What is Texas Southern University's OSHA violation history?

Texas Southern University has no OSHA inspections on record.

How does Texas Southern University's safety record compare to its industry?

Texas Southern University operates in the colleges, universities, and professional schools industry. The industry average Total Recordable Incident Rate (TRIR) is 1.7.

Establishment profile

Texas Southern University

3100 Cleburne Street, HOUSTON, TX, 77004
611310 — Colleges, Universities, and Professional Schools

Download as PDF →

OSHA inspections

over 18 years

Violations

Penalties

Context

No OSHA inspections on record. This does not mean the employer is violation-free — OSHA inspects a small fraction of workplaces annually.

Summary

Texas Southern University has no OSHA inspection history on file. Federal records covering wage, environmental, labor relations, and other agencies are noted below where present.

The most recent federal enforcement activity was recorded 2 years ago.

Federal records were found in 1 of 15 sources. Sources without matching records returned empty for this establishment.

Agency coverage

Texas Southern University appears in WHD wage enforcement and OFLC visa and labor certification (historical) records only. No matching records were found in OSHA workplace safety, MSHA mine safety, EPA environmental compliance, NLRB labor relations, FMCSA motor carrier registration, SAM.gov federal debarment, CMS nursing home enforcement, UVA Corporate Prosecution Registry, CPSC product recalls, or NHTSA vehicle recalls.

OSHA workplace safety

No OSHA inspections, citations, or accidents on file for Texas Southern University. Verify directly with Occupational Safety and Health Administration →

Safety self-report (OSHA 300A)

No self-reported injury rates filed with OSHA's Injury Tracking Application for Texas Southern University. Verify directly with OSHA Injury Tracking Application →

Industry benchmark

Industry avg TRIR

1.7

BLS SOII 2024

Industry avg DART

0.8

BLS SOII 2024

Self-reported TRIR

—

Not in OSHA ITA

BLS rates reflect industry-wide averages. Self-reported figures come from OSHA’s Injury Tracking Application; absence of self-reported data does not necessarily indicate non-compliance — many establishments fall below the ITA reporting threshold.

OSHA severe injury reports

No severe injury reports (hospitalization, amputation, or loss of an eye) on file under 29 CFR 1904.39 for Texas Southern University. Verify directly with Occupational Safety and Health Administration →

Activity timeline

Data refreshed

Weekly

First OSHA inspection

—

Most recent activity

2 years ago

No federal enforcement activity has been recorded against this establishment in 2+ years. Most recent activity: 2 years ago. Data on this page is refreshed weekly.

Wage & Hour Division (WHD)

Cases

Back wages owed

$5,724

Employees affected

Department of Labor Wage & Hour Division — minimum-wage, overtime, child-labor, FMLA, and prevailing-wage enforcement.

Wage and hour breakdown by law

Per-statute totals across all closed DOL Wage & Hour cases against this employer. Backwages reflect amounts the agency assessed; civil penalty is the separate fine where applicable. Some acts (Davis-Bacon, SCA, CWHSSA, H-2B, CCPA) don't carry a civil penalty field in DOL's data. 2 statutes · 15 violations · $5,724 in backwages

Statute	Period	Cases	Violations	Workers	Backwages	Civil penalty
FMLA (family & medical leave)	Nov 2007 – May 2018	3	7	1	$5,000	—
FLSA — minimum wage & overtime	Apr 2008 – Oct 2023	2	8	7	$724	—

Source: DOL WHD enforcement database, aggregated per statute. Lifetime totals. A case can cite multiple statutes — so the total here may exceed the case count in the table above.

Wage and hour cases

Closed DOL Wage & Hour Division cases (FLSA, FMLA, H-2B, MSPA, and related statutes). Backwages reflect amounts the agency assessed; civil penalty (CMP) is a separate fine levied on top, where the statute provides for one (FLSA / H-1B / H-2A / MSPA / FMLA / EPPA / FLSA Child Labor; other acts have no CMP column in DOL’s data). The Statutes column lists which laws each case cited. 5 cases · 15 violations · $5,724 in backwages · 10 workers affected

Case period	Industry	Statutes	Violations	Workers	Backwages	Civil penalty
Oct 2021 – Oct 2023	Colleges, Universities, and Professional Schools	FLSA	7	7	$724	—
Feb 2018 – May 2018	Colleges, Universities, and Professional Schools	FMLA	5	1	—	—
Sep 2012	State Institutions of Higher Education	FMLA	1	1	$5,000	—
Apr 2006 – Apr 2008	State Institutions of Higher Education	FLSA	1	0	—	—
Oct 2007 – Nov 2007	Colleges, Universities, and Professional Schools	FMLA	1	1	—	—

Source: DOL WHD enforcement database. Cases shown reflect those the agency has closed and made public. A violation count is the agency’s tally of cited violations (one violation can affect many workers); the workers column counts distinct employees the agency found to be affected.

Mine safety (MSHA)

No MSHA mine safety violations on file for Texas Southern University. Verify directly with Mine Safety and Health Administration →

Labor relations (NLRB)

No NLRB unfair labor practice charges or union representation cases on file for Texas Southern University. Verify directly with National Labor Relations Board →

Visa & labor certification (OFLC) — historical

Total applications

Certified

Avg wage ratio

1.25x

H-1B

Office of Foreign Labor Certification — labor condition applications for H-1B, H-2A, H-2B visa programs. Wage ratio = offered / prevailing wage. Historical data only: DOL ended OFLC Performance Data Disclosure publication in 2026, so the figures above reflect filings through the last ingested cycle and are not being refreshed. Treat as a historical snapshot, not a current signal.

Environmental compliance (EPA)

No EPA inspections or formal enforcement actions on file for Texas Southern University. Verify directly with Environmental Protection Agency →

EPA-registered facilities

Every EPA ECHO facility associated with this employer, sorted most-significant first. Each row links to EPA’s Detailed Facility Report for the source-of-truth record. Permits column lists active programs (Air = Clean Air Act, Water = Clean Water Act, RCRA = hazardous waste, TRI = Toxics Release Inventory reporting). 1 facility · 1 marked inactive.

Facility	Permits	Status	Inspections	Formal actions	Penalties	Last inspected	ECHO
TEXAS SOUTHERN UNIVERSITY 3201 WHEELER ST · HOUSTON, TX, 77004	—	—	0	0	—	—	View →

Source: EPA ECHO (Enforcement and Compliance History Online). Compliance status follows EPA’s own labels (“Sig Violation” = significant noncompliance; QNCR = quarters of noncompliance over the recent reporting window). Inactive facilities (struck through) retain historical enforcement records even after operations ceased.

Federal criminal prosecution record

No federal criminal prosecutions, plea agreements, or deferred-prosecution agreements on file for Texas Southern University. Verify directly with UVA Corporate Prosecution Registry →

Federal contracts

This location

Obligated (5-yr)

$188K

Obligated (all-time)

$574K

Awards

Top agency

Smithsonian Institution

$316K

Top agencies by obligation (this location)

