Marquette University

GRANT PROGRAM

MARQUETTE UNIVERSITY-DORMS

IN DEFENSE OF WATER STRATEGIES AND TECHNOLOGIES TO ENHANCE THE NATIONS WATER RESILIENCY

FUNCTIONAL TESTING OF KLF7 IN SPINAL CORD INJURY: AN OPTOGENETIC APPROACH

LODGING FOR USSS PERSONNEL AT THE DEMOCRATIC NATIONAL CONVENTION

NURSING WORKFORCE DIVERSITY

MARQUETTE UNIVERSITY STUDENT SUPPORT SERVICES PROGRAM 2020-2025

MARQUETTE UNIVERSITY UPWARD BOUND - CLASSIC

INCREASING AND DIVERSIFYING WISCONSIN SCHOOL COUNSELORS IN HIGH-NEED LEAS THROUGH TRADITIONAL AND ACCELERATED PROGRAMS

DE-EE0009872 TITLED DEVELOPMENT OF A FLEX FUEL MIXING CONTROLLED COMBUSTION SYSTEM FOR GASOLINE ETHANOL BLENDS ENABLED BY PRECHAMBER IGNITION. NEW AWARD TO MARQUETTE UNIVERSITY.

CAMPUS BASED-FWS

HIGH-INTENSITY, DYNAMIC-STABILITY GAIT TRAINING IN PEOPLE WITH MULTIPLE SCLEROSIS - PROJECT SUMMARY THE GOAL OF THIS PHASE I/II MULTICENTER CLINICAL TRIAL IS TO IMPROVE WALKING FUNCTION, DYNAMIC STABILITY, AND COMMUNITY MOBILITY IN PEOPLE WITH MULTIPLE SCLEROSIS (MS) USING A NOVEL COMBINATION OF HIGH-INTENSITY TRAINING AND AN ENVIRONMENT THAT CHALLENGES DYNAMIC BALANCE. THERE ARE TWO CRITICAL ELEMENTS OF THIS PROPOSAL: 1) BALANCE PERTURBATIONS APPLIED DURING TREADMILL WALKING WILL ALLOW PARTICIPANTS TO DEVELOP NEUROMUSCULAR STRATEGIES TO MAINTAIN UPRIGHT POSTURE, WHICH WILL BE REFINED AND ENHANCED WITH REPEATED PRACTICE, AND 2) PATIENTS WHO ENGAGE IN HIGH-INTENSITY TRAINING WILL IMPROVE THEIR NEUROMUSCULAR AND CARDIORESPIRATORY CAPACITY TO FACILITATE THE ABILITY TO WALK FASTER AND FURTHER. INDEED, PATIENTS WITH MILD OR MODERATE MS PRESENT WITH ALTERED LOCOMOTOR AND POSTURAL CONTROL, AND THIS 2X2 FACTORIAL DESIGN WILL DELINEATE THE INDIVIDUAL AND COMBINED EFFECTS OF REPEATED EXPOSURE TO POSTURAL PERTURBATIONS DURING WALKING AND HIGH-INTENSITY EXERCISE THAT MAY ENHANCE LOCOMOTOR AND BALANCE CONTROL IN BOTH LABORATORY CONDITIONS AND IN THE REAL-WORLD, WHERE THE LOCOMOTOR AND POSTURAL DEMANDS ARE SUBSTANTIAL. THIS STUDY IS PREDICATED ON THE PREVIOUS EXPERIENCE OF THE INVESTIGATORS WITH HIGH-INTENSITY TRAINING IN PATIENTS WITH OTHER NEUROLOGICAL DISORDERS AND PROMISING RESULTS OF A PILOT STUDY DEMONSTRATING FEASIBILITY OF DYNAMIC BALANCE TREADMILL TRAINING IN PEOPLE WITH MS. THE PRESENT PROJECT WILL ATTEMPT TO DELINEATE CHANGES IN CLINICAL AND LABORATORY MEASURES OF LOCOMOTOR CAPACITY FOLLOWING WALKING- SPECIFIC EXERCISE TRAINING AT HIGH VS LOW INTENSITY AND WITH OR WITHOUT POSTURAL PERTURBATIONS DURING TREADMILL STEPPING (AIM 1). AIM 2 WILL DEMONSTRATE THE RELATIVE EFFICACY OF THESE STRATEGIES ON DYNAMIC POSTURAL CONTROL (I.E., BALANCE) AND RELATE IMPROVEMENTS IN THE RESPONSE TO PERTURBATIONS TO SECONDARY MEASURES OF COMMUNITY FALLS. FINALLY, AIM 3 WILL DELINEATE CHANGES IN COMMUNITY MOBILITY AND PARTICIPATION FOLLOWING THESE VARIOUS EXERCISE PARADIGMS. WE SUGGEST THAT HIGH-INTENSITY LOCOMOTOR TRAINING WITH POSTURAL PERTURBATIONS WILL ELICIT THE LARGEST CHANGES IN BOTH LOCOMOTOR AND BALANCE OUTCOMES, AND THESE COMBINED GAINS WILL BOOST PHYSICAL ACTIVITY IN THE COMMUNITY SETTING LEADING TO IMPROVED QUALITY OF LIFE.

PACAP-DEPENDENT COORDINATION OF GLUTAMATE SIGNALING BETWEEN NEURONS AND ASTROCYTES

ISCHEMIC CONDITIONING AND IMPROVED MOTOR FUNCTION POST STROKE

GERIATRICS WORKFORCE ENHANCEMENT PROGRAM

ENHANCEMENTS FOR A CAREER-CHANGE PATHWAY FOR NON-COMPUTING MAJORS -THIS PROJECT WILL CONTRIBUTE TO THE NATIONAL NEED FOR WELL-EDUCATED SCIENTISTS, MATHEMATICIANS, ENGINEERS, AND TECHNICIANS BY SUPPORTING THE RETENTION AND GRADUATION OF HIGH-ACHIEVING, LOW-INCOME STUDENTS WITH DEMONSTRATED FINANCIAL NEED AT MARQUETTE UNIVERSITY. OVER ITS SIX-YEAR DURATION, THIS TRACK 2 PROJECT WILL FUND SCHOLARSHIPS TO 35 UNIQUE FULL-TIME STUDENTS WHO ARE PURSUING GRADUATE DEGREES IN COMPUTER AND INFORMATION SCIENCE/DATA SCIENCE. POST-BACCALAUREATE STUDENTS WILL BE GIVEN THE OPPORTUNITY TO FORGE A CAREER PATHWAY INTO A PROFESSIONAL MASTER OF SCIENCE (MS) IN COMPUTER AND INFORMATION SCIENCE/DATA SCIENCE PROGRAM AND WILL RECEIVE SCHOLARSHIPS, ON AVERAGE, IN FIVE ACADEMIC TERMS (OUT OF A TOTAL OF SIX TERMS). SPECIFIC PROJECT ACTIVITIES INCLUDE (I) DEVELOPMENT, DELIVERY, AND ASSESSMENT OF IMPACTFUL DISTANCE LEARNING ADAPTATIONS TO THE FOUNDATIONS OF COMPUTING BRIDGE COURSE AS WELL AS CO-CURRICULAR SUPPORTS FOR STUDENTS SEEKING A CAREER CHANGE; (II) INVESTIGATION OF FACTORS INFLUENCING THE DEVELOPMENT OF COMPUTING PROFESSIONAL IDENTITY IN POST-BACCALAUREATE CAREER-CHANGING INDIVIDUALS; (III) DISSEMINATION OF FINDINGS RE-CURRICULAR AND CO-CURRICULAR ACTIVITIES THAT PROMOTE SUCCESSFUL CONVERSION INTO COMPUTING FOR STUDENTS WHO HAVE LITTLE PRIOR ACADEMIC TRAINING IN COMPUTING. A UNIQUE FEATURE OF MARQUETTE UNIVERSITY'S MASTER OF SCIENCE IN COMPUTER AND INFORMATION SCIENCE PROGRAM IS THE PROVISION OF A MODEL FOR STUDENTS TO CROSS OVER FROM NON-STEM UNDERGRADUATE DEGREES TO HIGH DEMAND, WELL-PAID JOBS IN COMPUTING. AN IMPORTANT BROADER IMPACT OF THE PROJECT IS THE DIVERSIFICATION OF THE POOL OF QUALIFIED COMPUTING PROFESSIONALS THROUGH INCLUSION OF ACADEMICALLY TALENTED LOW-INCOME STUDENTS. THE INTELLECTUAL MERIT OF THE PROJECT IS THE GENERATION OF NEW KNOWLEDGE ON OPTIMAL BRIDGE COURSE CONTENT AND DELIVERY AS WELL AS PROGRAM ACADEMIC SUPPORTS FOR STUDENTS WHO HAVE LITTLE PRIOR ACADEMIC TRAINING IN COMPUTING. THE OVERALL GOAL OF THIS PROJECT IS TO SIGNIFICANTLY INCREASE STEM DEGREE COMPLETION OF LOW-INCOME, HIGH-ACHIEVING UNDERGRADUATES WITH DEMONSTRATED FINANCIAL NEED. SPECIFICALLY, THE PROJECT WILL UPDATE AN ONLINE COMPUTER SCIENCE BRIDGE COURSE TO EXPEDITE A POST-BACCALAUREATE CAREER PATHWAY INTO A PROFESSIONAL MASTER OF SCIENCE IN COMPUTER AND INFORMATION SCIENCE PROGRAM. THE UNDERLYING RATIONALE FOR THE PROJECT IS THE NEED FOR A MECHANISM FOR STUDENTS WITH NON-COMPUTING AND NON-STEM UNDERGRADUATE DEGREES TO ACQUIRE COMPETENCIES IN COMPUTING THAT CAN LEAD TO A MASTER OF SCIENCE DEGREE IN COMPUTER AND INFORMATION SCIENCE. THERE IS EVIDENCE OF GROWING DEMAND FOR THIS TYPE OF BRIDGE COURSE AMONG A BROAD ADULT POPULATION, FURTHERMORE, THE CAREER CHANGE OPPORTUNITY WILL HAVE A POSITIVE EFFECT ON THE LOCAL AND REGIONAL WORKFORCE THROUGH PROVISION OF TRAINING NEEDED TO FULFILL CURRENT EDUCATION AND WORKFORCE DEVELOPMENT NEEDS. THE PROJECT WILL ADVANCE DEVELOPMENT OF THE BRIDGE COURSEWORK THAT PROVIDES ACCELERATED COVERAGE OF BACKGROUND CONCEPTS FOR THE SPECIFIC NEEDS OF CAREER CHANGING INDIVIDUALS. KNOWLEDGE GENERATION IS EXPECTED REGARDING THE DEVELOPMENT OF COMPUTING PROFESSIONAL IDENTITY IN POST-BACCALAUREATE, CAREER-CHANGING INDIVIDUALS. FOR FORMATIVE AND SUMMATIVE EVALUATION OF THE IMPACT OF THE BRIDGE COURSE, QUANTITATIVE DATA WILL BE COLLECTED BY THE EVALUATION TEAM THROUGH SURVEYS, WHILE QUALITATIVE DATA WILL BE COLLECTED THROUGH ONE-ON-ONE OR GROUP INTERVIEWS. DISSEMINATION OF FINDINGS WILL OCCUR THROUGH JOURNAL ARTICLES, CONFERENCE PAPERS AND POSTERS AT COMPUTER SCIENCE EDUCATION CONFERENCES, REGIONAL PROFESSIONAL ORGANIZATIONS AS WELL AS COMMUNITY STAKEHOLDERS, BUSINESSES AND ORGANIZATIONS ACTIVELY INVOLVED WITH STUDENT PRACTICUMS. THIS PROJECT IS FUNDED BY NSF'S SCHOLARSHIPS IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS PROGRAM, WHICH SEEKS TO INCREASE THE NUMBER OF LOW-INCOME ACADEMICALLY TALENTED STUDENTS WITH DEMONSTRATED FINANCIAL NEED WHO EARN DEGREES IN STEM FIELDS. IT ALSO AIMS TO IMPROVE THE EDUCATION OF FUTURE STEM WORKERS, AND TO GENERATE KNOWLEDGE ABOUT ACADEMIC SUCCESS, RETENTION, TRANSFER, GRADUATION, AND ACADEMIC/CAREER PATHWAYS OF LOW-INCOME STUDENTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

