enforcement record
UNIVERSITY OF SOUTH CAROLINACOLUMBIA — 1 federal enforcement record
SOUTHERN WESLEYAN UNIVERSITYCENTRAL — 1 federal enforcement record
COASTAL CAROLINA UNIVERSITYCONWAY — 1 federal enforcement record
ORANGEBURG-CALHOUN TECHNICAL COLLEGEORANGEBURG — 1 federal enforcement record
SOUTH CAROLINA STATE UNIVERSITYORANGEBURG — 1 federal enforcement record

Other locations under this parent

Other establishments operated by Aramark, ordered by federal enforcement volume:

ARAMARK UNIFORM SERVICESUNION, NJ — 3 federal enforcement records
ARAMARK UNIFORM SERVICESSOUTH BEND, IN — 3 federal enforcement records
ARAMARK UNIFORM SERVICESINDIANAPOLIS, IN — 3 federal enforcement records
ARAMARK UNIFORM SERVICESEVANSVILLE, IN — 3 federal enforcement records
ARAMARK UNIFORM SERVICESTERRE HAUTE, IN — 3 federal enforcement records
ARAMARKTINLEY PARK, IL — 2 federal enforcement records
ARAMARKLos Alamos, NM — 2 federal enforcement records
ARAMARK UNIFORM & CAREER APPAREL INCKENT, WA — 2 federal enforcement records
ARAMARK MANAGEMENT SERVICES LIMITED PARTNERSHIPSOUTH ORANGE, NJ — 2 federal enforcement records
Aramark Uniform ServicesReading, PA — 2 federal enforcement records