Smithsonian Institution$316K

Department of Defense$174K

Department of Homeland Security$51K

Department of Veterans Affairs$20K

Department of State$15K

Largest awards

Department of Education
HISTORICALLY BLACK COLLEGES AND UNIVERSITIES PROGRAM
assistance · Last action 2025-09-27
$48,878,901
Department of Education
PROVIDE EMERGENCY AID ASSISTANCE TO STUDENTS AND AS APPROPRIATE TO INSTITUTIONAL NEEDS RELATED DIRECTLY TO THE DISRUPTION IN SERVICES DUE TO THE CORONAVIRUS PANDEMIC
assistance · Last action 2021-05-14
$36,354,508
Department of Education
GRANT PROGRAM
assistance · Last action 2025-12-08
$35,457,492
Department of Education
GRANT PROGRAM
assistance · Last action 2026-05-19
$34,293,421
Department of Education
GRANT PROGRAM
assistance · Last action 2025-10-31
$26,457,511
Department of Education
UNKNOWN TITLE
assistance · Last action 2023-07-10
$25,644,074
Department of Education
UNKNOWN TITLE
assistance · Last action 2025-10-18
$25,232,816
Department of Health and Human Services
CENTER FOR BIOMEDICAL AND MINORITY HEALTH RESEARCH
assistance · Last action 2026-04-06
$13,379,927
Department of Education
TITLE III, PART B STRENGTHENING HISTORICALLY BLACK GRADUATE INSTITUTIONS (HBGI) PROGRAM
assistance · Last action 2025-09-08
$10,836,164
Department of Education
HISTORICALLY BLACK COLLEGES AND UNIVERSITIES PROGRAM (FUTURE ACT)
assistance · Last action 2024-07-06
$7,432,961
Department of Education
PATH TO R1 AT TEXAS SOUTHERN UNIVERSITY
assistance · Last action 2023-12-08
$4,996,543
National Science Foundation
HOUSTON - LOUIS STOKES STEM PATHWAYS AND RESEARCH ALLIANCE
assistance · Last action 2022-09-19
$4,000,000
Department of Health and Human Services
SCHOLARSHIPS FOR DISADVANTAGED STUDENTS
assistance · Last action 2026-06-04
$3,242,468
Department of Housing and Urban Development
GENERAL RESEARCH AND TECHNOLOGY ACTIVITY
assistance · Last action 2023-09-06
$3,000,000
Department of Education
U.S. DEPARTMENT OF EDUCATION FEDERAL TRIO PROGRAMS TALENT SEARCH
assistance · Last action 2025-09-18
$2,757,961
Department of Health and Human Services
SCHOLARSHIPS FOR DISADVANTAGED STUDENTS
assistance · Last action 2026-06-15
$2,698,467
Department of Education
UPWARD BOUND PROGRAM - TEXAS SOUTHERN UNIVERSITY- (KASHMERE, WHEATLEY, STERLING)
assistance · Last action 2025-09-18
$2,033,046
Department of Health and Human Services
COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - TSU HAS DESIGNED A PLAN TO ENGAGE IN A MULTI-PHASE / MULTI-YEAR REHABILITATION PROJECT TO MODERNIZE THE W. R. BANKS CHILD DEVELOPMENT CENTER, A SIX THOUSAND SQUARE FOOT SINGLE-STORY BUILDING AND CREATE THE INSTITUTE FOR URBAN PUBLIC HEALTH AND HOUSING EQUITY, AN URBAN RENEWAL PROGRAMMING INITIATIVE. TEXAS SOUTHERN UNIVERSITY’S INSTITUTE FOR URBAN PUBIC HEALTH AND HOUSING EQUITY INITIATIVE IS BEING DESIGNED TO ADDRESS SOCIAL DETERMINANTS OF HEALTH IN HISTORICALLY UNDESERVED COMMUNITIES AND INCREASE OPPORTUNITIES FOR MINORITY HEALTH CARE PROFESSIONALS THROUGH TRAINING AND RESEARCH. AT ITS CORE, THE INSTITUTE WILL BE DEVELOPED WITH THE NEIGHBORING PUBLIC HOUSING DEVELOPMENT, CUNEY HOMES’ RESIDENTS AND THE SURROUNDING COMMUNITY IN MIND. THE INSTITUTE WILL FOCUS ON DEVELOPING SKILLS AND PROVIDING ONGOING TRAINING AND CERTIFICATION FOR PROFESSIONALS TO SERVE AS “FRONTLINE” HEALTH CARE PROVIDERS AND COMMUNITY ADVOCATES. FURTHERMORE, THE INSTITUTE WILL GROW THE UNDERSTANDING OF HEALTH DISPARITIES AND HOUSING INEQUITY WITHIN A COMMUNITY ENGAGEMENT ENVIRONMENT. MR. LARENCE SNOWDEN, ASSISTANT VICE PRESIDENT FOR CORPORATE-COMMUNITY PARTNERSHIPS AND CAREER PATHWAYS (PI) AND PROJECT DIRECTOR (PD) WILL SERVE AS HAVE SENIOR OVERSIGHT AND ADMINISTRATION OF THE INSTITUTE PROJECT. THE TOTAL TSU INSTITUTE FOR URBAN PUBLIC HEALTH AND HOUSING EQUITY RENOVATION PROJECT COST IS $2,000,000. THIS HRSA CONSTRUCTION/EQUIPMENT PROJECT REQUESTS $2,000,000 IN FUNDING TO COVER THE TOTAL CONSTRUCTION, RENOVATION, MODERNIZATION, AND EQUIPMENT COSTS.
assistance · Last action 2025-12-16
$2,000,000
National Science Foundation
LOUIS STOKES RENEWAL STEM PATHWAYS AND RESEARCH ALLIANCE: HOUSTON LOUIS STOKES ALLIANCE FOR MINORITY PARTICIPATION -THE LOUIS STOKES ALLIANCES FOR MINORITY PARTICIPATION (LSAMP) PROGRAM ASSISTS UNIVERSITIES AND COLLEGES IN THEIR EFFORTS TO SIGNIFICANTLY INCREASE THE NUMBERS OF STUDENTS MATRICULATING INTO AND SUCCESSFULLY COMPLETING HIGH QUALITY DEGREE PROGRAMS IN SCIENCE, TECHNOLOGY, ENGINEERING AND MATHEMATICS (STEM) DISCIPLINES TO DIVERSIFY THE STEM WORKFORCE. PARTICULAR EMPHASIS IS PLACED ON TRANSFORMING UNDERGRADUATE STEM EDUCATION THROUGH INNOVATIVE, EVIDENCE-BASED RECRUITMENT AND RETENTION STRATEGIES, AND RELEVANT EDUCATIONAL EXPERIENCES IN SUPPORT OF POPULATIONS UNDERREPRESENTED IN STEM DISCIPLINES: AFRICAN AMERICANS, HISPANIC AMERICANS, AMERICAN INDIANS, ALASKA NATIVES, NATIVE HAWAIIANS, AND NATIVE PACIFIC ISLANDERS. THESE STRATEGIES FACILITATE THE PRODUCTION OF WELL-PREPARED STUDENTS HIGHLY QUALIFIED AND MOTIVATED TO PURSUE GRADUATE EDUCATION OR CAREERS IN STEM. FOR THE UNITED STATES TO REMAIN GLOBALLY COMPETITIVE, IT IS VITAL THAT IT TAPS INTO THE TALENT OF ALL ITS CITIZENS AND PROVIDES EXCEPTIONAL EDUCATIONAL PREPAREDNESS IN STEM AREAS THAT UNDERPIN THE KNOWLEDGE-BASED ECONOMY. THE HOUSTON LSAMP STEM PATHWAYS & RESEARCH ALLIANCE (H-LSAMP) HAS FORMED AN ALLIANCE IN RESPONSE TO THE NEED FOR A MORE DIVERSE AND SKILLED TECHNICAL