AVERSION SIGNALS IN THE REWARD SYSTEM

MECHANISMS OF FATIGABILITY AND THE PROTECTIVE EFFECTS OF EXERCISE IN PEOPLE WITH DIABETES - ABSTRACT PRE-DIABETES (PRE-D) IS CHARACTERIZED BY ELEVATED GLYCATED HEMOGLOBIN AND PLASMA GLUCOSE AND IS A CLINICAL PRECURSOR TO TYPE 2 DIABETES MELLITUS (T2D). PRE-D CURRENTLY AFFECTS ~90 MILLION AMERICANS. BOTH PRE-D AND T2D ARE HIGHLY ASSOCIATED WITH CARDIOVASCULAR DISEASE AND AMONG THE TOP FIVE CAUSES OF MORTALITY WORLDWIDE. EXERCISE IS THE CORNERSTONE OF MANAGEMENT AND IS MOST EFFICACIOUS DURING THE PRE-D STAGE WHEN GLYCEMIA IS BELOW THE DIABETIC THRESHOLD. HOWEVER, EXCESSIVE FATIGABILITY DURING EXERCISE (I.E., EXERCISE INDUCED REDUCTIONS IN FORCE OR POWER OF THE LIMB MUSCLES) LIMITS EXERCISE PERFORMANCE IN PEOPLE WITH PRE-D. OUR LABORATORY DEMONSTRATED THAT (1) ACROSS THE DIABETIC SPECTRUM, PEOPLE WITH PRE-D AND T2D HAVE GREATER FATIGABILITY OF LIMB MUSCLES THAN CONTROLS DUE TO MECHANISMS WITHIN THE MUSCLE, AND (2) FATIGABILITY IN PEOPLE WITH T2D WAS ASSOCIATED WITH A REDUCED BLOOD FLOW TO THE EXERCISING MUSCLE. IT IS UNKNOWN, HOWEVER, IF PEOPLE WITH PRE-D HAVE IMPAIRED VASCULAR FUNCTION AND OXYGEN DELIVERY THAT LEADS TO AN INCREASED FATIGABILITY. OUR CENTRAL HYPOTHESIS IS THAT IMPAIRED VASCULAR FUNCTION IMPEDES BLOOD FLOW AND BLUNTS SUBSEQUENT OXYGEN DELIVERY TO SKELETAL MUSCLE DURING EXERCISE, RESULTING IN EXCESSIVE FATIGABILITY OF LIMB MUSCLES IN PEOPLE WITH PRE-D. A UNIQUE AND TRANSLATIONAL ASPECT OF THIS PROPOSAL IS THE QUANTIFICATION OF THE VASCULAR RESPONSES (MACRO- AND MICRO-VASCULATURE) TO FATIGUING EXERCISE AND EXERCISING TRAINING AT DIFFERENT SITES ALONG THE VASCULAR TREE, INCLUDING, IN FEED ARTERIES (DOPPLER ULTRASONOGRAPHY), ISOLATED SKELETAL MUSCLE ARTERIOLES (EXTRACTED FROM MUSCLE BIOPSY), CAPILLARY PERFUSION (NEAR INFRARED SPECTROSCOPY, NIRS) AND CAPILLARY DENSITY (FROM MUSCLE BIOPSIES). AIM 1 WILL DETERMINE IF VASCULAR DYSFUNCTION IS A MECHANISM FOR EXCESSIVE FATIGABILITY IN PEOPLE WITH PRE-D. AIM 1.1 WILL COMPARE LEG BLOOD FLOW AND SKELETAL MUSCLE OXYGENATION IN RESPONSE TO DYNAMIC FATIGUING EXERCISE BETWEEN PEOPLE WITH PRE-D, HEALTHY CONTROLS AND T2D. GROUPS WILL BE MATCHED FOR AGE, SEX, BODY MASS INDEX AND PHYSICAL ACTIVITY LEVELS TO DETERMINE DISEASE- RELATED VASCULAR FUNCTION AND FATIGABILITY RATHER THAN INACTIVITY-RELATED CHANGES ACROSS THE DIABETIC SPECTRUM. SKELETAL MUSCLE BLOOD FLOW THROUGH THE FEMORAL ARTERY WILL BE QUANTIFIED WITH ULTRASONOGRAPHY AND SKELETAL MUSCLE OXYGENATION WITH NIRS DURING A DYNAMIC FATIGUING KNEE EXTENSION EXERCISE. AIM 1.2 WILL DETERMINE ENDOTHELIAL VASCULAR FUNCTION AT MACRO- AND MICRO-VASCULAR LEVELS IN PEOPLE WITH PRE-D AND T2D. FLOW-MEDIATED DILATION WILL BE ASSESSED IN VIVO IN THE FEMORAL ARTERY USING ULTRASONOGRAPHY AND IN ISOLATED ARTERIOLES EXTRACTED FROM THE VASTUS LATERALIS MUSCLE BIOPSIES. AIM 2 IS A CLINICAL TRIAL THAT WILL DETERMINE THE EFFECTIVENESS OF RESISTANCE EXERCISE TRAINING COUPLED WITH BLOOD FLOW RESTRICTION TO IMPROVE FATIGABILITY AND VASCULAR FUNCTION IN PEOPLE WITH DIABETES. PEOPLE WITH PRE-D AND T2D WILL PERFORM 8 WEEKS OF UNILATERAL RESISTANCE TRAINING IN WHICH ONE LEG IS EXERCISED WITH FREELY PERFUSED CONDITIONS AND THE OTHER LEG WITH BLOOD FLOW RESTRICTION. THUS, BLOOD FLOW RESTRICTION AND RESISTANCE TRAINING WILL BE USED AS A PROBE TO FURTHER UNDERSTAND THE MECHANISMS OF FATIGABILITY ALONG THE VASCULAR TREE IN PEOPLE WITH PRE-D AND T2D, AND TEST TRAINING STRATEGIES TO IMPROVE FATIGABILITY IN THIS POPULATION.

SEXUAL DIMORPHIC CIRCUITS IN PHOTOPERIODIC ENCODING AND PHOTIC PROCESSING - PROJECT SUMMARY/ABSTRACT LIGHT REGULATES NEUROLOGICAL FUNCTION THROUGH CIRCUITS THAT REMAIN POORLY DEFINED, AND THERE REMAINS A SIGNIFICANT UNMET NEED IN UNDERSTANDING PHOTIC PLASTICITY IN THE BRAIN OF BOTH SEXES. FOR EXAMPLE, SEASONAL CHANGES IN DAY LENGTH (I.E., PHOTOPERIOD) MODULATE SLEEP, ATTENTION, APPETITE, METABOLISM, MOOD, AND IMMUNE FUNCTION OCCUR IN A LARGE NUMBER OF PEOPLE, WITH UP TO 80% BEING WOMEN. THE SUPRACHIASMATIC NUCLEUS (SCN) DRIVES CIRCADIAN AND PHOTOPERIODIC RESPONSES TO LIGHT, BUT THERE IS A LARGE GAP IN OUR UNDERSTANDING OF SEX DIFFERENCES IN SCN PHOTIC AND PHOTOPERIODIC PROCESSING. OUR PRELIMINARY DATA INDICATE THAT CIRCADIAN AND PHOTOPERIODIC RESPONSES DIFFER BY SEX, WITH FEMALES DISPLAY LARGER BEHAVIORAL RESPONSES TO LIGHT MEDIATED BY DIVERGENT SCN CIRCUITS. BASED ON THESE DATA, WE PROPOSE THE CENTRAL HYPOTHESIS THAT PHOTIC PROCESSING DIFFERS BETWEEN MALES AND FEMALES BECAUSE THE RETINA-SCN CIRCUIT IS SEXUAL DIMORPHIC. WE WILL TEST THAT BIOLOGICAL SEX INFLUENCES CELLULAR RESPONSES TO LIGHT (AIM1), PHOTOPERIODIC RESPONSES TO DAY LENGTH (AIM2), AND NEURAL ADAPTATIONS IN SCN CIRCUITS (AIM3). THESE STUDIES WILL BENEFIT FROM THE COLLECTIVE EXPERTISE OF THIS COLLABORATIVE RESEARCH TEAM, WHICH SPECIALIZES IN RETINAL PHYSIOLOGY, SCN NETWORK PROPERTIES, CELLULAR IMAGING, AND COMPUTATIONAL ANALYSES. INDEPENDENT OF SEX DIFFERENCES, SUCCESSFUL COMPLETION OF THESE STUDIES WILL PROVIDE NOVEL INSIGHTS INTO NEURAL MECHANISMS OF PHOTIC PROCESSING AND PHOTOPERIODIC ENCODING TO ADVANCE UNDERSTANDING IN BOTH SEXES. FURTHER, THIS WORK IS EXPECTED TO PROVIDE INFORMATION THAT WILL BE CRITICAL TO BETTER UNDERSTANDING DISEASES INCURRED BY OTHER FORMS OF LIGHT-INDUCED DISRUPTION (E.G., SHIFTWORK, JETLAG).

CYBERCORPS SCHOLARSHIP FOR SERVICE: EXPANDING THE CYBERSECURITY WORKFORCE AND CURRICULUM ASSESSMENT METHODS IN THE STATE OF WISCONSIN (CYBERWIN) -THE CYBERWIN PROJECT AT MARQUETTE UNIVERSITY (MU), A NATIONAL CENTER OF ACADEMIC EXCELLENCE IN CYBER DEFENSE EDUCATION (CAE-CDE), WILL RECRUIT AND TRAIN THE NEXT GENERATION OF CYBERSECURITY PROFESSIONALS TO MEET THE NEEDS OF THE PUBLIC SECTOR. CYBERWIN WILL SUPPORT A TOTAL OF 16 STUDENTS ACROSS THE ACCELERATED AND TRADITIONAL COMPUTER AND INFORMATION SCIENCE M.S. PROGRAMS, WITH A SPECIALIZATION IN INFORMATION ASSURANCE AND CYBER DEFENSE, AND THE COMPUTER SCIENCE PHD PROGRAM, WITH CYBERSECURITY-FOCUSED RESEARCH. APART FROM THEIR INVOLVEMENT IN RIGOROUS COURSEWORK, RESEARCH PROJECTS IN CYBERSECURITY AND LEARNING ANALYTICS, SYMPOSIA, AND HACKATHONS, THE 16 SCHOLARS WILL ALSO MENTOR MILWAUKEE HIGH SCHOOL STUDENTS OF THE FEDERAL TRIO PROGRAM, UPWARD BOUND MATH & SCIENCE, WITH THE GOAL OF BROADENING PARTICIPATION IN COMPUTING AND CYBERSECURITY. CYBERWIN HAS FIVE GOALS: (1) PRODUCE 14 MASTER?S DEGREE GRADUATES AND 2 PHD DEGREE GRADUATES IN CYBERSECURITY DURING THE FIVE-YEAR PERIOD OF THE PROJECT, (2) RECRUIT PROSPECTIVE SCHOLARS WITH HIGH POTENTIAL OF ACADEMIC SUCCESS FROM DIVERSE BACKGROUNDS, (3) PROVIDE HIGH QUALITY INSTRUCTION, ESPECIALLY IN CORE CYBERSECURITY CLASSES, (4) CULTIVATE A STRONG, COLLABORATIVE RELATIONSHIP WITH STATE AND FEDERAL AGENCIES TO PLACE SCHOLARS IN INTERNSHIPS AND FULL TIME APPOINTMENTS, AND (5) CONTRIBUTE A NOVEL PROGRAM ASSESSMENT METHODOLOGY, BASED ON CONCEPT MAPS, TO THE LEARNING ANALYTICS COMMUNITY. THROUGH THIS NOVEL ASSESSMENT, THE PROJECT WILL FURTHER EVALUATE AND COMPARE THE PROFESSIONAL DEVELOPMENT OF SPECIFIC GROUPS BASED ON, FOR EXAMPLE, COURSEWORK, INTERNSHIP EXPERIENCES, OR DEMOGRAPHICS. CYBERWIN HAS THE POTENTIAL TO UNCOVER THE HIGH-IMPACT PRACTICES THAT INCREASE STUDENTS? COMMITMENT AND ANY EFFECTS THAT PERSONAL EXPERIENCES MAY HAVE ON DETERMINING THEM. THIS FRAMEWORK AIMS TO CAPTURE THE WHOLE EDUCATIONAL EXPERIENCE THROUGH RICH, MULTI-DIMENSIONAL ANALYSIS THAT CAN BE ADOPTED BY OTHER INSTITUTIONS. THIS PROJECT IS SUPPORTED BY THE CYBERCORPS? SCHOLARSHIP FOR SERVICE (SFS) PROGRAM, WHICH FUNDS PROPOSALS ESTABLISHING OR CONTINUING SCHOLARSHIP PROGRAMS IN CYBERSECURITY AND ALIGNS WITH THE U.S. NATIONAL CYBER STRATEGY TO DEVELOP A SUPERIOR CYBERSECURITY WORKFORCE. FOLLOWING GRADUATION, SCHOLARSHIP RECIPIENTS ARE REQUIRED TO WORK IN CYBERSECURITY FOR A FEDERAL, STATE, LOCAL, OR TRIBAL GOVERNMENT ORGANIZATION FOR THE SAME DURATION AS THEIR SCHOLARSHIP SUPPORT.? THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

GLOBAL ANALYSIS OF THE SUPRASPINAL CONNECTOME AFTER SPINAL CORD INJURY - PROJECT SUMMARY THE SUPRASPINAL CONNECTOME REFERS TO THE FULL SET OF NEURONS THAT RESIDE IN THE BRAIN AND PROJECT AXONS TO THE SPINAL CORD. THE SHEER COMPLEXITY OF THIS CONNECTOME, BOTH ANATOMICAL AND FUNCTIONAL, HAS PRESENTED STUBBORN CHALLENGES TO UNDERSTANDING AND TREATING THE HIGHLY VARIABLE DISRUPTION THAT ACCOMPANIES SPINAL INJURY. ANATOMICALLY, THE WIDE DISTRIBUTION OF THE CELL BODIES HAS MADE IT VERY DIFFICULT TO TRACE AND QUANTIFY ALL POPULATIONS SIMULTANEOUSLY, LEADING MOST STUDIES TO FOCUS ON JUST ONE OR SEVERAL MAIN SUPRASPINAL CELL TYPES. FUNCTIONALLY, DESCENDING CONTROL IS DISTRIBUTED ACROSS MULTIPLE POPULATIONS WITH OUTPUTS THAT CAN BE COMPLEMENTARY, ANTAGONISTIC, OR POTENTIALLY COMPENSATORY AFTER INJURY. THESE FUNCTIONAL RELATIONSHIPS STRONGLY AFFECT OUTCOMES AFTER SPINAL INJURY BUT ARE DIFFICULT TO CAPTURE IN SINGLE- OR SEVERAL-TRACT APPROACHES. THIS PROJECT AIMS TO ADVANCE THE FIELD THOUGH AN APPROACH THAT YIELDS A COMPREHENSIVE UNDERSTANDING OF SPINAL INJURY AT A WHOLE-CONNECTOME LEVEL AND BY PROVIDING NEW VIRAL TOOLS TO SELECTIVELY MANIPULATE SUBTYPES OF BRAIN-SPINAL NEURONS. FIRST, WE WILL USE 3D WHOLE-BRAIN AND -SPINAL IMAGING TO VISUALIZE AND PRECISELY QUANTIFY THE NUMBER AND ACTIVITY LEVEL OF SPARED NEURONS IN ALL SUPRASPINAL CELL TYPES ACROSS COHORTS OF ANIMALS THAT RECEIVE GRADED CONTUSION INJURIES, WHILE SIMULTANEOUSLY MEASURING BOTH SPONTANEOUS AND REHABILITATION-INDUCED RECOVERY OF FUNCTION. WITH WHOLE-BRAIN DATA AND ADVANCED STATISTICAL TECHNIQUES WE CAN TAKE ADVANTAGE OF THE NATURAL VARIABILITY BETWEEN INDIVIDUAL ANIMALS TO IDENTIFY THE ELEMENTS OF THE CONNECTOME THAT ARE MOST PREDICTIVE OF RECOVERY. NEXT, WE WILL SYSTEMATICALLY TEST THESE PREDICTED FUNCTIONAL RELATIONSHIPS BY TARGETED, REVERSIBLE CHEMOGENETIC SILENCING OF SELECTED SUPRASPINAL POPULATIONS BEFORE INJURY, AFTER INJURY, AND AFTER REHABILITATION. IMPORTANTLY, THESE SILENCING EXPERIMENTS WILL EMPLOY BOTH DIRECT TARGETING OF BRAIN REGIONS AND NEWLY DEVELOPED VIRAL TOOLS THAT ENABLE SELECTIVE MANIPULATION OF DEFINED SUBTYPES OF SPINALLY PROJECTING NEURONS. COLLECTIVELY, THESE CONNECTOME-LEVEL DATA AND NEW SUBTYPE-SPECIFIC TOOLS ARE NEEDED TO 1) HELP RESOLVE LURKING VARIABILITY THAT CURRENTLY CHALLENGES THE FIELD, 2) PROVIDE A COMPREHENSIVE, RATIONAL FRAMEWORK THAT PRIORITIZES INTEREST IN THE FULL SETS OF SUPRASPINAL POPULATIONS OF HIGHEST RELEVANCE TO FUNCTIONAL RECOVERY, AND 3) PROVIDE A PIPELINE AND DATA RESOURCES THAT EXTRACTS MAXIMAL, BRAIN-WIDE INFORMATION FROM PRE-CLINICAL MODELS OF SPINAL INJURY TO MORE FULLY ALIGN THEM WITH THE COMPLEX NEEDS OF INDIVIDUALS LIVING WITH SCI.