WORKFORCE. THAT NEED STILL EXISTS AND IS PARTICULARLY ACUTE IN TEXAS. THE INSTITUTIONS THAT MAKE UP THE ALLIANCE ARE DIVERSE AND INCLUDE TEXAS SOUTHERN UNIVERSITY (THE LEAD INSTITUTION), TEXAS STATE UNIVERSITY, THE UNIVERSITY OF HOUSTON, THE UNIVERSITY OF HOUSTON-DOWNTOWN, AND THE UNIVERSITY OF HOUSTON-CLEAR LAKE. THROUGH THIS PROJECT, THE ALLIANCE WILL PROVIDE STUDENTS WITH RESEARCH EXPERIENCES, MENTORING, SUPPLEMENTAL INSTRUCTION OPPORTUNITIES, ACTIVITIES TO BUILD COMMUNITY AMONG STUDENTS, AND DEDICATED PROGRAM SPACE. IN ADDITION, H-LSAMP WILL BE A MODEL AND A RESOURCE IN LONGITUDINAL ASSESSMENT ANALYSIS FOR LONG-STANDING, MULTIDIMENSIONAL STUDENT SUCCESS PROGRAMS, CONTRIBUTING TO THE BODY OF KNOWLEDGE IN THE EDUCATIONAL RESEARCH SPACE. THE ALLIANCE TEAM IS ALSO COMMITTED TO DISSEMINATING LESSONS LEARNED THROUGH PRACTICE AND RESEARCH TO AUDIENCES WITHIN THE STATE, REGION AND NATIONWIDE, SUPPORTING THE NATIONAL SCIENCE FOUNDATION'S STRATEGIC GOAL TO EMPOWER STEM TALENT TO FULLY PARTICIPATE IN SCIENCE AND ENGINEERING BY IMPROVING CONDITIONS FOR MINORITIZED STUDENTS IN STEM AND HELPING BUILD A DIVERSE AND EXCELLENT STEM WORKFORCE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.
assistance · Last action 2025-07-31
$2,000,000
Department of Education
TITLE III, PART F STRENGTHENING HBCU PROGRAM FOR THE FOSTERING UNDERGRADUATE TALENT BY UNLOCKING RESOURCES FOR EDUCATION (FUTURE) ACT PROGRAM
assistance · Last action 2025-09-26
$1,566,217
Department of Health and Human Services
MATERNAL HEALTH RESEARCH NETWORK (MH-RN) FOR MSIS--RESEARCH AWARDS
assistance · Last action 2026-03-13
$1,383,394
Department of Education
TRIO STUDENT SUPPORT SERVICES STEM-TEXAS SOUTHERN UNIVERSITY
assistance · Last action 2024-07-12
$1,330,392
Department of Education
TRIO STUDENT SUPPORT SERVICES
assistance · Last action 2024-07-12
$1,330,392
Department of Education
UPWARD BOUND MATH AND SCIENCE PROGRAM - MADISON - TEXAS SOUTHERN UNIVERSITY
assistance · Last action 2025-08-19
$1,226,116
Department of Health and Human Services
THE TSU SHAPE INITIATIVE: BRUTHAS PROJECT - THE TSU SHAPE INITIATIVE: BRUTHAS PROJECT IS A TEXAS SOUTHERN UNIVERSITY CAMPUS AND GREATER COMMUNITY-BASED SERVICE PROVIDER PARTNERSHIP. THE PARTNERSHIP IS DESIGNED TO EXPAND AND ENHANCE ACCESS TO TREATMENT OF SUBSTANCE USE DISORDERS (SUD), HIV, HEPATITIS-C AND STI PREVENTION SERVICES PRIMARILY AMONG AT-RISK ETHNIC/SEXUAL MINORITY MALES IN HOUSTON/HARRIS COUNTY. THE OVERALL HIV BURDEN (INCIDENCE RATE OF 21.6-25.6; PREVALENCE RATE OF 464.6-566.8) WITHIN HOUSTON/HARRIS COUNTY, TEXAS IS GREATER THAN THAT REPORTED AT THE STATE (INCIDENCE RATE OF 15.7; PREVALENCE RATE OF 327.9) AND NATIONAL LEVEL(INCIDENCE RATE OF 11.4; PREVALENCE RATE OF 308.7). IN HOUSTON/HARRIS COUNTY, AFRICAN AMERICANS (45%) AND HISPANICS (38%) ACCOUNTED FOR MOST NEW HIV 2018 DIAGNOSES (OVER 1,200, 9% INCREASE FROM 2017) AND MALE-TO-MALE CONTACT (68%) REPRESENTED THE GREATEST CATEGORY OF TRANSMISSION. THE TSU SHAPE INITIATIVE: BRUTHAS PROJECT IS AN INNOVATIVE PROGRAM HOUSED WITHIN A UNIVERSITY ACADEMIC UNIVERSITY ENVIRONMENT THAT CAN ACCOMMODATE THE FLUIDITY OF SUCH A DIVERSE TARGET POPULATION. AS SUCH, THE PROJECT WILL IMPLEMENT SERVICES WITHIN A LOCALITY THAT IS HARDEST HIT BY THE HIV EPIDEMIC. ITS PRIORITY POPULATION IS AFRICAN AMERICAN AND HISPANIC YMSM/MSM 16 YEARS AND OLDER THROUGHOUT GREATER HOUSTON WHO ARE AT-RISK FOR HIV, VIRAL HEPATITIS, SUBSTANCE MISUSE, AND/OR POOR MENTAL HEALTH OUTCOMES. THE BRUTHAS PROJECT AN IDEAL COMPLEMENTARY PROGRAM THAT CAN EFFECTIVELY ADDRESS THE UNIQUE NEEDS OF ETHNIC MINORITY YMSM/MSM THROUGHOUT THE GREATER HOUSTON COMMUNITY. GOALS OF THE BRUTHAS PROJECT ARE TO 1) INCREASE ACCESS TO HIV AND HEPATITIS CLINICAL CARE SERVICES FOR SEXUAL AND ETHNIC MINORITY MALES; 2) IMPLEMENT PREVENTION STRATEGIES THAT REDUCE SUBSTANCE USE, POOR MENTAL HEALTH OUTCOMES, SEXUAL RISK, AND ENVIRONMENTAL BARRIERS AMONG SEXUAL AND ETHNIC MINORITY MALES; 3) DEVELOP, UTILIZE, AND DISSEMINATE ENVIRONMENTAL STRATEGIES TO ENGAGE SEXUAL AND ETHNIC MINORITY MALES. THE BRUTHAS PROJECT FURTHER COMMITS TO DELIVERING CULTURALLY GROUNDED PREVENTION STRATEGIES TO INCLUDE STATUS NEUTRAL FRAMEWORK AND SERVICE APPROACH, REDUCED COUNSELING, TESTING, AND REFERRAL RAPID-TEST APPROACH, COMMUNITY PROMISE FOR HIGH IMPACT PREVENTION (HIP), GROUP-EDUCATION SESSION MODEL, (TRANSFORM) TRANSFORMING FROM HIV PREVENTION PRACTICE TO PREVENTION INNOVATION: COMPREHENSIVE HIV CARE DELIVERY FOR MSM OF COLOR AND THE BRUTHAS PROJECT EVIDENCE-BASED INTERVENTION. THE EVIDENCE-BASE INTERVENTIONS AND/OR PROMISING PRACTICES HIGHLIGHTED ABOVE WILL CONTRIBUTE TO ADDRESSING DISPARITIES IN SERVICE ACCESS, USE, AND OUTCOMES. THE BRUTHAS PROJECT WILL PROVIDE DIRECT CLINICAL TESTING SERVICES TO AN ANNUAL MINIMUM OF 50-125 HOUSTON/HARRIS COUNTY RESIDENTS FOR A TOTAL OF 435 UNDUPLICATED PARTICIPANTS IDENTIFYING AS YMSM/MSM AND/OR ENGAGED IN SIMILARLY CONSISTENT BEHAVIORS RECEIVING HIV, HEPATITIS-C AND/STI SCREENING OVER A FIVE YEAR PERIOD. OF THESE, APPROXIMATELY10: )43-45 PARTICIPANTS) WILL ENROLL IN AN INTENSIVE EVIDENCE-BASED INTERVENTION PROGRAM DESIGNED TO REDUCE INDIVIDUAL SEXUAL RISK FACTORS AND BETTER ADDRESS UNIQUE SOCIAL DETERMINANTS IMPACTING OVERALL WELLBEING.
assistance · Last action 2026-01-19
$1,000,000
Department of Housing and Urban Development
GENERAL RESEARCH AND TECHNOLOGY ACTIVITY
assistance · Last action 2021-09-21