MARQUETTE UNIVERSITY COLLEGE OF NURSING – MUCON HEROES PROJECT (HEALTH EDUCATION AND RETENTION OPTIMIZATION THROUGH EQUIPMENT AND SIMULATION)

DEEP LEARNING ENABLED, DEEP ULTRAVIOLET SCANNING MICROSCOPY FOR INTRAOPERATIVE ASSESSMENT OF MARGIN STATUS DURING BREAST CANCER SURGERY - WOMEN WITH POSITIVE MARGINS AFTER BREAST-CONSERVING SURGERY (BCS) HAVE A 2-FOLD INCREASED RISK OF CANCER RECURRENCE AND ARE RECOMMENDED TO UNDERGO ADDITIONAL RE-EXCISION SURGERY TO ACHIEVE NEGATIVE MARGINS. ADDITIONAL SURGERY IS ASSOCIATED WITH SIGNIFICANT EMOTIONAL, COSMETIC AND FINANCIAL BURDENS FOR PATIENTS AND THEIR CAREGIVERS. ALTHOUGH RADIOGRAPHY, FROZEN SECTION, TOUCH PREP AND MARGINPROBE ARE AVAILABLE FOR INTRAOPERATIVE MARGIN ASSESSMENT, THEIR ACCURACY IS VARIABLE AND MOST, EXCEPT RADIOGRAPHIC EXAMINATION, ARE TIME- AND LABOR- INTENSIVE AND NOT ROUTINELY USED. SINCE PUBLICATION OF THE 2014 SSO-ASTRO GUIDELINES FOR INVASIVE CANCER RECOMMENDING RE-EXCISION FOR POSITIVE MARGINS ONLY, THE RE-EXCISION RATES HAVE DECREASED BUT REMAIN SUBSTANTIAL (14-18%) WITH SIGNIFICANT VARIATION AMONG SURGEONS. BECAUSE THE SIZE OF BCS SPECIMENS VARIES SIGNIFICANTLY (A FEW TO >40 CM2 PER MARGIN) AND POSITIVE MARGINS OFTEN INCLUDE ONE OR MULTIPLE SITES/FOCI, A DEVICE WITH BOTH VARIABLE MARGIN COVERAGE AND MICROSCOPIC RESOLUTION THAT CAN ACCURATELY EVALUATE AN ENTIRE SURGICAL SPECIMEN WITHIN A FEW MINUTES IS HIGHLY DESIRABLE. WHILE NEW TECHNOLOGIES HAVE BEEN PROPOSED, THEY ARE EITHER POINT OR HIGH RESOLUTION DEVICES WITH A VERY SMALL FIELD-OF-VIEW THAT REQUIRES EXCESSIVE TIME TO SCAN A SPECIMEN, OR WIDE- FIELD DEVICES WITH LOW RESOLUTION AND POOR SENSITIVITY. NONE HAS DEMONSTRATED THE CAPABILITY OF ANALYZING AN ENTIRE LUMPECTOMY SPECIMEN WITH BOTH ADEQUATE RESOLUTION AND TIME EFFICIENCY IN A CLINICAL SETTING. OUR GOAL IS TO DEVELOP A DEEP LEARNING (DL) ENABLED, DEEP ULTRAVIOLET (DUV) SCANNING MICROSCOPE (DDSM) FOR SUBCELLULAR RESOLUTION AND RAPID (<5 MIN) EXAMINATION OF FRESHLY EXCISED TUMOR SPECIMENS DURING BCS. WE HYPOTHESIZE THAT THERE ARE SIGNIFICANT SUBCELLULAR OPTICAL CONTRASTS THAT CAN BE IDENTIFIED BY THE DDSM TO DIFFERENTIATE BREAST CANCER CELLS FROM NORMAL TISSUE. OUR PRELIMINARY DUV IMAGES DEMONSTRATE EXCELLENT CONTRASTS AND ACCURACY FOR IDENTIFICATION OF BREAST CANCER CELLS. WE PROPOSE THAT LARGE AND VARIABLE MARGIN COVERAGE, MICROSCOPIC RESOLUTION AND HIGH SPEED ARE ACHIEVED BY USING: 1) DUV LIGHT FOR SURFACE EXCITATION OF FRESH SPECIMENS; 2) PARALLEL IMAGING OF TWO MARGINS; 3) A LOW OPTICAL MANIFICATION FOR FAST SPEED; AND 4) DL AND SPARSE-SAMPLING (SS) TO RAPIDLY SEARCH FOR PATHOLOGICAL FEATURES OF CANCER CELLS. IN AIM 1, A NOVEL DDSM INSTRUMENT WILL BE DEVELOPED AND USED TO IMAGE 120 FRESH BREAST TISSUES. DL CLASSIFICATION ALGORITHMS WILL BE DEVELOPED AND VALIDATED USING THE 120 TISSUE SAMPLES IN AIM 2. AIM 3 WILL INTEGRATE DL AND SS ALGORITHMS INTO THE DDSM AND DEMONSTRATE FOR FAST DETECTION OF VARIABLE AMOUNT OF CANCER CELLS ON THE SURFACES OF BREAST TUMOR SPECIMENS. DDSM IS HIGHLY INNOVATIVE, COMBINING DUV MICROSCOPY, PARALLEL IMAGING, DL CLASSIFICATION, AND SS IN A FAST, COMPACT, AUTOMATED DESIGN. DURING INITIAL BCS, IF THE DDSM ACCURATELY AND EFFICIENTLY IDENTIFIES POSITIVE MARGINS, ADDITIONAL BREAST TISSUE WOULD BE REMOVED FROM THE SURGICAL CAVITY UNTIL NEGATIVE MARGINS ARE ACHIEVED AND UNNECESSARY REMOVAL OF ADDITIONAL TISSUE WOULD BE AVOIDED, THUS DECREASE THE NEED FOR ADDITIONAL SURGERY. DDSM IS A PLATFORM TECHNOLOGY THAT CAN BE USED WITH OTHER IMAGING MODALITIES OR ADAPTED FOR DETECTION OF OTHER CANCER OR NONCANCER CONDITIONS.