$1,000,000
National Science Foundation
COLLABORATIVE RESEARCH: IMPROVING ACCESS TO CAREER AND EDUCATIONAL DEVELOPMENT FOR TALENTED, LOW-INCOME STUDENTS THROUGH THE FLEXIBLE INTERNSHIPS-RESEARCH-EDUCATION MODEL
assistance · Last action 2021-08-19
$954,605
Department of Education
CAMPUS BASED-FWS
assistance · Last action 2025-04-10
$920,729
Department of Education
CAMPUS BASED-FWS
assistance · Last action 2024-03-29
$920,729
National Science Foundation
ESTABLISHMENT OF RESEARCH AND EDUCATION PARTNERSHIPS FOR UNDERREPRESENTED STUDENTS IN BIOPHYSICS AT TEXAS SOUTHERN UNIVERSITY -THIS AWARD IS FUNDED IN WHOLE OR IN PART UNDER THE AMERICAN RESCUE PLAN ACT OF 2021 (PUBLIC LAW 117-2). THE AWARD SUPPORTS TEXAS SOUTHERN UNIVERSITY (TSU) IN A PARTNERSHIP WITH THE CENTER FOR THEORETICAL BIOLOGICAL PHYSICS (CTBP, RICE UNIVERSITY) IN A COLLABORATIVE RESEARCH AND TRAINING PROGRAM. THIS COLLABORATION WILL IMPACT STUDENTS FROM UNDERREPRESENTED AND UNDERSERVED COMMUNITIES, AS IS CONSISTENT WITH THE LARGEST SEGMENT OF THE STUDENT POPULATION ON THE TSU CAMPUS (GREATER THAN 80%). THIS NSF-PREP PROJECT IS AIMED AT IMPROVING THE RETENTION AND ACADEMIC PREPAREDNESS OF GRADUATES WHO SUCCESSFULLY GO TO GRADUATE SCHOOL, MEDICAL SCHOOL OR SUCCESSFUL BIOPHYSICS CAREERS AND RELATED SCIENCES. RESEARCH PROJECTS CONCERN THE EFFECT OF LOW DOSE RADIATION ON CELLS AND THEIR GENETICS, WITH A FOCUS ON DEVELOPING COLLABORATIONS PARTICULARLY IN THE AREAS OF FUNDAMENTAL MODELING OF CHROMATIN STRUCTURE AND DYNAMICS, AND MODELING OF GENE SIGNALING NETWORKS COMING FROM THE CTBP SIDE. THE FUNDED ACTIVITIES INTEGRATE TEXAS SOUTHERN FACULTY AND STUDENT EFFORTS AND TRAINING WITH THE ACTIVITIES OF THE CTBP. THE COLLABORATION HAS TWO MAIN RESEARCH PROJECTS: (1) DETERMINING MECHANISMS THAT AFFECT CELL PROLIFERATION AT LOW X-RAY DOSES CONSISTENT WITH DIAGNOSTIC IMAGING ENERGIES AND (2) UNDERSTANDING HOW LOW DOSE X-RAYS AFFECT LEUKOCYTES, POST-EXPOSURE MOLECULAR RESPONSE PATHWAYS AND REPAIR MECHANISMS AND PHENOTYPIC IMPACT ON CELL PROLIFERATION. THE OBJECTIVES WILL BE ACCOMPLISHED BY EMPHASIZING THREE DISTINCT THRUSTS: (1) COMPUTATIONAL MODELING AND THEORY-BASED INVESTIGATION OF CHANGES IN BIOLOGICALLY RELEVANT PROCESSES, LINEAR ENERGY TRANSFER (LET) AND RELATIVE BIOLOGICAL EFFECTIVENESS (RBE) ENGENDERED BY X-RAY IRRADIATION IN REALISTIC LEUKOCYTE CELL MORPHOLOGIES CONSISTING OF LIQUID WATER AT RELATIVELY LOW DOSES, (2) EXPERIMENTAL AND COMPUTATIONAL EVALUATION OF RADIATION DAMAGE AT THE DNA SCALE DUE TO X-RAY IRRADIATION AT RELATIVELY LOW DOSES, AND (3) VALIDATION AND TESTING OF COMPUTATIONAL MODELS WITH BIOLOGICAL EXPERIMENTS EXPLORING THE FUNCTIONAL IMPACT OF LOW DOSE X-RAYS ON PROTEIN-PROTEIN AND PROTEIN-SMALL MOLECULE INTERACTIONS. ESTABLISHMENT OF A STRONG PARTNERSHIP BETWEEN TSU AND THE CTBP WILL PROVIDE A PIPELINE FOR A HIGH-ACHIEVING AND DIVERSE STUDENT POPULATION WITH TRAINING IN THEORETICAL BIOPHYSICS AND EXPERIMENTAL RADIATION BIOLOGY RESEARCH TO CONTINUE TO GRADUATE OR MEDICAL SCHOOL, RESPECTIVELY. THE DUAL ASPECT OF STUDENT MENTORS IN ACTIVE LEARNING AND RESEARCH EXPERIENCES ARE PRIMARY COMPONENTS OF THIS TARGETED ENDEAVOR. FOR ALL STUDENTS, MOST OF THE ATTRITION OCCURS IN THE FIRST TWO YEARS OF COLLEGE, WHEN STUDENTS ARE TAKING INTRODUCTORY GATEWAY COURSES. THE GRANT WILL ENABLE TSU TO CREATE AND BUILD A SUCCESSFUL BIOPHYSICS PROGRAM IN PARTNERSHIP WITH THE CTBP. TSU IS LOCATED WITHIN HOUSTON AND IS ONE OF THE LARGEST HISTORICALLY BLACK COLLEGES AND UNIVERSITIES (HBCUS) IN THE NATION. UNDERREPRESENTED STEM STUDENTS WILL NATURALLY BE IMPACTED BY THE ACADEMIC AND RESEARCH THRUSTS OUTLINED IN THE PROPOSAL. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
assistance · Last action 2023-07-11
$899,976
Department of Education
MCNAIR PROGRAM - TEXAS SOUTHERN UNIVERSITY
assistance · Last action 2024-07-10
$806,616
Department of Education
CAMPUS BASED-FSEOG
assistance · Last action 2026-03-20
$776,457
Department of Health and Human Services
2/2 COLLABORATIVE UNION FOR CANCER RESEARCH, EDUCATION, AND DISPARITIES (CURED) - CURED OVERALL ABSTRACT DAN L DUNCAN COMPREHENSIVE CANCER CENTER (DLDCCC) AT BAYLOR COLLEGE OF MEDICINE (BCM) AND TEXAS SOUTHERN UNIVERSITY (TSU) ARE JOINTLY SUBMITTING A P20 APPLICATION TO BUILD A COLLABORATIVE PARTNERSHIP IN CANCER RESEARCH, EDUCATION, AND OUTREACH. DLDCCC IS A NATIONAL CANCER INSTITUTE (NCI) DESIGNATED CANCER CENTER. TSU IS ONE OF THE NATION’S LARGEST HISTORICALLY BLACK COLLEGES AND UNIVERSITIES (HBCU) SERVING UNDERSERVED POPULATIONS AND UNDERREPRESENTED STUDENTS (ISUPSS). BCM AND TSU HAVE HAD SEVERAL SUCCESSFUL COLLABORATIONS. THIS RELATIONSHIP WAS STRENGTHENED RECENTLY THROUGH TSU’S U54 “CENTER FOR BIOMEDICAL AND MINORITY HEALTH RESEARCH”, WHERE BCM FACULTY HAVE PARTNERED CLOSELY ON COLLABORATIVE CANCER DISPARITIES COMMUNITY EDUCATION AND OUTREACH. THIS P20 PROGRAM PROVIDES AN EXCELLENT OPPORTUNITY FOR TSU AND BCM TO EXPAND COLLABORATIONS. WE PROPOSE A BCM-TSU P20 PROGRAM “COLLABORATIVE UNION FOR CANCER RESEARCH, EDUCATION AND DISPARITIES” (CURED) THAT WILL FOSTER STRONG COLLABORATIONS UTILIZING OUR COMPLEMENTARY STRENGTHS. OVERALL OBJECTIVES ARE TO CREATE A SHARED INFRASTRUCTURE THAT WILL PROVIDE AN OPTIMAL ENVIRONMENT FOR CANCER RESEARCH, EDUCATION, COMMUNITY OUTREACH, AND CAREER DEVELOPMENT AND DIVERSIFY THE BIOMEDICAL WORKFORCE. CURED WAS ESTABLISHED UNDER THE DIRECTION OF SENIOR LEADERSHIP AT EACH INSTITUTION, REFLECTED IN THE SIGNIFICANT INSTITUTIONAL SUPPORT FOR THIS PARTNERSHIP. BCM HAS COMMITTED $160,000/YEAR FOR FOUR YEARS IN COST MATCHING FUNDS, $ 50,000 FOR PILOT PROJECT 2 FOR ONE YEAR, AND COMMITTED FUNDS TO SUPPORT THE TRAINING OF TSU SUMMER STUDENTS IN THE CANCER RESEARCH EDUCATION PROGRAM. TSU HAS COMMITTED TO RETURN THE INDIRECT COST ALLOCATION AMOUNTING TO $98,000 EACH YEAR. ALL TSU INVESTIGATORS ARE MEMBERS OF THE DLDCCC. LEADERS OF EACH INSTITUTION ARE THUS COMMITTED TO EMPOWER THE P20 PARTNERSHIP TO ADDRESS CANCER HEALTH DISPARITIES AMONG URM AND UNDERSERVED POPULATIONS IN HOUSTON. OUR GOALS ARE TO (1) ESTABLISH A COLLABORATIVE ALLIANCE BETWEEN BCM AND TSU FOR CANCER RESEARCH, EDUCATION, AND COMMUNITY OUTREACH. WE WILL (A) ESTABLISH CURED OFFICES IN BOTH INSTITUTIONS THAT WILL PROVIDE COORDINATION FOR RELEVANT ACTIVITIES, EVALUATE PROGRESS OF CURRENT PROJECTS, AND ENSURE A PIPELINE OF INNOVATIVE PILOT PROJECTS; (B) CENTRALIZE INSTITUTIONAL RESOURCES FOR FACULTY/TRAINEE RESEARCH NEEDS (C) LEAD A CANCER RESEARCH AND CAREER DEVELOPMENT PROGRAM FOR TSU STUDENTS THAT INCLUDES MENTORED CANCER RESEARCH, AN EDUCATIONAL CURRICULUM, HANDS-ON TRAINING IN EMERGING TECHNOLOGIES, AND PROFESSIONAL DEVELOPMENT; (D) BUILD A BCM/TSU COMPREHENSIVE OUTREACH PROGRAM TO ADDRESS CANCER DISPARITIES AT THE BENCH, BEDSIDE, AND WITHIN THE COMMUNITY; AND (2) TO SUPPORT A PIPELINE OF COLLABORATIVE INNOVATIVE CANCER RESEARCH PILOT PROJECTS. OVERALL IMPACT: WE ARE CERTAIN THAT THE PROPOSED CURED WILL ENHANCE CANCER RESEARCH EDUCATION CAPACITY AT TSU, PROMOTE A DIVERSE RESEARCH WORKFORCE, AND IMPROVE BCM/DLDCCC’S EFFECTIVENESS IN DEVELOPING AND SUSTAINING RESEARCH PROGRAMS FOCUSED ON CANCER HEALTH DISPARITIES. WE WILL DEVELOP SUSTAINABLE RESEARCH CAPACITY LEADING TO INDEPENDENT AND COLLABORATIVE APPLICATIONS TO THE NIH/OTHER FEDERAL/NON-FEDERAL AGENCIES.
assistance · Last action 2025-09-08
$759,862
Department of Education
TSU VETERANS FOR EXCELLENCE CENTER
assistance · Last action 2024-11-08
$740,988
Department of Energy
PARTNERSHIP FOR FOSTERING GRADUATE TRAINING IN ATMOSPHERIC SCIENCES AT TEXAS SOUTHERN UNIVERSITY
assistance · Last action 2025-07-01
$719,702
Department of Education
CAMPUS BASED-FSEOG
assistance · Last action 2025-04-10
$660,885
Department of Health and Human Services
SELECTIVELY MANIPULATING INTESTINAL GLUCURONIDATION TO ALLEVIATE MYCOPHENOLATE MOFETIL-INDUCED DIARRHEA - PROJECT TITLE: SELECTIVELY MANIPULATING INTESTINAL GLUCURONIDATION TO ALLEVIATE MYCOPHENOLATE MOFETIL-INDUCED DIARRHEA ABSTRACT: GLUCURONIDATION IN THE GI TRACT USUALLY IS A DETOXIFICATION PROCEDURE FOR PHENOLIC DRUGS USED TO TREAT DISEASES ON THE OTHER ORGANS. FOR MANY OF THESE DRUGS, GLUCURONIDATION IN THE GI TRACT IS INSUFFICIENT, RESULTING IN EXCESSIVE DRUG ACCUMULATION IN THE LOWER GI SEGMENTS (I.E., ILEUM AND COLON) TO CAUSE LOCAL TOXICITY (E.G., DIARRHEA, CONSTIPATION). OUR LONG-TERM GOAL IS TO DEVELOP SAFE AND EFFECTIVE AGENTS TO SELECTIVELY MANIPULATING GLUCURONIDATION IN THE LOWER GI TRACT TO BOOST LOCAL DETOXIFICATION WITHOUT COMPROMISING PLASMA DRUG EXPOSURE AND EFFICACY FOR BETTER THERAPEUTIC OUTCOMES. IN THIS APPLICATION, WE PROPOSE TO USE MYCOPHENOLATE MOFETIL (MMF), A PRODRUG OF MYCOPHENOLIC ACID (MPA) USED TO PREVENT REJECTION IN ORGAN TRANSPLANT PATIENTS, AS THE MODEL DRUG TO PROVE THE PRINCIPLE-OF-CONCEPT. CLINICAL STUDIES HAVE SHOWN THAT MORE THAN 20% OF ORGAN TRANSPLANT PATIENTS WITH MMF TREATMENT SUFFER FROM CHRONIC DIARRHEA, WHICH SIGNIFICANTLY DOWNGRADES PATIENTS' QUALITY OF LIVES AND DOUBLES GRAFT LOSS INCIDENCE. IN THE PRELIMINARY STUDY, WE FOUND THAT WOGONIN AND CHRYSIN, TWO COMPOUNDS THAT ARE ONLY BIOAVAILABLE IN THE LOWER GI TRACT DUE TO TWO NOVEL RECYCLINGS MECHANISMS DISCOVERED BY US RECENTLY, CAN EFFECTIVELY ATTENUATE MMF-INDUCED DIARRHEA IN RATS. IN VITRO STUDIES SHOWED THAT WOGONIN CAN INDUCE UGT1A, A SUBFAMILY OF ENZYMES CATALYZING MPA TO BE METABOLIZED INTO MPA-GLUCURONIDE (MPAG, A NON-TOXIC METABOLITE). ADDITIONALLY, IN VITRO STUDIES SHOWED THAT CHRYSIN COULD INHIBIT UGT2B7, AN ENZYME ISOFORM CATALYZING MPA TO BE METABOLIZED INTO ACYL-MPA-GLUCURONIDE (ACMPAG, A TOXIC METABOLITE). PK STUDIES IN RATS SHOWED THAT CO-ADMINISTRATION OF WOGONIN/CHRYSIN WITH MMF DIDN'T ALTER THE PLASMA EXPOSURE TO MPA, THE ACTIVE FORM FOR IMMUNOSUPPRESSION. THEREFORE, WE HYPOTHESIZE THAT SELECTIVELY AND SYNERGISTICALLY MANIPULATING MPA INTESTINAL GLUCURONIDATION BY ORGAN TARGETING AGENTS WOGONIN AND CHRYSIN COULD REDUCE LOCAL EXPOSURE TO MPA AND ACMPAG IN THE LOWER GUT TO ATTENUATE DIARRHEA INDUCED BY MMF WITHOUT AFFECTING SYSTEMIC EXPOSURE TO MPA. WE PROPOSE TWO SPECIFIC AIMS TO TEST OUR HYPOTHESIS: (1) VERIFY THE SYNERGISTIC ANTI-DIARRHEAL EFFECT OF WOG AND CHRY AND DEVELOP MORE EFFECTIVE DOSING REGIMENS USING CELLS AND ANIMAL MODELS (AIM 1); AND (2) DETERMINE THE MECHANISM OF DIARRHEA ATTENUATION BY WOG AND CHRY USING CELLS AND ANIMAL MODELS (AIM 2). SUCCESSFUL COMPLETION OF THIS PROJECT WILL ALLOW US TO PROVE THE CONCEPT OF BOOSTING LOCAL DETOXIFICATION IN THE LOWER GUT USING LOCALLY BIOAVAILABLE COMPOUNDS. SELECTIVELY MANIPULATING DRUG METABOLISM IN A SPECIFIC ORGAN USING ORGAN TARGETING AGENTS IS HIGHLY INNOVATIVE, THUS UNRAVELING AN IMPORTANT NEW PARADIGM ON MANAGEMENT OF SIDE EFFECTS IN THE GI TRACT. THIS PROJECT WILL ALLOW THE PI TO MAINTAIN AND EXPAND HIS INNOVATIVE RESEARCH IN DEVELOPING RECYCLED LOCALLY BIOAVAILABLE DRUGS. ADDITIONALLY, RECEIVING THIS AWARD WILL ALLOW THE PI TO CONTINUOUSLY ATTRACT AND TRAIN STUDENTS FROM DIFFERENT BACKGROUND, ESPECIALLY FROM UNDER-REPRESENTED MINORITY POPULATIONS, WITH MULTI-DISCIPLINARY KNOWLEDGE AND TECHNIQUES.