MKE ROOTS: IMPROVING K12 CIVIC EDUCATION IN MILWAUKEE COUNTY

MARQUETTE UNIVERSITY UPWARD BOUND MATH AND SCIENCE PROGRAM

MARQUETTE EDUCATIONAL TALENT SEARCH PROGRAM

OPIOID-INDUCED DYSREGULATION OF CORTICO-STRIATAL CIRCUITS - PROJECT SUMMARY/ABSTRACT OPIOID-BASED DRUGS ARE MAINSTAYS FOR PAIN MANAGEMENT DESPITE THE RISK OF DEPENDENCE, ADDICTION, AND COGNITIVE IMPAIRMENTS, EVEN WHEN TAKEN AS DIRECTED. YET, THE NEUROLOGICAL UNDERPINNINGS OF OPIOID ADDICTION REMAIN RELATIVELY UNDER-INVESTIGATED, THEREBY LIMITING OUR UNDERSTANDING OF THE NEURAL AND ASSOCIATED PSYCHOLOGICAL BASIS OF ADDICTION TO OPIOIDS. IMPAIRED DECISION-MAKING, STRONG PERSEVERANCE AND AN EXTRAORDINARY MOTIVATION TO OBTAIN DRUG ARE WIDELY SEEN AS CORE ASPECTS OF ADDICTION. THESE BEHAVIORS ARE EXPRESSED ONLY BY A FRACTION OF THOSE EXPOSED TO THE DRUG – HIGHLIGHTING A SIGNIFICANT DEGREE OF INDIVIDUAL VARIABILITY AND A NEED TO IDENTIFY LARGELY UNKNOWN FACTORS THAT CONVEY RISK OR RESILIENCE. HYPOFUNCTION OF PREFRONTAL CIRCUITS HAS EMERGED AS A PRIMARY MECHANISM BY WHICH THIS TRANSITION OCCURS, HOWEVER EVIDENCE REGARDING THE NATURE, SUB-CIRCUIT(S) LOCUS, AND DEVELOPMENT OF THIS HYPOFUNCTION IS LACKING. OUR PUBLISHED DATA FIND THAT SELF-ADMINISTRATION (SA) OF THE POTENT OPIOID, REMIFENTANIL (REM), PROMOTES A PROGRESSIVE HYPOACTIVE STATE IN PRELIMBIC CORTEX (PRL) PYRAMIDAL NEURONS THAT UNDERLIES IMPAIRMENTS IN COGNITIVE FLEXIBILITY, AND THAT THIS PHENOMENON OCCURS ON A FASTER TIMELINE IN FEMALES. PILOT DATA INDICATE INFLEXIBILITY ALIGNS WITH INCREASED PERSEVERATIVE DRUG SEEKING AND MOTIVATION FOR DRUG THAT IS MORE PROMINENT IN FEMALES. WE PREDICT THESE CHANGES EMERGE AS A RESULT OF CHANGES IN PL-CORE CIRCUITS, AS PILOT DATA INDICATE THAT HYPOACTIVITY IS MORE PROMINENT IN PRL-CORE PN AND THAT THIS PLASTICITY ALIGNS WITH SEX- AND CELL-TYPE SPECIFIC ADAPTATIONS IN SYNAPTIC STRENGTH AT DOWNSTREAM CORE MEDIUM SPINY NEURONS (MSNS) BASED ON EXPRESSION OF DOPAMINE TYPE I (D1) VERSUS TYPE II (D2) RECEPTORS. THIS PROPOSAL WILL COMBINE CIRCUIT-SPECIFIC EX VIVO MEASURES OF PLASTICITY, IN VIVO CA2+ IMAGING, AND CHEMOGENETICS WITH A NOVEL SA MODEL THAT PERMITS LONGITUDINAL ASSESSMENT OF INDIVIDUAL VARIABILITY IN THE DEVELOPMENT OF MOTIVATED AND PERSEVERATIVE DRUG-SEEKING AND A CLINICALLY RELEVANT OPERANT MODEL TO ASSESS COGNITIVE FLEXIBILITY (STRATEGY SHIFTING) TO IDENTIFY CHANGES FROM SYNAPSE TO FUNCTION TO BEHAVIOR. AIM1 OF THIS PROPOSAL WILL FURTHER INVESTIGATE EXPOSURE DEPENDENT CHANGES WITHIN PRL-CORE CIRCUITS USING PATHWAY-SPECIFIC EX VIVO ELECTROPHYSIOLOGY. INTERSECTIONAL CHEMOGENETIC MANIPULATIONS WILL ASSESS THE CONTRIBUTION OF THIS CIRCUIT FLEXIBILITY AND DRUG SEEKING AND WHETHER DYSFUNCTION UNDERLIES DEFICITS IN FLEXIBILITY AND CHANGES IN PERSEVERANCE/MOTIVATION. AIM2 WILL USE CA2+ IMAGING TO EXAMINE THE CORRESPONDING DISRUPTIVE EFFECTS OF OPIOID PLASTICITY ON PRL-CORE INFORMATION PROCESSING ASSOCIATED WITH DECISION MAKING AND MEASURE LONGITUDINAL CHANGES IN BASAL STATES AND ACTIVITY ENCODING OPIOID TAKING WITH PROGRESSIVE SA. AIM 3 WILL IDENTIFY SYNAPTIC MODIFICATIONS AT PRL-CORE D1- AND D2- MSN SYNAPSES. CONTRALATERAL CHEMOGENETIC TARGETING WILL DETERMINE CONTRIBUTIONS OF PRL-TO-D1-MSN AND PRL- TO-D2-MSN CIRCUITS IN FLEXIBILITY AND LONGITUDINALLY DETERMINE IF CONTRIBUTIONS TO OPIOID TAKING AND BEHAVIOR SHIFTS OVER TIME. PROPOSED STUDIES WILL PROVIDE NOVEL INSIGHT INTO PROGRESSIVELY DEVELOPING CHANGES IN FUNCTION AND BEHAVIOR, WITH THE POTENTIAL TO INFORM MORE TAILORED TREATMENTS BASED ON SEX AND STAGE OF ADDICTION.

ESTABLISHING THE OPEN DENTAL EDUCATION CONSORTIUM

ADVANCING FUNCTIONAL ASSESSMENT OF PEDIATRIC FLATFOOT USING WEIGHTBEARING CT - PROJECT SUMMARY THE FOOT IS A COMPLEX STRUCTURE AND SEVERE DEFORMITIES SUCH AS FLATFEET ARE COMMON AMONG CHILDREN, PARTICULARLY THOSE WITH NEUROLOGIC DISORDERS. TREATMENT OF PEDIATRIC FOOT DEFORMITIES IS CURRENTLY LIMITED BY THE INADEQUATE VISUALIZATION PROVIDED BY STANDARD OF CARE 2D RADIOGRAPHS. THESE RADIOGRAPHIC IMAGES ARE LIMITED TO A SINGLE POINT OF VIEW AND FLATTEN IRREGULARLY SHAPED, 3D FOOT BONES INTO 2D OBJECTS. WEIGHTBEARING COMPUTED TOMOGRAPHY (WBCT) IS AN EMERGING TECHNOLOGY THAT ALLOWS FOR FULL VOLUMETRIC ASSESSMENT OF THE FOOT IN WEIGHTBEARING WITH EQUIVALENT OR LESS RADIATION EXPOSURE THAN A CURRENT STANDARD OF CARE FOOT & ANKLE RADIOGRAPH SERIES. INTERNATIONAL EXPERTS HAVE CALLED WBCT A “GAME-CHANGER” DUE TO ITS ABILITY TO OBSERVE PATHOLOGIES IN THE ADULT FOOT PREVIOUSLY NOT ABLE TO BE SEEN INCLUDING SUBTALAR JOINT ALIGNMENT, IMPINGEMENT, AND SUBLUXATION WHICH HAVE IMPORTANT CLINICAL IMPLICATIONS. WBCT HAS ADVANCED KNOWLEDGE OF FOOT AND ANKLE MORPHOLOGY WITH A CONSENSUS FOR ITS USE IN ADULT SYMPTOMATIC PES PLANUS/FLATFEET. DESPITE THE SUCCESSES AND CHANGES IN CLINICAL PARADIGMS RESULTING FROM THE TECHNOLOGICAL ADVANCES OF WBCT, ITS APPLICATIONS HAVE BEEN LIMITED TO ADULT FOOT DEFORMITY AND HAVE NOT BEEN TRANSLATED TO PEDIATRIC POPULATIONS, CREATING A LARGE KNOWLEDGE GAP IN OUR UNDERSTANDING OF FOOT PATHOLOGIES THROUGHOUT GROWTH AND DEVELOPMENT. PLANUS DEFORMITY, WITH REPORTED INCIDENCE AS HIGH AS 44% OF CHILDREN, IS OF PARTICULAR INTEREST DUE TO LACK OF UNDERSTANDING IN STRUCTURAL CHANGES THAT MAY CAUSE PAIN AND DYSFUNCTION LATER IN YOUNG ADULTHOOD. OUR OVERALL OBJECTIVE FOR THE CURRENT MULTISITE PROJECT IS TO COMPLETE A COMPREHENSIVE STUDY OF THE 3D STRUCTURE AND FUNCTION OF PEDIATRIC PLANUS FEET. TO ACCOMPLISH THIS GOAL, WE PROPOSE TWO SPECIFIC AIMS. SPECIFIC AIM 1 TO COMPLETE A CROSS SECTIONAL EVALUATION OF CHILDREN WITH PLANUS FOOT DEFORMITY USING CURRENT STANDARD-OF-CARE 2D RADIOGRAPHIC ANALYSIS AND EQUIVALENT METRICS OBTAINED FROM 3D WBCT. WE WILL ALSO EXPLORE RELATIONSHIPS BETWEEN JOINT FORM AND FUNCTION. SPECIFIC AIM 2 IS TO COMPLETE A LONGITUDINAL EVALUATION OF CHILDREN WITH PLANUS FOOT DEFORMITY TO DETERMINE RADIOGRAPHIC AND FUNCTIONAL METRICS THAT ARE PREDICTIVE OF WORSENING SYMPTOMS AND ARCH COLLAPSE. THE LONG-TERM FOCUS OF THIS PROJECT IS TO PROVIDE A MORE COMPREHENSIVE ASSESSMENT OF THE 3D STRUCTURE AND FUNCTION OF PLANUS FOOT STRUCTURE IN CHILDREN. THIS WILL ALLOW FOR ACCURATE CLINICAL ASSESSMENT AND TARGETED TREATMENT PLANNING THROUGH IMPROVED RADIOGRAPHIC MEASUREMENTS AND THE ABILITY TO DIAGNOSE THESE COMPLEX FOOT DISORDERS IN DEVELOPING CHILDREN.

TO COVER TUITION AND FEES FOR THE INSTATE AND OUT OF STATE STUDENTS ON A NAVAL ROTC SCHOLARSHIP FOR THE WINTER 2009, WINTER AND SPRING QUARTERS, AND SPRING 2010 SEMESTER.

TO COVER TUITION AND FEES FOR THE INSTATE AND OUT OF STATE STUDENTS ON A NAVAL ROTC SCHOLARSHIP FOR THE SPRING OF 2011 SEMESTER.