assistance · Last action 2026-04-17
$613,520
Department of Education
CAMPUS BASED-FSEOG
assistance · Last action 2024-02-29
$558,536
Department of Justice
THE STRENGTHENING CULTURALLY SPECIFIC CAMPUS APPROACHES TO ADDRESS DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING INITIATIVE (CSC INITIATIVE) SUPPORTS HISTORICALLY BLACK COLLEGES AND UNIVERSITIES (HBCUS), HISPANIC-SERVING INSTITUTIONS (HSIS), AND TRIBAL COLLEGES AND UNIVERSITIES (TCUS) TO STRENGTHEN THEIR INSTITUTIONAL RESPONSE TO DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING ON CAMPUS. THE CSC INITIATIVE FOCUSES ON BUILDING THE CAPACITY OF THESE INSTITUTIONS TO ESTABLISH CULTURALLY RELEVANT STRATEGIES TO ADDRESS DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING, INCLUDING THE DEVELOPMENT OF EFFECTIVE RESPONSE PROTOCOLS AND PREVENTION PROGRAMMING. TEXAS SOUTHERN UNIVERSITY IS A PUBLIC, FOUR-YEAR, HISTORICALLY BLACK COLLEGE AND UNIVERSITY (HBCU) LOCATED IN HOUSTON, TX. WITH THIS NEW AWARD, TEXAS SOUTHERN UNIVERSITY, IN COLLABORATION WITH ITS CAMPUS PARTNERS, WILL CREATE CULTURALLY SPECIFIC STRATEGIES TAILORED TO BLACK STUDENTS AND OTHER UNDERSERVED POPULATIONS, AND WORK WITH THE DESIGNATED CAMPUS TECHNICAL ASSISTANCE PROVIDER TO: 1) BUILD THE CAPACITY OF THE INSTITUTION TO DEVELOP A CULTURALLY SPECIFIC, COORDINATED COMMUNITY RESPONSE TO ADDRESS DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING BY SECURING RELEVANT PARTNERSHIPS, CONDUCTING TRAININGS, AND DEVELOPING RESOURCES TAILORED TO THE CAMPUS COMMUNITY; 2) DEVELOP AN ACTION PLAN TO OUTLINE KEY STRATEGIES NECESSARY TO ESTABLISH A COORDINATED COMMUNITY RESPONSE; AND 3) ESTABLISH A COORDINATED COMMUNITY RESPONSE TEAM THAT WILL OVERSEE AND IMPLEMENT PROJECT ACTIVITIES.
assistance · Last action 2024-09-23
$500,000
Department of Health and Human Services
MECHANISM OF IOP-LOWERING EFFECTS OF HYDROGEN SULFIDE - PROJECT SUMMARY/ABSTRACT IN PRIMARY OPEN ANGLE GLAUCOMA, ELEVATED INTRAOCULAR PRESSURE (IOP) IS ASSOCIATED WITH ABNORMALLY INCREASED RESISTANCE TO AQUEOUS HUMOR (AH) OUTFLOW. DUE TO THE COMPLEX PATHOGENESIS OF GLAUCOMA, THE EXACT MECHANISM FOR INCREASED RESISTANCE TO AH OUTFLOW AND CHANGES IN VASCULAR FUNCTION IS YET TO BE FULLY DETERMINED. EVIDENCE OF THE PRESENCE OF A FUNCTIONAL TRANS-SULFURATION PATHWAY IN MAMMALIAN TISSUES HAS STIMULATED A SURGE OF INTEREST IN THE BIOLOGICAL SIGNIFICANCE AND ROLE OF HYDROGEN SULFIDE (H2S) IN OCULAR FUNCTION AND DISEASE. IN A PREVIOUS STUDY WE SHOWED EVIDENCE THAT H2S (USING H2S-RELEASING COMPOUNDS AS TOOLS) CAN LOWER IOP IN NORMOTENSIVE RABBITS. FURTHERMORE, WE REPORTED THAT H2S CAN ENHANCE AQUEOUS HUMOR OUTFLOW, AN EFFECT THAT IS MEDIATED VIA THE CONVENTIONAL PATHWAY. HOWEVER, THE EXACT MECHANISM OF ACTION OF H2S ON ELEVATED IOP AND AQUEOUS HUMOR DYNAMICS IS UNCLEAR. THE GOAL OF THE PRESENT PROPOSAL IS TO UNDERSTAND THE ROLE OF H2S IN THE PATHWAY AND PROCESSES INVOLVED IN THE REGULATION OF IOP IN GLAUCOMA. SPECIFICALLY, WE WILL EVALUATE THE PHYSIOLOGICAL/PHARMACOLOGICAL ACTION OF H2S (USING H2S-RELEASING COMPOUNDS) ON AN EXPERIMENTALLY-INDUCED ANIMAL MODEL OF GLAUCOMA AND WILL ALSO DETERMINE THE ROLE OF THE ENDOGENOUS PATHWAY FOR THE BIOSYNTHESIS OF H2S IN THE MAINTENANCE OF IOP IN THIS MODEL. FURTHERMORE, WE WILL INVESTIGATE THE CELLULAR MECHANISM/S OF ACTION OF EXOGENOUSLY-ADMINISTERED H2S AND ENDOGENOUSLY-PRODUCED H2S ON PATHWAYS INVOLVED IN THE OUTFLOW OF IOP AND NEURODEGENERATIVE CHANGES IN GLAUCOMA. IN SUMMARY, STUDIES DESIGNED IN THE PRESENT PROPOSAL WILL ADDRESS THE FOLLOWING QUESTIONS: I) WHAT IS THE EFFECT OF TOPICALLY INSTILLED H2S (USING H2S-RELEASING COMPOUNDS AS GAS DONORS) ON ELEVATED IOP? (II) ARE BIOSYNTHETIC ENZYMES FOR H2S PRODUCTION (CBS, CSE, 3MST) INVOLVED IN THE RELEASE AND/OR AVAILABILITY OF H2S IN THE CILIARY ARTERY, CILIARY EPITHELIUM, IRIS, TM AND NEURAL RETINA IN CONTROL AND EXPERIMENTAL ANIMALS WITH GLAUCOMA? (III) DOES THE CONCENTRATION OF H2S IN TISSUES (CILIARY ARTERY, CILIARY EPITHELIUM, IRIS, TM AND NEURAL RETINA) CORRELATE WITH PROTEIN/MRNA EXPRESSION LEVELS OF BIOSYNTHETIC ENZYMES (CBS, CSE AND 3MST) IN CONTROL AND EXPERIMENTAL ANIMALS WITH GLAUCOMA? (IV) DOES THE PATHWAY LEADING TO H2S PRODUCTION ALTERED BY ELEVATED PRESSURE IN THE TM USING THE HUMAN ANTERIOR SEGMENT ORGAN CULTURE MODEL? (V) DOES THE IOP-LOWERING ACTION OF H2S (ADMINISTERED AS H2S-RELEASING COMPOUNDS) INVOLVE CHANGES IN TM MORPHOLOGY AND MMP-INITIATED ECM TURNOVER? (VI) DOES THE H2S-MEDIATED CHANGES IN IOP MITIGATE SOME OF THE NEURODEGENERATIVE CHANGES OBSERVED IN GLAUCOMA? WHAT ARE THE MECHANISM/S INVOLVED? WE ANTICIPATE THAT DATA OBTAINED FROM THE PRESENT STUDY MAY ALSO REVEAL A NOVEL ROLE FOR H2S IN THE PATHOPHYSIOLOGY AND/OR PHARMACOLOGY OF THE ANTERIOR UVEA AND POSTERIOR SEGMENT OF THE EYE.
assistance · Last action 2026-04-08
$438,325
Department of Education
CAMPUS BASED-FSEOG
assistance · Last action 2023-03-13
$431,437
National Science Foundation