SPECT IMAGING AND COMPUTATIONAL MODELING FOR ASSESSMENT OF ACUTE LUNG INJURY

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM - PROJECT TITLE: MARQUETTE BEHAVIORAL WORKFORCE EDUCATION AND SUPERVISOR SUPPORT APPLICANT NAME: MARQUETTE UNIVERSITY, COLLEGE OF EDUCATION ADDRESS: P.O. BOX 1881, SCHROEDER COMPLEX, MILWAUKEE, WI 53201-1881 PROJECT DIRECTOR: LEE ZA ONG, PHD, LPC, CRC., 414-288-1550, LEEZA.ONG@MARQUETTE.EDU WEBSITE ADDRESS: HTTPS://WWW.MARQUETTE.EDU/EDUCATION/GRADUATE/CECP/INDEX.PHP PROGRAM DISCIPLINE: PROFESSIONAL COUNSELING AMOUNT REQUESTED: $ 2,400,000 FOR 4 YEARS (7/1/2025 – 6/30/2029) FUNDING PREFERENCE REQUESTED: QUALIFICATION 1: HIGH RATE THIS PROJECT AIMS TO EXPAND EXPERIENTIAL TRAINING OPPORTUNITIES TO IMPROVE THE DISTRIBUTION AND SUPPLY OF THE BEHAVIORAL HEALTH WORKFORCE, PARTICULARLY CLINICAL MENTAL HEALTH COUNSELORS WITH A CHILD AND ADOLESCENT SPECIALIZATION. THE PROJECT WILL ALSO RECRUIT, DEVELOP, AND EXPAND THE CAPACITY TO TRAIN CLINICAL SUPERVISORS TO SUPPORT THE TRAINEES. THE PROPOSAL SEEKS FUNDING TO PROVIDE STIPENDS TO MASTER’S STUDENTS IN NEED DURING THEIR FINAL YEAR OF EXPERIENTIAL TRAINING. THE REQUESTED FUNDS WILL PROVIDE CRITICAL SUPPORT FOR THESE STUDENTS, ESPECIALLY THOSE FROM UNDERREPRESENTED BACKGROUNDS, TO OBTAIN A GRADUATE DEGREE EDUCATION; WILL EXPAND THE DIVERSITY OF THE WORKFORCE; AND WILL INCREASE ACCESS TO QUALITY BEHAVIORAL HEALTH SERVICES, ESPECIALLY IN UNDERSERVED AND RURAL COMMUNITIES. THIS PROJECT IS A COMPETING CONTINUATION PROJECT BUILT UPON THE DEPARTMENT OF COUNSELOR EDUCATION AND COUNSELING PSYCHOLOGY’S (CECP) CLINICAL MENTAL HEALTH COUNSELING – CHILD AND ADOLESCENT SPECIALIZATION PROGRAM (CMHC-CAS), THE ONLY CHILD AND ADOLESCENT COUNSELING PROGRAM (ONLINE AND ON-CAMPUS) IN WISCONSIN. THIS CACREP-ACCREDITED PROGRAM HAS PROVIDED EVIDENCE-BASED AND EMERGING BEST PRACTICES IN CLINICAL MENTAL HEALTH SERVICES FOR CHILDREN, ADOLESCENTS, AND THEIR FAMILIES SINCE 2013. THE PROPOSED FOUR-YEAR PROJECT ADDRESSES THE BHWET PROGRAM OBJECTIVES BY: (A) INCREASING THE NUMBER OF NEW OR EXPANDED COMMUNITY PARTNERSHIPS WITH EXPERIENTIAL TRAINING SITES IN HIGH-NEED AND HIGH-DEMAND AREAS; (B) PROMOTING COLLABORATIVE TRAINING BY USING TEAM-BASED MODELS OF CARE TO INTEGRATE BEHAVIORAL HEALTH CARE INTO INTERPROFESSIONAL PRIMARY CARE SETTINGS; (C) RECRUITING A DIVERSE WORKFORCE INTERESTED IN WORKING WITH CHILDREN, ADOLESCENTS, AND YOUNG ADULTS; AND (D) RECRUITING, DEVELOPING, AND EXPANDING THE CAPACITY TO TRAIN CLINICAL SUPERVISORS TO SUPPORT AND MENTOR BEHAVIORAL HEALTH TRAINEES. THE PROJECT WILL IMPLEMENT SUCCESS STRATEGIES FOR STUDENTS WHO ARE FROM UNDERREPRESENTED BACKGROUNDS BY PROVIDING STUDENT-CENTERED ADVISING AND SUPERVISION. GROUNDED IN THE JESUIT PRINCIPLE OF CURA PERSONALIS (CARE FOR THE WHOLE PERSON), THE CMHC-CAS CURRICULUM EMPHASIZES EVIDENCE-BASED, INTERPROFESSIONAL, TRAUMA-INFORMED CARE WITH A FOCUS ON CULTURAL HUMILITY AND SOCIAL JUSTICE. IT SHAPES GRADUATES INTO PROVIDERS WHO RESPECT AND RESPOND TO INDIVIDUALS’ HOLISTIC GROWTH, WELLNESS, AND HEALTH NEEDS. CLINICAL PLACEMENTS ARE AVAILABLE AT PRIMARY CARE SETTINGS IN HIGH-NEED AND HIGH-DEMAND AREAS THROUGHOUT MILWAUKEE COUNTY AND NORTHEAST WISCONSIN. WE BUILD STRONG COMMUNITY PARTNERSHIPS THROUGH FREE, QUALITY PROFESSIONAL DEVELOPMENT AND SUPERVISION TRAINING. GRADUATES RECEIVE EMPLOYMENT SUPPORT VIA NETWORKING, EMPLOYER RELATIONS, AND ALUMNI COLLABORATION. WITH THIS PROPOSED PROJECT, WE WILL INCREASE THE NUMBER OF BEHAVIORAL HEALTH PROVIDERS WHO SPECIALIZE IN CHILD AND ADOLESCENT COUNSELING, AND WHO REFLECT THE DEMOGRAPHICS OF THE RECIPIENTS OF BEHAVIORAL HEALTH SERVICES IN THE COMMUNITY. THE PROJECT WILL OFFER $25,000 INTERNSHIP STIPENDS TO EACH ELIGIBLE STUDENT PER YEAR – AT LEAST 68 STUDENTS BY THE YEAR 2029 – FOR A GRANT TOTAL OF $ 2,400,000.

MU POSTAWARD OPTIMIZATION FOR STRATEGIC TRANSFORMATION (MU POST) -TO PROVIDE FACULTY MORE TIME TO DEVOTE TO RESEARCH ACTIVITIES, THE MARQUETTE UNIVERSITY POST-AWARD OPTIMIZATION FOR STRATEGIC TRANSFORMATION (MU-POST) PROJECT FOCUSES ON PROCESS IMPROVEMENTS THAT REDUCE THE ADMINISTRATIVE BURDEN ASSOCIATED WITH SPONSORED AWARD MANAGEMENT. SMALL AND MID-SIZED UNIVERSITIES OFTEN LACK ROBUST RESEARCH SUPPORT AND SERVICE INFRASTRUCTURE. WITH DEFINED RESOURCES AND EFFECTIVE PROCESSES SUPPORTING THEM, FACULTY CAN DEDICATE MORE TIME TO THEIR RESEARCH, COMPLETE MILESTONES ON SCHEDULE, COLLABORATE WITH COLLEAGUES, MENTOR STUDENTS, AND INCREASE THEIR PUBLICATION RATE. REDUCING ADMINISTRATIVE BURDEN THROUGH PROCESS IMPROVEMENTS LESSENS THE ORGANIZATIONAL COMPLEXITIES THAT COME WITH HAVING A GRANT AND ULTIMATELY FOSTERS GROWTH IN THE NATION?S RESEARCH CAPACITY. MU-POST DEVELOPS STRATEGIES, PROCESSES, AND MODELS THAT CAN BE UTILIZED BY SMALL TO MID-SIZE INSTITUTIONS TO GROW CAPACITY, ACCESS, AND VISIBILITY WITHIN THE POST-AWARD SECTOR. THE PROJECT HAS TWO MAJOR OBJECTIVES: 1) TO TEST THE IMPLEMENTATION OF POST-AWARD ADVOCATES, ROLES THAT BRIDGE THE GAP BETWEEN A CENTRAL SPONSORED PROGRAMS OFFICE, FACULTY MEMBERS, AND THEIR DEPARTMENTS AND OTHER UNITS, AND 2) TO DEVELOP AND IMPLEMENT BROAD CHANGES IN POST-AWARD PROCESSES AND SYSTEMS TO ALLOW FOR SCALABILITY, EFFICIENCY, AND TRANSPARENCY. THE PROJECT?S OUTCOMES ARE THE DOCUMENTATION OF MODEL PROCESSES AND USE CASES AND THE CREATION OF TOOLS AND OTHER RESOURCES THAT CAN BE USED BY EMERGING INSTITUTIONS AS A GUIDE TO STRENGTHEN THE SERVICES THEY OFFER TO HELP RESEARCHERS MORE EFFICIENTLY MANAGE THEIR AWARDS, ALLOWING THEM TIME TO FOCUS ON, AND PARTICIPATE IN, RESEARCH ACTIVITIES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

SEX CHROMOSOME EVOLUTION IN LIZARDS AND SNAKES -SEX CHROMOSOMES PLAY AN IMPORTANT ROLE IN THE EMBRYONIC DEVELOPMENT OF MANY ANIMAL SPECIES BY CONTROLLING AN INDIVIDUAL'S SEX. HOWEVER, THE SEX CHROMOSOMES OF MOST ANIMALS REMAIN UNIDENTIFIED LIMITING OUR UNDERSTANDING OF BROAD PATTERNS OF SEX CHROMOSOME EVOLUTION. THIS PROJECT WILL ADVANCE THE STUDY OF SEX CHROMOSOME EVOLUTION BY INVESTIGATING LIZARDS AND SNAKES. THESE REPTILES HAVE A VARIETY OF SEX-DETERMINING SYSTEMS WITH NUMEROUS EVOLUTIONARY TRANSITIONS AMONG THEM. EACH OF THESE INDEPENDENTLY DERIVED SYSTEMS CAN ACT AS A REPLICATE EVOLUTIONARY ?EXPERIMENT? TO TEST THE GENERAL PRINCIPLES AND PROCESSES THAT GOVERN SEX CHROMOSOME EVOLUTION. THIS RESEARCH WILL FILL GAPS IN OUR KNOWLEDGE BY IDENTIFYING SEX CHROMOSOMES IN THESE UNDER-STUDIED REPTILES AND THEN USE THESE DATA TO CHARACTERIZE SOME GENERAL PROPERTIES OF SEX CHROMOSOME EVOLUTION. THE RESEARCH WILL TRAIN A POSTDOCTORAL RESEARCHER AND STUDENTS, INCLUDING PHD STUDENTS AND UNDERGRADUATES, IN GENOMICS AND BIOINFORMATICS, SKILLS THAT ARE IN HIGH DEMAND FOR CAREERS IN AGRICULTURE, BIOTECHNOLOGY, AND HEALTH CARE. RESEARCHERS WILL DEVELOP GENETIC SEX TESTS FOR SEVERAL REPTILE SPECIES. SUCH TESTS ARE IMPORTANT FOR THE MANAGEMENT AND BREEDING OF ENDANGERED SPECIES AND SEXING EMBRYONIC MATERIAL IN DEVELOPMENTAL RESEARCH. RESEARCHERS WILL ENGAGE IN OUTREACH TO PET REPTILE HOBBYISTS AND THE GENERAL PUBLIC ABOUT GENETICS, EVOLUTION, AND SEX CHROMOSOMES VIA A MUSEUM EXHIBIT AND A BOOTH AT PET REPTILE TRADE SHOWS. COMPARATIVE STUDIES OF SEX CHROMOSOMES IN ANIMAL GROUPS WITH REPEATED TRANSITIONS AMONG SEX-DETERMINING MECHANISMS, LIKE THE LIZARDS AND SNAKES, CAN HELP ANSWER LONGSTANDING QUESTIONS ABOUT SEX CHROMOSOME EVOLUTION. THIS RESEARCH WILL INTEGRATE COMPARATIVE GENOMICS, TRANSCRIPTOMICS, AND PHYLOGENETICS TO ENHANCE THE UTILITY OF LIZARDS AND SNAKES AS A MODEL CLADE TO INVESTIGATE SEX CHROMOSOME EVOLUTION AND ADDRESS THE FOLLOWING QUESTIONS: 1) ARE SEX CHROMOSOMES AN EVOLUTIONARY TRAP? 2) ARE SOME CHROMOSOMES PARTICULARLY GOOD AT BEING SEX CHROMOSOMES? 3) IS SEX CHROMOSOME DOSAGE COMPENSATION MORE LIKELY TO EVOLVE IN XX/XY VS. ZZ/ZW TAXA? 4) WHAT IS THE RELATIVE ROLE OF REARRANGEMENTS VS. SEX-BIASED RECOMBINATION IN SUPPRESSING RECOMBINATION BETWEEN THE SEX CHROMOSOMES? UPON COMPLETION, THIS PROJECT WILL ENABLE SUBSEQUENT INVESTIGATIONS INTO THE MECHANISMS THAT DRIVE SEX CHROMOSOME EVOLUTION IN LIZARDS AND SNAKES AND ESTABLISH A FRAMEWORK FOR COMPARATIVE ANALYSES OF SEX CHROMOSOME EVOLUTION ACROSS THE TREE OF LIFE. DATA COLLECTED FOR THIS PROJECT WILL HAVE BROAD UTILITY TO OTHER SCIENTISTS, INCLUDING NEW, HIGH QUALITY GENOME ASSEMBLIES FOR MULTIPLE LIZARD AND SNAKE SPECIES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

TO COVER TUITION AND FEES FOR INSTATE AND OUT OF STATE STUDENTS ON A NROTC SCHOLARSHIP FOR THE FALL 2009 SEMESTER.

COLLABORATIVE RESEARCH: EDGE FGT: DEVELOPMENT OF FUNCTIONAL GENETIC TOOLS IN GECKOS - FUNCTIONAL GENOMIC TOOLS, SUCH AS CRISPR/CAS GENOME EDITING, ARE CRITICAL FOR INVESTIGATING THE BIOLOGY OF GENES AND HAVE TRANSFORMED OUR UNDERSTANDING OF GENOTYPE-TO-PHENOTYPE RELATIONSHIPS. HOWEVER, THE LIMITED NUMBER OF SPECIES WITH GENOME MODIFICATION METHODS PRESENTS A MAJOR BOTTLENECK IN IMPLEMENTING COMPREHENSIVE, COMPARATIVE STUDIES OF GENE FUNCTION. FOR INSTANCE, SQUAMATES (LIZARD AND SNAKES) INCLUDE MORE THAN 11,000 DESCRIBED SPECIES AND COMPRISE 40% OF ALL AMNIOTE SPECIES. YET BASIC GENE EDITING METHODS ARE ONLY AVAILABLE IN A SINGLE SPECIES, THE BROWN ANOLE LIZARD (ANOLIS SAGREI). HERE, WE PROPOSE TO: 1) ESTABLISH CRISPR/CAS GENE EDITING IN A SECOND LIZARD GROUP, THE GECKOS; 2) DEVELOP ADVANCED GENE EDITING METHODS FOR THE INTRODUCTION OF PRECISE SEQUENCE SUBSTITUTIONS, INSERTIONS, AND DELETIONS IN LIZARDS (IN BOTH ANOLIS AND GECKOS); AND 3) DISSEMINATE LIZARD GENE EDITING TECHNIQUES THROUGH TRAINING MATERIALS AND WORKSHOPS AND THE PRODUCTION OF GENOME-EDITED LIZARDS FOR RESEARCHERS. THE DEVELOPMENT OF GENE EDITING TOOLS IN GECKOS WILL INCREASE THE NUMBER OF SQUAMATE MODELS AVAILABLE FOR FUNCTIONAL GENOMIC WORK AND FACILITATE THE GENERALIZATION OF GENE FUNCTION STUDIES ACROSS SQUAMATES AND AMNIOTES. FURTHERMORE, GROWING THE FUNCTIONAL GENOMIC TOOLKIT IN LIZARDS TO INCLUDE MORE PRECISE GENE EDITING METHODS WILL EXPAND THE SCOPE OF QUESTIONS THAT CAN BE ADDRESSED IN THIS PHENOTYPICALLY DIVERSE GROUP.

CAMPUS BASED-FSEOG

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - ADDRESS: MARQUETTE UNIVERSITY SCHOOL OF DENTISTRY, 1801 WEST WISCONSIN AVENUE, MILWAUKEE, WISCONSIN PROJECT DIRECTOR NAME: WILLIAM K. LOBB, DEAN, MARQUETTE UNIVERSITY SCHOOL OF DENTISTRY CONTACT PHONE NUMBERS (VOICE, FAX): (414) 288-6546, FAX(414) 288-3586 EMAIL ADDRESS: WILLIAM.LOBB@MARQUETTE.EDU WEBSITE ADDRESS, IF APPLICABLE: HTTPS://WWW.MARQUETTE.EDU/DENTISTRY/ LIST ALL GRANT PROGRAM FUNDS REQUESTED IN THE APPLICATION, IF APPLICABLE: $1,020,853 WISCONSIN’S ONLY DENTAL SCHOOL SINCE 1894, THE MARQUETTE UNIVERSITY SCHOOL OF DENTISTRY (MUSOD) EDUCATES AND TRAINS FUTURE DENTISTS TO SERVE DIVERSE PATIENTS, INCLUDING AT-RISK GERIATRIC PATIENTS, UNDERSERVED ADULTS AND CHILDREN, AND SPECIAL NEEDS ADULT PATIENTS AND PROMOTING ORAL HEALTH STATEWIDE. BUILT IN 2002, MUSOD’S MAIN CAMPUS CLINIC, LOCATED IN MILWAUKEE, ANNUALLY SERVES NEARLY 17,000 PATIENTS FROM 53 OF WISCONSIN’S 72 COUNTIES. MUSOD PROVIDES ORAL HEALTH SERVICES THROUGH GENERAL DENTISTRY AND VARIOUS SPECIALTY CLINICS INCLUDING ADVANCED CLINICAL CARE (ACC), ENDODONTICS, PEDIATRIC , PERIODONTICS, PROSTHODONTICS, ORAL SURGERY, ORTHODONTICS, AND RADIOLOGY. NEARLY TWO-THIRDS OF THE PATIENTS ARE FROM MILWAUKEE COUNTY, MANY FROM HIGH-POVERTY NEIGHBORHOODS. MUSOD IS AMONG WISCONSIN’S LARGEST DENTAL MEDICAID (MA) PROVIDERS, ANNUALLY SERVING NEARLY 7,000 MA PATIENTS. MUSOD’S SPECIALTY CLINICS ARE NOTABLE FOR DELIVERING CARE CRITICAL TO ORAL HEALTH AND OVERALL HEALTH TO MANY MA AND UNDERSERVED PATIENTS. THIS REQUEST SUPPORTS DENTAL OPERATORY EQUIPMENT AS PART OF AN OVERALL MUSOD REVITALIZATION OF THE MAIN CLINIC’S FOUR ORIGINAL GENERAL PRACTICE DENTAL CLINICS, ALL SPECIALTY CLINICS, AND CENTRAL STERILIZATION. – MUSOD’S PROPOSED HRSA CONSTRUCTION GRANT REQUEST WILL UTILIZE ALL FUNDING TO PURCHASE 47 DENTAL OPERATORIES AND EQUIPMENT TO EDUCATE AND TRAIN PROSPECTIVE DENTISTS AND RESIDENTS TO PROVIDE CARE TO UNDERSERVED PATIENTS IN OUR ADVANCED CARE, PEDIATRIC, PROSTHODONTICS CLINICS AND PART OF THE GENERAL PRACTICE CLINICS. TYPICALLY, ONLY 10% OF DENTISTS CARE FOR PATIENTS WITH COGNITIVE/MEDICAL/PHYSICAL DISABILITIES AND THE SERVICES NEEDED ARE OFTEN NOT COVERED BY PRIVATE OR STATE INSURANCE PLANS. ACCORDING TO THE 2010 U.S. CENSUS, , 22% OF WISCONSIN’S CHILDREN HAVE A DISABILITY, MANY OF WHOM LACK REGULAR ORAL HEALTH CARE OPTIONS. THESE HRSA FUNDS TO SUPPORT UPGRADING DENTAL OPERATORIES WILL ALLOW MUSOD TO SIGNIFICANTLY IMPACT CARE FOR THIS POPULATION, WHICH HAS HIGHER RISK OF UNTREATED DENTAL CARIES AND PERIODONTAL DISEASE DUE TO PRESCRIBED MEDICATIONS, FEEDING REGIMENS, AND POOR DENTAL HYGIENE PRACTICES. ADDITIONALLY, THESE OPERATORIES ARE HEAVILY USED TO PROVIDE PATIENT CARE TO UNDERSERVED COMMUNITIES ACROSS THE WHOLE STATE OF WISCONSIN. MUSOD’S CONSTRUCTION GRANT REQUEST ALIGNS WITH HRSA’S 2019-2022 STRATEGIC PLAN GOALS 1-3: 1) IMPROVE ACCESS TO QUALITY HEALTH SERVICES; 2) FOSTER A HEALTH CARE WORKFORCE ABLE TO ADDRESS CURRENT AND EMERGING NEEDS; 3) ACHIEVE HEALTH EQUITY AND ENHANCE POPULATION HEALTH. MUSOD WILL DO THE FOLLOWING BECAUSE OF ACQUIRING THIS EQUIPMENT: - PROVIDE GREATER DIRECT ACCESS TO CARE FOR ADULTS WITH SPECIAL NEEDS TO IMPROVE THEIR ORAL HEALTH AND POSSIBLY PREVENT CERTAIN MEDICAL ISSUES AND TO REDUCE THE ORAL HEALTH DISPARITIES IN SPECIAL NEEDS PATIENTS. - INCREASE THE NUMBER OF PROSPECTIVE DENTISTS WHO ARE EDUCATED AND TRAINED TO PROVIDE CARE TO SPECIAL NEEDS DENTAL PATIENTS AND THE UNDERSERVED PATIENT POPULATIONS. - PROVIDE ONGOING PREVENTION AND INCREASE THE AMOUNT OF DENTAL CARE AVAILABLE FOR SPECIAL NEEDS PATIENTS TO MINIMIZE THE NEED FOR SEDATION AND GENERAL ANESTHESIA, THEREBY FURTHER REDUCING THE COSTS AND RISKS OF CARE. - ESTABLISH MUSOD AND EVENTUALLY OTHER DENTAL PROVIDERS AS A “DENTAL HOME” FOR SPECIAL NEEDS PATIENTS. - PROVIDE DIRECT ACCESS TO CARE FOR UNDERSERVED CHILDREN AND ADULTS IN MUSOD’S PEDIATRIC CLINIC AND GENERAL DENTISTRY CLINICS.