TARGETED INFUSION PROJECT: ADVANCING BASIC SCIENCE RESEARCH AND UNDERGRADUATE EDUCATION IN COMPUTER VISION -THE HISTORICALLY BLACK COLLEGES AND UNIVERSITIES (HBCU) UNDERGRADUATE PROGRAM?S TARGETED INFUSION PROJECTS AIM TO SUPPORT RESEARCH AND EDUCATIONAL PROJECTS TO IMPROVE THE SUCCESS OF HBCU STUDENTS IN SCIENCE, TECHNOLOGY, ENGINEERING OR MATHEMATICS (STEM) GRADUATE PROGRAMS AND CAREERS. COMPUTER VISION IS AN IMPORTANT SUBFIELD OF ARTIFICIAL INTELLIGENCE, AND IT DEALS WITH DEVELOPING AND ANALYZING ALGORITHMS THAT CAN EXTRACT USEFUL INFORMATION FROM IMAGES. ITS ORIGINS CAN BE TRACED TO RESEARCH ACTIVITIES IN THE 1960S AIMING TO INVENT MACHINES THAT IMITATE HUMAN COGNITIVE FUNCTIONS IN DIRECTLY OBSERVING INFORMATION FROM PHOTOS. SINCE COMPUTER VISION IS INSTRUMENTAL IN SCIENCE AND TECHNOLOGY, THIS TARGETED INFUSION PROJECT FOCUSES ON ADVANCING THIS FIELD BY IMPROVING CURRICULUM AND ESTABLISHING NEW EDUCATIONAL AND RESEARCH INFRASTRUCTURES AT TEXAS SOUTHERN UNIVERSITY. LEARNING COMPUTER VISION THEORIES CAN BE CHALLENGING FOR MOST UNDERGRADUATE STUDENTS AS THESE THEORIES OFTEN INVOLVE HIGH LEVELS OF MATHEMATICAL RELATIONS. A COMMON WAY OF TEACHING COMPUTER VISION IS TO PRESENT THEORETICAL FOUNDATIONS THAT ARE FOLLOWED BY EXAMPLES TO HIGHLIGHT THE SIGNIFICANCE OF THESE THEORIES. HOWEVER, STUDENTS MAY HAVE DIFFICULTIES FOLLOWING LENGTHY MATHEMATICAL DERIVATIONS AND UNDERSTANDING SPECIFIC RATIONALES OF THESE DERIVATIONS WITHOUT SEEING EXAMPLES THAT CLARIFY THE ROLE OF MAJOR COMPONENTS. IN ORDER TO IMPROVE TEACHING METHODOLOGY IN COMPUTER VISION, THIS PROJECT AIMS TO IMPLEMENT AND INVESTIGATE TWO TEACHING MODELS, BASED ON THEORETICAL AND HANDS-ON EXPOSURE TO COMPUTER VISION. THE OTHER AIMS OF THIS PROJECT ARE TO CREATE A COMPUTER VISION CERTIFICATION PROGRAM INCLUDING A NEW COURSE ON THIS FIELD AT TEXAS SOUTHERN UNIVERSITY, TO CREATE A COMPUTER VISION RESEARCH PROGRAM TO ENGAGE SENIOR YEAR UNDERGRADUATE STUDENTS IN RESEARCH, AND TO PROVIDE EDUCATIONAL AND RESEARCH OPPORTUNITIES TO HIGH SCHOOL STUDENTS IN COMPUTER VISION THROUGH SUMMER BOOT CAMPS. TO THIS END, LEARNING MODULES WITH THEORETICAL AND LABORATORY COMPONENTS TO STRENGTHEN STUDENTS' KNOWLEDGE AND PRACTICAL SKILLS, COMPUTATIONAL RESOURCES, AND CONTINUOUS SUPERVISION FOR THEIR RESEARCH PROJECTS ARE PROVIDED. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
assistance · Last action 2022-08-08
$399,924
National Science Foundation
TARGETED INFUSION PROJECT: CREATION OF AN ENVIRONMENTAL SCIENCE MINOR PROGRAM FOR STEM SUCCESS
assistance · Last action 2021-08-31
$396,230
Smithsonian Institution
HBCU HISTORY AND CULTURE ACCESS CONSORTIUM PILOT INITIATIVE
contract · Last action 2024-10-01
$316,268
National Science Foundation
RESEARCH INITIATION AWARD: NON-APOPTOTIC FUNCTIONS FOR FAS-ASSOCIATED DEATH DOMAIN (FADD) IN OSTEOSAROCMA
assistance · Last action 2025-05-05
$294,832
Department of Education
TRIO-STUDENT SUPPORT SERVICES (CLASSIC)
assistance · Last action 2025-07-04
$272,364
Department of Education
TRIO-STUDENT SUPPORT SERVICES (STEM)
assistance · Last action 2025-07-03
$272,364
National Science Foundation
CATALYST PROJECT: RESEARCH EXPERIENCES TO ACCELERATE CHEMISTRY -CATALYST PROJECTS PROVIDE SUPPORT FOR HISTORICALLY BLACK COLLEGES AND UNIVERSITIES (HBCU) TO WORK TOWARDS ESTABLISHING RESEARCH CAPACITY OF FACULTY TO STRENGTHEN SCIENCE, TECHNOLOGY, ENGINEERING AND MATHEMATICS UNDERGRADUATE EDUCATION AND RESEARCH. IT IS EXPECTED THAT THE AWARD WILL FURTHER THE FACULTY MEMBER'S RESEARCH CAPABILITY, IMPROVE RESEARCH AND TEACHING AT THE INSTITUTION, AND INVOLVE UNDERGRADUATE STUDENTS IN RESEARCH EXPERIENCES. TEXAS SOUTHERN UNIVERSITY SEEKS TO IMPLEMENT A PROJECT-BASED LEARNING MODEL IN THE CHEMISTRY II LABORATORY COURSE TO PROVIDE FRESHMEN STUDENTS CLASSROOM-BASED RESEARCH EXPERIENCES, AS WELL AS PROVIDE SUPPORT STUDENTS IN A MENTORED SUMMER RESEARCH PROGRAM. AS A RESULT OF THEIR PARTICIPATION, IT IS ANTICIPATED THAT STUDENTS WOULD ACQUIRE 21ST CENTURY COMPETENCIES NEEDED FOR CAREERS IN STEM. THE PROJECT AT TEXAS SOUTHERN UNIVERSITY SEEKS TO POSITIVELY IMPACT STUDENT ATTITUDES TOWARDS STEM EDUCATION AND INCREASE STUDENT PERSISTENCE IN STEM DISCIPLINES. THE OBJECTIVES ARE TO 1) TO REFORM THE GENERAL CHEMISTRY LABORATORY COURSE USING PROJECT-BASED LEARNING METHODS FOR FIRST YEAR UNDERGRADUATE STUDENTS; AND 2) TO IMMERSE UNDERGRADUATE STUDENTS FROM UNDERREPRESENTED GROUPS ANNUALLY IN AN INTENSIVE 6-WEEK SUMMER ENHANCED LEARNING AND RESEARCH PROGRAM. STUDENTS WILL BE DIRECTED THROUGH THE ANALYTICAL PROCESS BY USING THE SCAFFOLD METHODOLOGY, IN WHICH THEY FORMULATE A QUESTION, CONSIDER SAMPLING, PREPARE SAMPLES FOR ANALYSIS, ANALYZE THE SAMPLE, REPORT DATA, EVALUATE RESULTS, DRAW CONCLUSIONS, AND DETERMINE THE NEEDS FOR FUTURE RESEARCH. THE PROJECT OUTCOMES, GUIDED BY AN EXTERNAL EVALUATION, ARE EXPECTED TO CONTRIBUTE TO UNDERSTANDING NOT ONLY THE SUCCESS OF THE PROGRAM, BUT ADD TO THE KNOWLEDGE BASE OF THE PREPARATION OF UNDERREPRESENTED GROUPS USING PROJECT-BASED LEARNING METHODS, RETENTION OF STUDENTS IN STEM DISCIPLINES, AND STUDENT PURSUIT OF ADVANCED DEGREES AND CAREERS IN STEM. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.
assistance · Last action 2023-08-24
$200,000
National Science Foundation
COLLABORATIVE RESEARCH:CISE-MSI:DP:CNS:ENABLING ON-DEMAND AND FLEXIBLE MOBILE EDGE COMPUTING WITH INTEGRATED AERIAL-GROUND VEHICLES -THE RAPID PROLIFERATION OF MOBILE AND INTERNET-OF-THINGS DEVICES HAS REVOLUTIONIZED VARIOUS ASPECTS OF OUR LIVES. HOWEVER, THE ENORMOUS AMOUNT OF DATA GENERATED BY THESE DEVICES POSES SIGNIFICANT CHALLENGES FOR WIRELESS-COMMUNICATION INFRASTRUCTURE, WHICH HAS LIMITED RADIO SPECTRUM. ADDITIONALLY, MANY EMERGING APPLICATIONS REQUIRE LOW-LATENCY AND COMPUTATION-INTENSIVE PROCESSING, MAKING THE TRADITIONAL CLOUD-CENTRIC APPROACH INADEQUATE. TO ADDRESS THESE CHALLENGES, THIS PROJECT PROPOSES AN INNOVATIVE SOLUTION CALLED AERIAL-GROUND INTELLIGENT VEHICULAR EDGE (AGILE) WHICH LEVERAGES THE CAPABILITIES OF AERIAL AND GROUND VEHICLES WITH ARTIFICIAL-INTELLIGENCE-PROCESSING CAPABILITIES TO CREATE AN ON-DEMAND, FLEXIBLE, AND COST-EFFECTIVE MOBILE-EDGE-COMPUTING (MEC) SYSTEM. AGILE AIMS TO PROVIDE UBIQUITOUS AND LOW-LATENCY COMPUTING SERVICES TO SUPPORT MASSIVE CONNECTED DEVICES AND ENABLE EFFICIENT DATA PROCESSING. THE PROJECT FOCUSES ON DESIGNING THE AGILE ARCHITECTURE, WHICH INTEGRATES AERIAL AND GROUND VEHICLES INTO A 3D NETWORK FOR INTELLIGENT MEC SERVICE PROVISIONING. FIRSTLY, THE RESEARCH INVESTIGATES COLLABORATIVE TRAINING SCHEMES BETWEEN UNMANNED AERIAL VEHICLES (UAVS) AND GROUND VEHICLES TO ENABLE FAST AND ENERGY-EFFICIENT FEDERATED LEARNING FOR INTELLIGENT MEC SERVICES. SECONDLY, THE PROJECT ADDRESSES THE COUPLING ISSUE OF UAV POSITIONING, COMMUNICATION, AND COMPUTING-RESOURCE ALLOCATION, OPTIMIZING THEM FOR ON-DEMAND MEC SERVICE PROVISIONING. FINALLY, DYNAMIC UAV MOVEMENT AND RESOURCE-RECONFIGURATION SCHEMES ARE DEVELOPED TO ADAPTIVELY MEET USER DEMAND AND TO ACHIEVE FLEXIBLE MEC SERVICE PROVISIONING IN THE PRESENCE OF VARYING GROUND-VEHICLE RESOURCES. THIS PROJECT WILL STRENGTHEN THE EXISTING RESEARCH COLLABORATIONS AMONG THE THREE PARTICIPATING MINORITY-SERVING INSTITUTIONS, WHILE FOSTERING RESEARCH INVOLVEMENT OF AFRICAN AMERICAN/BLACK, HISPANIC, AND WOMEN UNDERGRADUATE AND/OR GRADUATE STUDENTS WITH THE KNOWLEDGE AND SKILLS TO CONTRIBUTE TO THE FIELDS OF MEC AND ARTIFICIAL INTELLIGENCE. THOSE UNDERSERVED STUDENTS WILL BENEFIT FROM THIS PROJECT THROUGH RESEARCH PROJECTS, CLASSROOM TEACHING, AND SENIOR-DESIGN PROJECTS. SUCH PARTICIPATION WILL HELP ALL INSTITUTES IN IMPROVING UNDERREPRESENTED STUDENTS' RETENTION RATES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
assistance · Last action 2023-07-14
$200,000
Department of Health and Human Services
IMMUNOGLOBULIN REPERTOIRE ANALYSIS OF TUMOR INFILTRATING B CELLS IN A METASTATIC HER2 POSITIVE BREAST CANCER MOUSE MODEL - BREAST CANCER (BC) IS THE MOST COMMONLY DIAGNOSED CANCER AND ONE OF THE LEADING CAUSES OF CANCER-RELATED DEATH WORLDWIDE. HER2 POSITIVE (HER2+) BC, PRESENT IN APPROXIMATELY 30% OF BC CASES, IS CHARACTERIZED BY ITS AGGRESSIVE PROGRESSION AND HIGH LIKELIHOOD OF METASTASIS. PATIENT SURVIVAL SIGNIFICANTLY DECLINES ONCE THE CANCER BECOMES RESISTANT TO STANDARD TREATMENTS OR SPREADS. MUTATIONS IN THE TUMOR SUPPRESSOR GENE P53 ARE OBSERVED IN 50% TO 90% OF HER2-POSITIVE BCS AND ARE STRONGLY CORRELATED WITH POORER SURVIVAL OUTCOMES. MEANWHILE, EMERGING EVIDENCE SUGGESTS THAT IMMUNOGLOBULINS (IGS) PRODUCED BY TUMOR-INFILTRATING B CELLS (TIL-BS) RECOGNIZE AND RESPOND TO TUMOR ANTIGENS AND MAY PLAY A TUMOR-SUPPRESSIVE ROLE. OUR PRELIMINARY DATA INDICATE THAT HER2+ BC PATIENTS WITH HIGHER LEVELS OF IGS FROM THE TIL-BS EXPERIENCE LONGER SURVIVAL COMPARED TO THOSE WITH FEWER IGS. ADDITIONALLY, IN A HER2+ BC MOUSE MODEL, THE NUMBER OF IGS WITHIN TUMORS IS SIGNIFICANTLY LOWER THAN IN THE PRECANCEROUS MAMMARY GLAND, AND THIS NUMBER DECREASES FURTHER WHEN THE CANCER METASTASIZES. THE COMPREHENSIVE STUDY OF THE IG REPERTOIRE IN THE CANCER GENOME ATLAS DATASETS LED TO THE DISCOVERY OF PUBLIC IGS, WHICH SHARE IDENTICAL CDR3 SEQUENCES AND V/J GENE USAGE ACROSS MULTIPLE PATIENTS AND MAY POSSESS POTENTIAL ANTI-TUMOR ACTIVITY. THE GOAL OF THIS PROPOSED STUDY IS TO INVESTIGATE THE IG REPERTOIRES FROM THE TIL-BS AND THE FUNCTION OF THE PUBLIC IGS IN A METASTATIC HER2+ BC MOUSE MODEL. WE HYPOTHESIZE THAT NONMETASTATIC HER2+ BC CONTAINS DISTINCT PUBLIC IGS PRODUCED BY THE TIL-BS, WHICH POSSESS ANTIMETASTATIC FUNCTION. BOTH METASTATIC AND NONMETASTATIC PRIMARY TUMORS FROM THE HER2+ MOUSE MODEL HARBORING WILD-TYPE OR MUTANT P53 WILL BE SUBJECTED TO IG REPERTOIRE ANALYSIS. THE PUBLIC IGS WILL BE SYNTHESIZED, SCREENED FOR POTENTIAL ANTIGENS, AND ASSESSED FOR THEIR TUMOR-BINDING ACTIVITIES. LASTLY, SELECTED PUBLIC IGS WILL BE TESTED FOR TUMOR SUPPRESSIVE EFFICACY BOTH IN VITRO AND IN VIVO. THIS PROJECT HAS THE POTENTIAL TO SIGNIFICANTLY ADVANCE OUR UNDERSTANDING OF HER2+ BC BIOLOGY AND CONTRIBUTE TO THE DEVELOPMENT OF NOVEL THERAPEUTIC STRATEGIES. ADDITIONALLY, THE PROJECT INCORPORATES A COMPREHENSIVE STRATEGY TO INVOLVE BOTH GRADUATE AND UNDERGRADUATE STUDENTS IN BIOMEDICAL RESEARCH, PROVIDING THEM WITH PRACTICAL RESEARCH EXPERIENCE AND PROFESSIONAL GROWTH OPPORTUNITIES. STUDENTS WILL UNDERGO THOROUGH TRAINING IN EXPERIMENTAL METHODS, INTERDISCIPLINARY TEAMWORK, AND CRITICAL THINKING, EQUIPPING THEM FOR FUTURE STUDIES AND CAREERS IN CANCER RESEARCH. THIS INITIATIVE AIMS TO NURTURE A NEW GENERATION OF BIOMEDICAL RESEARCHERS, EMPOWERING THEM WITH THE EXPERTISE TO MAKE MEANINGFUL CONTRIBUTIONS TO THE FIELD OF CANCER RESEARCH.
assistance · Last action 2025-09-03
$170,127

Federal contract dollars to this establishment. Primary NAICS: 712110 - MUSEUMS. Last action: 2024-10-01. Source: USAspending.gov, net obligations. Recipient address is the SAM registration / HQ address, not necessarily the worksite.

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