TO COVER TUITION AND FEES FOR THE IN STATE AND OUT OF STATE STUDENTS ON A NROTC SCHOLARSHIP FOR THE 2009 SPRING SEMESTER UNDER MARQUETTE UNIVERSITY'S NROTC PROGRAM.

SYNTHETIC, SPECTROSCOPIC, AND COMPUTATIONAL INVESTIGATIONS OF THIOL OXIDATION BY NONHEME IRON ENZYMES

SPATIAL AND TEMPORAL MECHANISMS UNDERLYING AGGREGATE FORMATION

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM- AMERICAN RESCUE PLAN

TO COVER TUITION AND FEES FOR IN-STATE AND OUT-OF-STATE STUDENTS ON A NROTC SCHOLARSHIP FOR THE 2008-2009 FALL SEMESTER.

LIANAS AS A KEYSTONE GUILD IN TROPICAL FORESTS: AN EXPERIMENTAL TEST

TO COVER TUITION AND FEES FOR IN-STATE AND OUT-OF-STATE STUDENTS ON A NROTC SCHOLARSHIP FOR THE 2007 FALL SEMESTER.

FUNCTIONAL ANALYSIS OF MICRORNAS IN C. ELEGANS SPERMATOGENESIS

PREPARING MATHEMATICS AND SCIENCE TEACHERS FOR COMPUTER SCIENCE TEACHER CERTIFICATION AND EXPERTISE -THE PROJECT AIMS TO SERVE THE NATIONAL NEED FOR HIGH-QUALITY MATHEMATICS AND SCIENCE TEACHERS WHO ALSO HAVE KNOWLEDGE AND CERTIFICATION TO TEACH COMPUTER SCIENCE, ADDRESSING SERIOUS SHORTAGES IN THE UNITED STATES STEM TEACHING FORCE. THE UNIQUE CONTRIBUTION OF THIS GRADUATE PROGRAM WILL BE TO COMBINE A FIELD-EMBEDDED INTRODUCTION TO AMBITIOUS STEM INSTRUCTION WITH EXTENSIVE PEDAGOGICAL CONTENT KNOWLEDGE IN COMPUTER SCIENCE EDUCATION, PRODUCING HIGHLY QUALIFIED MATHEMATICS AND SCIENCE TEACHERS WHO CAN ALSO TEACH COMPUTER SCIENCE COURSES IN HIGH-NEED SCHOOLS. GRADUATES OF THE PROGRAM WILL COMPLETE REQUIREMENTS FOR MIDDLE AND SECONDARY LEVEL TEACHER CERTIFICATION IN MATHEMATICS OR SCIENCE AND REQUIREMENTS FOR COMPUTER SCIENCE EDUCATION CERTIFICATION. GRADUATES WILL THEN SERVE AS TEACHERS IN HIGH-NEED SCHOOLS, EQUIPPED WITH PEDAGOGICAL SKILLS AND QUALIFICATIONS IN COMPUTER SCIENCE AND MATHEMATICS OR SCIENCE, AND PREPARED WITH A HIGHLY DESIRABLE COMBINATION OF SKILLS TO SERVE IN HIGH-NEED ENVIRONMENTS. THIS PROJECT AT MARQUETTE UNIVERSITY INCLUDES PARTNERSHIPS WITH MILWAUKEE PUBLIC SCHOOLS, MILWAUKEE AREA CHARTER SCHOOLS, THE SHOREWOOD SCHOOL DISTRICT, AND SCHOOLS IN THE ARCHDIOCESE OF MILWAUKEE. PROJECT GOALS INCLUDE RECRUITING 24 HIGHLY QUALIFIED STEM PROFESSIONALS AND PREPARING THEM TO ENTER HIGH-NEED SCHOOL ENVIRONMENTS WITH A MASTER OF EDUCATION AND TEACHER CERTIFICATIONS. THE PROJECT WILL DEVELOP A MULTIMODAL (IN PERSON AND ONLINE) PATHWAY THAT WILL LEAD TO COMPUTER SCIENCE TEACHER CERTIFICATION ALONGSIDE MATHEMATICS OR SCIENCE TEACHER CERTIFICATION. THE PROJECT IS THEORETICALLY GROUNDED IN PRACTICE-BASED TEACHER PREPARATION, AMBITIOUS INSTRUCTION, AND PEDAGOGICAL CONTENT KNOWLEDGE FOR COMPUTER SCIENCE INSTRUCTION. IN KEEPING WITH CURRENT REFORMS IN K-12 STEM EDUCATION AND TEACHER EDUCATION, AMBITIOUS INSTRUCTION SUPPORTS ALL STUDENTS, REGARDLESS OF RACE, SOCIOECONOMIC STATUS, ETHNICITY, GENDER, AND IDENTITY, IN RIGOROUS AND CONCEPTUAL LEARNING OF STEM CONTENT. ADDITIONALLY, THE PROJECT WILL SUPPORT GRADUATES IN THEIR EARLY PROFESSIONAL PRACTICE. RESEARCH QUESTIONS WILL ADDRESS EFFECTIVE PEDAGOGIES FOR DEVELOPING AMBITIOUS TEACHING PRACTICES IN MATHEMATICS, SCIENCE, AND COMPUTER SCIENCE, PARTICULARLY FOCUSED ON PEDAGOGIES OF ENACTMENT AND SCHOLAR DEVELOPMENT OF AMBITIOUS TEACHING ACROSS STEM FIELDS THROUGH QUALITATIVE AND OBSERVATIONAL RESEARCH METHODS. THE PROJECT WILL CONTRIBUTE TO THE EMPIRICAL KNOWLEDGE BASE BY ADVANCING INTERSECTIONAL RESEARCH ON COMPUTER SCIENCE EDUCATION, AMBITIOUS STEM INSTRUCTION, AND PRACTICE-BASED TEACHER PREPARATION. THE MAIN IMPACT OF THE PROJECT IS TO IMPROVE THE QUALITY OF STEM INSTRUCTION AND EXPAND COMPUTER SCIENCE PROGRAMS IN AREA SECONDARY HIGH-NEED SCHOOLS. THIS TRACK 1: SCHOLARSHIPS AND STIPENDS PROJECT IS SUPPORTED THROUGH THE ROBERT NOYCE TEACHER SCHOLARSHIP PROGRAM (NOYCE). THE NOYCE PROGRAM SUPPORTS TALENTED STEM UNDERGRADUATE MAJORS AND PROFESSIONALS TO BECOME EFFECTIVE K-12 STEM TEACHERS AND EXPERIENCED, EXEMPLARY K-12 TEACHERS TO BECOME STEM MASTER TEACHERS IN HIGH-NEED SCHOOL DISTRICTS. IT ALSO SUPPORTS RESEARCH ON THE RETENTION AND EFFECTIVENESS OF K-12 STEM TEACHERS IN HIGH-NEED SCHOOL DISTRICTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

TO COVER TUITION AND FEES FOR IN-STATE AND OUT-OF-STATE STUDENTS ON THE NROTC SCHOLARSHIP FOR THE 2008 SPRING SEMESTER.

INCREASING THE SUPPLY AND IMPROVING THE SKILLS OF QUALIFIED REHABILITATION COUNSELORS WITH MENTAL ILLNESS SPECIALTIES IN MILWAUKEE AND SOUTHEASTERN WISCONSIN